Product image of Lipidem (Omega-3-Acid Triglycerides, Soya-Bean Oil Refined, Triglycerides, Medium Chain) supplied by GNH India

Lipidem

Active Ingredient:
Omega-3-Acid Triglycerides, Soya-Bean Oil Refined, Triglycerides, Medium Chain
Origin:
EU

Lipidem (Omega-3-Acid Triglycerides, Soya-Bean Oil Refined, Triglycerides, Medium Chain)

Omega-3-acid triglycerides, the active ingredient in Lipidem, is a parenteral lipid emulsion presented as an intravenous lipid emulsion for intravenous use. It provides essential fatty acids and calories for patients receiving parenteral nutrition, helping prevent essential fatty acid deficiency and supporting cellular membrane integrity.

GNH India supplies Lipidem as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

B.Braun Melsungen Ag

1
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Indications & Clinical Uses

Lipidem is used in parenteral nutrition to supply essential fatty acids and calories.

  • Total parenteral nutrition (TPN): supplies calories and essential fatty acids to patients unable to receive enteral feeding.
  • Essential fatty acid deficiency prevention: provides omega‑3 fatty acids to maintain cell membrane integrity.
  • Critical or surgical patients receiving TPN: supports energy needs and reduces risk of deficiency during intensive care.

How It Works

  • Lipidem delivers a triglyceride‑rich lipid emulsion that is hydrolyzed by plasma lipases into free fatty acids and glycerol. These components are taken up by tissues, incorporated into phospholipids for cell membranes, and oxidized for energy, thereby supplying essential fatty acids and caloric support during total parenteral nutrition.

Side Effects

Lipidem may cause a range of infusion‑related reactions.

Common Side Effects

  • Hypertriglyceridemia: elevated blood triglyceride levels.
  • Fever or chills during infusion.
  • Infusion site erythema or pain.
  • Elevated liver enzymes (ALT/AST).
  • Electrolyte disturbances (e.g., hypophosphatemia).

Serious or Rare Side Effects

  • Fat overload syndrome: severe hyperlipidemia with organ dysfunction.
  • Pulmonary embolism or respiratory distress.
  • Anaphylactic or severe allergic reactions.
  • Infection risk from contaminated infusion.
  • Thrombocytopenia or coagulation abnormalities.

Precautions & Warnings

When using Lipidem, clinicians should observe several safety measures.

  • Triglyceride monitoring: check serum triglyceride levels regularly.
  • Liver function: assess hepatic enzymes before and during therapy.
  • Allergy assessment: verify no known hypersensitivity to soy, egg, or fish oils.
  • Hyperlipidemia caution: use carefully in patients with pre‑existing lipid disorders.
  • Concomitant lipid sources: avoid combining with other lipid emulsions to prevent fat overload.
  • Store at 2‑8 °C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lipidem can interact with other medications affecting lipid metabolism or coagulation.

Major Interactions (Avoid)

  • Concurrent lipid emulsions (e.g., propofol): risk of severe hypertriglyceridemia.
  • High‑dose heparin therapy: may exacerbate triglyceride elevation.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (warfarin, DOACs): lipid infusion may alter INR or bleeding risk.
  • Corticosteroids: can increase serum triglyceride concentrations.
  • Certain antibiotics (e.g., ceftriaxone): may precipitate when mixed with lipid emulsions.
  • Immunosuppressants: monitor for altered drug levels due to changes in plasma protein binding.

Frequently Asked Questions

Lipidem is an intravenous lipid emulsion used in total parenteral nutrition to provide essential fatty acids and calories to patients who cannot receive enteral feeding, helping prevent essential fatty acid deficiency and supporting metabolic needs during critical illness or surgery.

The omega‑3‑acid triglycerides in Lipidem are hydrolyzed by plasma lipases into free fatty acids and glycerol. These are incorporated into cell membranes and oxidized for energy, delivering essential fatty acids and caloric support required for patients on parenteral nutrition.

The dose of Lipidem is individualized by the prescribing clinician based on the patient’s caloric requirements, lipid tolerance, and clinical condition. Dosage calculations consider factors such as body weight, metabolic needs, and laboratory monitoring.

Safety data for Lipidem in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To order Lipidem, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Lipidem contains omega‑3‑acid triglycerides derived from refined soybean oil, offering a balanced profile of essential fatty acids. Compared with emulsions based solely on soybean or safflower oil, Lipidem provides higher omega‑3 content, which may better support anti‑inflammatory effects and membrane fluidity, though clinical choice depends on patient-specific factors and institutional protocols.

Lipidem must be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the container. Before administration, allow the product to reach room temperature if required by the infusion protocol, and inspect for any signs of contamination or phase separation.

Lipidem is administered intravenously as an infusion, typically added to a total parenteral nutrition bag or given as a separate lipid infusion. The infusion rate is set by the clinician based on the prescribed lipid dose and the patient’s tolerance, with continuous monitoring for adverse reactions.

The most serious risks include fat overload syndrome, severe hypertriglyceridemia, pulmonary embolism, and anaphylactic reactions. Patients should be closely monitored for signs of respiratory distress, rapid rise in triglyceride levels, and any allergic manifestations during and after infusion.

Lipidem should be avoided in patients with known hypersensitivity to soybean oil, egg phospholipids, or any component of the emulsion. It is also contraindicated in individuals with severe hyperlipidemia, uncontrolled sepsis, or those receiving multiple lipid sources that could cause fat overload.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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