Product image of Lipertance (Amlodipine Besilate, Perindopril Arginine, Atorvastatin Calcium Trihydrate) supplied by GNH India

Lipertance

Active Ingredient:
Amlodipine Besilate, Perindopril Arginine, Atorvastatin Calcium Trihydrate
Origin:
EU

Lipertance (Amlodipine Besilate, Perindopril Arginine, Atorvastatin Calcium Trihydrate)

Amlodipine besilate / Perindopril arginine / Atorvastatin calcium, the active ingredient in Lipertance, is a combination antihypertensive and lipid‑lowering drug presented as a combination tablet for oral use. It treats hypertension and hyperlipidemia in adult patients.

GNH India supplies Lipertance as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Les Laboratoires Servier (Suresnes)

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Indications & Clinical Uses

Lipertance is indicated for conditions involving elevated blood pressure and abnormal lipid levels.

  • Hypertension: helps lower systolic and diastolic blood pressure.
  • Hyperlipidemia: reduces LDL‑cholesterol and total cholesterol.
  • Cardiovascular risk reduction: contributes to lowering overall risk of cardiovascular events in patients with both hypertension and dyslipidemia.

How It Works

  • Lipertance combines three agents that act on complementary pathways. Amlodipine besilate blocks L‑type calcium channels in vascular smooth muscle, producing vasodilation and reduced peripheral resistance. Perindopril arginine inhibits angiotensin‑converting enzyme, decreasing formation of angiotensin II and lowering blood pressure. Atorvastatin calcium inhibits HMG‑CoA reductase, reducing hepatic cholesterol synthesis and increasing LDL‑receptor expression, thereby lowering plasma LDL‑cholesterol.

Side Effects

Adverse reactions reported with Lipertance reflect the known safety profiles of its three components.

Common Side Effects

  • Headache: mild to moderate headache.
  • Dizziness: transient dizziness, especially after first dose.
  • Peripheral edema: swelling of ankles or feet.
  • Gastrointestinal discomfort: nausea, abdominal pain or dyspepsia.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue or airway.
  • Severe liver injury: marked elevation of transaminases or jaundice.
  • Myopathy or rhabdomyolysis: muscle pain with elevated CK, especially with atorvastatin.
  • Hyperkalemia: elevated potassium levels due to ACE inhibition.

Precautions & Warnings

Before prescribing Lipertance, clinicians should consider the following precautions.

  • Renal impairment: adjust dose and monitor renal function in patients with reduced kidney function.
  • Hepatic disease: avoid or use with caution in patients with active liver disease; monitor liver enzymes.
  • Pregnancy: contraindicated or not recommended during pregnancy; discuss risks with women of childbearing potential.
  • Concomitant potassium‑sparing diuretics: monitor serum potassium to avoid hyperkalemia.
  • Drug hypersensitivity: discontinue if signs of allergic reaction such as rash or angioedema appear.
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture and light.

Avoid Interactions

Lipertance may interact with several medicines; awareness of major and moderate interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

  • ACE inhibitor with potassium‑rich supplements or spironolactone: risk of severe hyperkalemia.
  • Strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole): increase atorvastatin exposure, raising risk of myopathy.
  • Simultaneous use of other calcium‑channel blockers: additive hypotensive effect.
  • Nitrates: may cause excessive vasodilation and hypotension.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may reduce antihypertensive efficacy and affect renal function.
  • Diuretics: may enhance hypotensive effect; monitor blood pressure and electrolytes.
  • Antacids containing aluminum or magnesium: may reduce absorption of amlodipine; separate dosing by at least 2 hours.

Frequently Asked Questions

Lipertance is a prescription combination tablet that treats two common cardiovascular conditions: hypertension (high blood pressure) and hyperlipidemia (elevated cholesterol). By addressing both blood pressure and lipid levels, it helps reduce the overall risk of heart attack, stroke and other vascular events in adult patients.

Amlodipine blocks L‑type calcium channels, causing blood vessels to relax and lowering peripheral resistance. Perindopril inhibits the angiotensin‑converting enzyme, reducing angiotensin II formation and further decreasing blood pressure. Atorvastatin blocks HMG‑CoA reductase, the key enzyme in cholesterol synthesis, leading to lower LDL‑cholesterol and total cholesterol levels.

The appropriate dose of Lipertance is determined by the prescribing healthcare professional based on the patient’s clinical condition, response to therapy and any relevant laboratory values. Dosage may be adjusted over time, and patients should follow the exact regimen provided by their prescriber.

Lipertance is generally not recommended for use during pregnancy because the ACE‑inhibitor component (perindopril) can affect fetal development. Breastfeeding mothers should consult their physician, as the drug may be excreted in milk and could pose risks to the infant. Alternative therapies are usually considered.

To order Lipertance, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets. After the request, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details and any necessary import documentation.

Lipertance combines a calcium‑channel blocker, an ACE inhibitor and a statin in a single tablet, offering a convenient triple‑therapy option. Compared with separate prescriptions, it reduces pill burden and may improve adherence. Some alternatives use a beta‑blocker or diuretic instead of amlodipine, but the overall efficacy in controlling blood pressure and cholesterol is comparable when doses are equivalent.

Store Lipertance at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack or container, protect them from moisture, heat and direct sunlight. Do not store in the bathroom or near a kitchen sink, and keep out of reach of children.

Lipertance is taken orally, usually once daily, with or without food. Swallow the tablet whole with a glass of water. If a dose is missed, take it as soon as remembered unless it is near the time of the next scheduled dose; in that case, skip the missed dose and continue the regular schedule.

The most serious adverse events include angioedema (swelling of the face, lips, tongue or airway), severe liver injury (jaundice or marked enzyme elevation), myopathy or rhabdomyolysis (muscle pain with high creatine kinase), and hyperkalemia (elevated potassium). Patients should seek immediate medical attention if they experience any of these symptoms.

Lipertance should be avoided in patients with known hypersensitivity to any of its components, severe hepatic impairment, or in women who are pregnant. Caution is also advised for individuals with significant renal dysfunction, uncontrolled electrolyte disorders, or those taking contraindicated medications such as strong CYP3A4 inhibitors without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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