Product image of Lipiclair (Fenofibrate) supplied by GNH India

Lipiclair

Active Ingredient:
Fenofibrate
Origin:
EU

Lipiclair (Fenofibrate)

Fenofibrate, the active ingredient in Lipiclair, is a fibrate presented as an oral tablet for oral use. It treats hypertriglyceridemia, mixed dyslipidemia and primary hypercholesterolemia as adjunct therapy in adults.

GNH India supplies Lipiclair as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ethypharm

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Indications & Clinical Uses

  • Lipiclair (fenofibrate) acts on lipid metabolism disorders to improve blood lipid profiles.
  • Hypertriglyceridemia: lowers elevated triglyceride levels.
  • Mixed dyslipidemia: reduces triglycerides and LDL‑cholesterol while increasing HDL‑cholesterol.
  • Primary hypercholesterolemia (adjunct therapy): adds further LDL‑cholesterol reduction when combined with statins.

How It Works

  • Fenofibrate activates peroxisome proliferator‑activated receptor alpha (PPARα), a nuclear transcription factor that enhances lipolysis, increases oxidation of fatty acids, reduces hepatic synthesis of very‑low‑density lipoprotein (VLDL) particles, and promotes synthesis of high‑density lipoprotein (HDL). These actions collectively lower plasma triglycerides and improve overall lipid profiles.

Side Effects

Common Side Effects

  • Gastrointestinal discomfort such as nausea, dyspepsia or abdominal pain.
  • Headache.
  • Muscle aches or mild myalgia.
  • Elevated liver enzymes.
  • Elevated serum creatinine.

Serious or Rare Side Effects

  • Rhabdomyolysis or severe myopathy, especially with statins.
  • Significant hepatic injury or hepatitis.
  • Severe hypersensitivity reactions, including skin rash or angioedema.
  • Acute pancreatitis.

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety aspects.
  • Liver function monitoring: assess baseline hepatic enzymes and repeat periodically.
  • Renal function monitoring: evaluate creatinine clearance, especially in patients with renal impairment.
  • Gallbladder disease assessment: avoid use in patients with active gallstones or biliary obstruction.
  • Muscle symptom vigilance: educate patients to report unexplained muscle pain or weakness.
  • Drug interaction review: check concomitant medications that may increase risk of myopathy.
  • Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Fenofibrate may interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • High‑dose statins (e.g., rosuvastatin) – increased risk of rhabdomyolysis.
  • Gemfibrozil – synergistic myopathy risk.
  • Cyclosporine – elevated fenofibrate plasma levels.
  • Warfarin – potential enhancement of anticoagulant effect.

Moderate Interactions (Monitor Closely)

  • Bile‑acid sequestrants – may reduce fenofibrate absorption.
  • Oral contraceptives – possible alteration of lipid parameters.
  • Antihypertensive agents – monitor blood pressure changes.
  • Other lipid‑lowering agents – assess cumulative lipid effects.

Frequently Asked Questions

Lipiclair contains fenofibrate, a fibrate class medication used to lower elevated triglyceride levels, improve mixed dyslipidemia, and serve as an adjunct to statin therapy for primary hypercholesterolemia. It is prescribed for adults with these lipid disorders to reduce cardiovascular risk.

Fenofibrate activates the nuclear receptor PPARα, which regulates genes involved in fatty‑acid oxidation and lipoprotein metabolism. Activation leads to increased breakdown of triglyceride‑rich particles, reduced VLDL synthesis, and enhanced HDL production, thereby improving the overall lipid profile.

The specific dose of Lipiclair is determined by the prescribing clinician based on the patient’s lipid levels, renal function, and overall health status. Physicians follow established dosing guidelines for fenofibrate but individual regimens may vary.

Safety data for fenofibrate in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Lipiclair, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative to fenofibrate is the statin class, which primarily lowers LDL‑cholesterol. Fenofibrate is more effective at reducing triglycerides and raising HDL‑cholesterol, while statins are stronger LDL‑reducers. In some patients, a combination of both classes is used for comprehensive lipid management.

Lipiclair should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children.

Lipiclair is taken orally, usually once daily with a meal to enhance absorption. Patients should swallow the tablet whole with water and follow the dosing schedule prescribed by their healthcare provider.

The most serious risks include rhabdomyolysis (severe muscle breakdown), significant liver injury, and rare hypersensitivity reactions such as severe skin rash or angioedema. Patients should promptly report unexplained muscle pain, dark urine, jaundice, or any signs of an allergic reaction.

Lipiclair is contraindicated in patients with severe liver disease, active gallbladder disease, or known hypersensitivity to fenofibrate or any excipients. Caution is also advised for individuals with renal impairment or those taking medications that markedly increase the risk of myopathy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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