Product image of Lipidem (Omega-3-Acid Triglycerides, Soya-Bean Oil Refined, Triglycerides, Medium Chain) supplied by GNH India

Lipidem

Active Ingredient:
Omega-3-Acid Triglycerides, Soya-Bean Oil Refined, Triglycerides, Medium Chain
Origin:
EU

Lipidem (Omega-3-Acid Triglycerides, Soya-Bean Oil Refined, Triglycerides, Medium Chain)

Omega-3-acid triglycerides, the active ingredient in Lipidem, is a parenteral lipid emulsion presented as an intravenous emulsion for intravenous use. It provides essential fatty acids and calories for patients requiring parenteral nutrition, helping prevent essential fatty acid deficiency.

GNH India supplies Lipidem as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

Lipidem is employed in clinical nutrition to address lipid needs in patients receiving parenteral feeding.

  • Parenteral nutrition: supplies calories and essential fatty acids to patients unable to receive enteral feeding.
  • Essential fatty acid deficiency prevention: delivers omega‑3 fatty acids to maintain membrane integrity in patients on long‑term lipid‑free parenteral solutions.
  • Critical care support: supports energy metabolism and cell‑membrane synthesis in critically ill patients receiving total parenteral nutrition.

How It Works

  • Lipidem delivers omega‑3‑acid triglycerides that are hydrolyzed to free fatty acids and glycerol, providing a dense caloric source. The fatty acids are incorporated into phospholipids of cell membranes, supporting membrane fluidity, signaling pathways, and synthesis of eicosanoids, while also serving as an energy substrate during total parenteral nutrition.

Side Effects

Lipidem may be associated with a range of infusion‑related reactions.

Common Side Effects

  • Hypertriglyceridemia: elevated serum triglyceride levels during therapy.
  • Fever or chills: transient temperature rise during infusion.
  • Infusion site reactions: erythema, pain, or swelling at the catheter site.
  • Nausea or headache: mild gastrointestinal or neurologic discomfort.

Serious or Rare Side Effects

  • Fat overload syndrome: severe hyperlipidaemia with hepatic and respiratory compromise.
  • Allergic reactions: anaphylaxis or severe hypersensitivity, especially in patients with soy or egg phospholipid allergy.
  • Pulmonary embolism: rare embolic events related to lipid particles.
  • Hepatic dysfunction: marked elevation of liver enzymes or cholestasis.
  • Thrombocytopenia: reduced platelet count potentially leading to bleeding.

Precautions & Warnings

When using Lipidem, clinicians should observe several safety measures.

  • Monitor triglyceride levels: check serum triglycerides regularly to avoid fat overload.
  • Assess liver function: perform hepatic enzyme tests before and during therapy.
  • Caution in hyperlipidaemia: adjust dosing or consider alternative lipid sources.
  • Avoid in known soy or egg phospholipid hypersensitivity: screen patients for allergies.
  • Adjust in impaired metabolism: reduce infusion rates for patients with compromised lipid clearance.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lipidem can interact with other agents that affect lipid metabolism or add to lipid load.

Major Interactions (Avoid)

  • Concurrent lipid emulsions: risk of cumulative fat overload.
  • Propofol infusion: both provide lipid calories, increasing overload risk.
  • High‑dose heparin: may exacerbate hypertriglyceridaemia.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: can raise serum triglycerides, requiring monitoring.
  • Beta‑blockers: may alter lipid metabolism, necessitating periodic lipid panels.
  • Diuretics: affect fluid balance; monitor for volume status during infusion.

Frequently Asked Questions

Lipidem is a parenteral lipid emulsion used as part of total parenteral nutrition to provide calories and essential fatty acids. It helps prevent essential fatty acid deficiency in patients who cannot receive enteral feeding, such as those in intensive care or with gastrointestinal dysfunction.

Omega-3-acid triglycerides are hydrolyzed after infusion to free fatty acids and glycerol, which serve as an energy source. The fatty acids are incorporated into cell‑membrane phospholipids, supporting membrane fluidity, signaling, and the synthesis of bioactive eicosanoids, thereby aiding metabolic and structural needs during parenteral nutrition.

The dose of Lipidem is individualized by the prescribing clinician based on the patient’s caloric requirements, lipid tolerance, and clinical condition. Dosage calculations consider factors such as body weight, total energy needs, and existing lipid levels, and are adjusted throughout therapy.

Safety data for Lipidem in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To order Lipidem, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and required import documentation.

Lipidem contains a blend of omega‑3‑acid triglycerides derived from refined soy‑bean oil and medium‑chain triglycerides, offering a balanced fatty‑acid profile. Compared with traditional soybean‑oil‑only emulsions, it may provide a higher proportion of omega‑3 fatty acids, potentially influencing inflammatory pathways and lipid metabolism, though clinical choice depends on patient‑specific factors.

Lipidem must be stored at 2‑8 °C, protected from light, and should never be frozen or shaken. Before use, inspect the emulsion for discoloration or separation. Keep the product in its original container until administration to maintain sterility and stability.

Lipidem is administered intravenously as an emulsion, typically via a central venous catheter. It is infused over a prescribed period, often as part of a total parenteral nutrition regimen, and the infusion rate is adjusted according to the patient’s metabolic response and tolerance.

Serious risks include fat overload syndrome, severe hypertriglyceridaemia, allergic reactions (especially in patients with soy or egg phospholipid sensitivity), pulmonary embolism, and hepatic dysfunction. Early recognition of symptoms such as respiratory distress, marked liver enzyme elevation, or sudden drops in platelet count is essential.

Lipidem should be avoided in patients with known hypersensitivity to soy‑bean oil, egg phospholipids, or any component of the emulsion. It is also contraindicated in individuals with severe hyperlipidaemia, uncontrolled fatty‑acid metabolism disorders, or those who have experienced a previous severe reaction to lipid emulsions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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