Product image of Lipidem (Omega-3-Acid Triglycerides, Soya-Bean Oil Refined, Triglycerides, Medium Chain) supplied by GNH India

Lipidem

Active Ingredient:
Omega-3-Acid Triglycerides, Soya-Bean Oil Refined, Triglycerides, Medium Chain
Origin:
EU

Lipidem (Omega-3-Acid Triglycerides, Soya-Bean Oil Refined, Triglycerides, Medium Chain)

Omega-3-Acid Triglycerides, the active ingredient in Lipidem, is an Omega-3 fatty acid supplement presented as an intravenous lipid emulsion for intravenous use. It provides essential fatty acids and calories for patients requiring parenteral nutrition, helping prevent deficiency and support energy needs.

GNH India supplies Lipidem as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology units and pharmacy chains worldwide, ensuring regulatory‑approved quality and reliable cold‑chain logistics for parenteral nutrition products. The company adheres to EU GMP standards and provides comprehensive technical support to clinical teams.

Manufacturer / TM Owner

B.Braun Melsungen Ag

1
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Indications & Clinical Uses

Lipidem, an intravenous omega‑3 fatty acid lipid emulsion, is used in parenteral nutrition to address essential fatty acid deficiency and provide caloric support.

  • Parenteral nutrition: supplies calories and essential fatty acids for patients unable to receive enteral feeding.
  • Essential fatty acid deficiency prevention: restores omega‑3 and omega‑6 fatty acid levels in patients on long‑term lipid‑free nutrition.
  • Caloric supplementation: delivers high‑energy triglycerides to support metabolic demands in critically ill or postoperative patients.

How It Works

  • The emulsion delivers medium‑chain triglycerides and refined soybean oil rich in omega‑3 fatty acids directly into the bloodstream. These lipids are hydrolyzed by lipoprotein lipase, releasing free fatty acids that serve as an immediate energy source and are incorporated into cell membrane phospholipids, thereby maintaining membrane integrity and providing essential polyunsaturated fatty acids required for physiological functions. The process also supports synthesis of eicosanoids and other signaling molecules.

Side Effects

Lipidem may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Hypertriglyceridemia: elevated blood triglyceride levels.
  • Fever or chills: transient temperature rise after infusion.
  • Phlebitis: irritation at the infusion site.
  • Lipemia: milky appearance of plasma.

Serious or Rare Side Effects

  • Fat overload syndrome: hepatic dysfunction due to excessive lipid load.
  • Anaphylactoid reaction: severe hypersensitivity with respiratory distress.
  • Coagulopathy: impaired clotting due to high omega‑3 content.

Precautions & Warnings

When using Lipidem, clinicians should observe specific precautions to ensure patient safety and product integrity.

  • Patient assessment: evaluate baseline triglyceride levels and liver function before initiation.
  • Monitoring: check serum triglycerides and liver enzymes regularly during therapy.
  • Compatibility: avoid mixing with incompatible IV solutions such as calcium‑containing admixtures.
  • Infusion rate: administer at recommended rate to reduce risk of hypertriglyceridemia and fat overload.
  • Special populations: use caution in neonates, patients with pancreatitis, or severe hyperlipidaemia.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lipidem can interact with certain medications and nutritional components, requiring attention to dosing and monitoring.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk due to omega‑3 antiplatelet effect.
  • Propofol infusion: additive lipid load may precipitate hypertriglyceridemia.
  • High‑dose vitamin E supplements: synergistic anticoagulant effect increasing hemorrhage risk.

Moderate Interactions (Monitor Closely)

  • Other parenteral lipid emulsions: cumulative lipid intake may exceed safe limits.
  • Immunosuppressants (e.g., cyclosporine): potential alteration of lipid metabolism.
  • Diuretics (e.g., furosemide): may affect electrolyte balance when combined with high‑fat infusions.

Frequently Asked Questions

Lipidem is an intravenous lipid emulsion that provides essential fatty acids and a concentrated source of calories. It is employed in parenteral nutrition regimens for patients who cannot receive enteral feeding, helps prevent essential fatty acid deficiency, and supports the high energy demands of critically ill or postoperative individuals.

Omega-3-Acid Triglycerides are hydrolyzed by lipoprotein lipase after infusion, releasing free fatty acids that serve as an immediate energy substrate. The fatty acids are also incorporated into cell‑membrane phospholipids, supplying polyunsaturated fatty acids needed for membrane integrity, eicosanoid synthesis, and other cellular functions.

The dose of Lipidem is individualized by the prescribing clinician based on the patient’s caloric requirements, body weight, underlying condition, and laboratory parameters such as triglyceride and liver‑function tests. No fixed regimen is provided; the healthcare professional calculates the appropriate volume and infusion rate for each case.

Safety data for Lipidem during pregnancy and lactation are limited. Because it contains high levels of omega‑3 fatty acids, it may be used when the potential benefit to the mother outweighs any theoretical risk to the fetus or infant. The decision should be made by the treating physician in consultation with obstetric specialists.

To place an order, submit an enquiry on the Lipidem product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling where required) and any necessary import documentation.

Lipidem is distinguished by its blend of refined soybean oil and medium‑chain triglycerides rich in omega‑3 fatty acids, offering a balanced omega‑6 to omega‑3 ratio. Compared with traditional soybean‑only emulsions, it may provide a lower risk of inflammation and a more favorable lipid profile, while delivering comparable caloric density for parenteral nutrition.

Lipidem must be stored refrigerated between 2 °C and 8 °C. It should be kept in its original container, protected from light, and must not be frozen or shaken vigorously. Before use, allow the emulsion to reach room temperature if required by the administration protocol, and inspect for any signs of separation or discoloration.

Lipidem is administered intravenously as a sterile lipid emulsion. It is typically infused through a dedicated lumen or a compatible IV line using an infusion pump to control the rate. The infusion rate is set according to the prescribed caloric goal and patient tolerance, and the line is monitored for signs of phlebitis or infiltration.

Serious adverse events include fat overload syndrome, which can cause hepatic dysfunction, and severe hypersensitivity reactions such as anaphylactoid responses. Additionally, excessive lipid administration may lead to hypertriglyceridemia and coagulopathy. Prompt recognition of these signs and immediate medical intervention are essential.

Lipidem is contraindicated in patients with known hypersensitivity to any component of the emulsion, those with severe hyperlipidaemia, uncontrolled pancreatitis, or a documented fat overload syndrome. Caution is also advised for neonates, patients with severe liver disease, or individuals receiving concurrent high‑dose lipid‑containing therapies.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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