Product image of Lipanthyl Supra (Fenofibrate Micronised) supplied by GNH India

Lipanthyl Supra

Active Ingredient:
Fenofibrate Micronised
Origin:
EU

Lipanthyl Supra (Fenofibrate Micronised)

Fenofibrate, the active ingredient in Lipanthyl Supra, is a fibrate presented as a micronised oral tablet for oral use. It lowers elevated triglycerides and cholesterol in patients with dyslipidaemia, helping to manage hypertriglyceridaemia, mixed dyslipidaemia and primary hypercholesterolaemia as part of a comprehensive lipid‑lowering regimen.

GNH India supplies Lipanthyl Supra as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for global healthcare providers, including regulatory documentation and temperature‑controlled logistics where required.

Manufacturer / TM Owner

Viatris Healthcare Sp. Z O.O.

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Indications & Clinical Uses

  • Lipanthyl Supra (fenofibrate) is used to treat lipid disorders by reducing triglyceride‑rich lipoproteins.
  • Hypertriglyceridemia: reduces very‑low‑density lipoprotein (VLDL) and triglyceride levels.
  • Mixed dyslipidemia: lowers triglycerides while modestly increasing HDL‑cholesterol.
  • Primary hypercholesterolemia (adjunct): improves overall lipid profile when combined with statin therapy.

How It Works

  • Fenofibrate activates peroxisome proliferator‑activated receptor‑alpha (PPARα), a nuclear transcription factor that up‑regulates genes involved in fatty‑acid β‑oxidation, lipoprotein lipase activity and apolipoprotein synthesis. This enhances catabolism of triglyceride‑rich particles, reduces hepatic VLDL production, and modestly raises HDL‑cholesterol, resulting in lowered plasma triglycerides and improved lipid profile. The overall effect contributes to decreased atherogenic risk in patients with dyslipidaemia and supports cardiovascular health.

Side Effects

Fenofibrate may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal discomfort: nausea, abdominal pain or dyspepsia.
  • Headache: mild to moderate intensity.
  • Elevated liver enzymes: transient increase in ALT/AST.
  • Muscle pain: mild myalgia without weakness.

Serious or Rare Side Effects

  • Rhabdomyolysis: severe muscle breakdown with risk of renal failure.
  • Severe liver injury: marked hepatitis or hepatic failure.
  • Hypersensitivity reactions: rash, pruritus or angioedema.

Precautions & Warnings

  • Before prescribing Lipanthyl Supra, clinicians should consider several precautionary measures to ensure safe use.
  • Renal function: assess creatinine clearance in patients with renal impairment.
  • Liver disease: avoid or monitor in active hepatic disease.
  • Gallbladder disease: use with caution in patients with gallstones.
  • Drug interactions: review concomitant medications that affect CYP enzymes.
  • Pregnancy and lactation: evaluate risk‑benefit; use only if clearly needed.
  • Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture.

Avoid Interactions

Fenofibrate can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Gemfibrozil: combined use markedly increases risk of myopathy and rhabdomyolysis.
  • Cyclosporine: may raise fenofibrate plasma levels, enhancing toxicity.
  • Warfarin: can potentiate anticoagulant effect, increasing INR.

Moderate Interactions (Monitor Closely)

  • Statins (especially high‑dose simvastatin): increased risk of muscle toxicity.
  • Antidiabetic agents: fenofibrate may affect glycemic control.
  • Thiazide diuretics: may increase serum uric acid, precipitating gout.

Frequently Asked Questions

Lipanthyl Supra contains fenofibrate, a fibrate class medication that is prescribed to lower elevated triglyceride and cholesterol levels. It is indicated for the treatment of hypertriglyceridemia, mixed dyslipidemia, and as an adjunct therapy in primary hypercholesterolemia when additional lipid control is required.

Fenofibrate activates the nuclear receptor PPARα, which regulates genes involved in fatty‑acid oxidation and lipoprotein metabolism. By enhancing the breakdown of triglyceride‑rich particles and reducing hepatic VLDL production, it lowers plasma triglycerides and modestly raises HDL‑cholesterol, improving the overall lipid profile.

The appropriate dose of Lipanthyl Supra is individualized by the prescribing healthcare professional based on the patient’s specific lipid profile, renal and hepatic function, and any concomitant medications. The prescriber will select the dose that best balances efficacy with safety for each patient.

The safety of fenofibrate during pregnancy or lactation has not been definitively established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider after careful assessment.

To request Lipanthyl Supra, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any temperature‑controlled logistics) and the necessary import documentation.

Lipanthyl Supra belongs to the fibrate class, which primarily lowers triglycerides, whereas statins are the main alternative class that primarily reduce LDL‑cholesterol. Fibrates are often added to statin therapy when triglycerides remain high. Compared with gemfibrozil, fenofibrate generally has a more favorable safety profile and fewer drug‑interaction concerns.

Lipanthyl Supra should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Lipanthyl Supra is taken orally, usually once daily with a meal to improve absorption. The tablet should be swallowed whole with water and not crushed or chewed unless otherwise directed by a healthcare professional.

The most serious adverse events associated with fenofibrate include rhabdomyolysis (severe muscle breakdown that can lead to kidney failure) and significant liver injury such as hepatitis or hepatic failure. Patients should promptly report unexplained muscle pain, weakness, dark urine, or signs of liver dysfunction such as jaundice.

Lipanthyl Supra is contraindicated in patients with known hypersensitivity to fenofibrate or any component of the formulation, severe liver disease, active gallbladder disease, and in individuals with a history of rhabdomyolysis. Caution is also advised for patients with renal impairment, and it should be avoided in combination with certain interacting drugs such as gemfibrozil.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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