Product image of Lipidil (Fenofibrate (Nanonised)) supplied by GNH India

Lipidil

Active Ingredient:
Fenofibrate (Nanonised)
Origin:
EU

Lipidil (Fenofibrate (Nanonised))

Fenofibrate, the active ingredient in Lipidil, is a fibrate presented as a nanonised oral formulation for oral use. It is employed to lower elevated triglyceride levels and to improve lipid profiles in adults with hypertriglyceridemia or mixed dyslipidemia. It is indicated for patients at risk of pancreatitis due to severe triglyceride elevation and is often part of a comprehensive lipid‑lowering regimen that includes diet and exercise.

GNH India supplies Lipidil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches for global distribution.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Fenofibrate is a fibrate that acts on lipid metabolism to modify triglyceride and cholesterol levels.

  • Hypertriglyceridemia: reduces serum triglyceride concentrations to lower cardiovascular risk.
  • Mixed dyslipidemia: lowers triglycerides, modestly raises HDL‑cholesterol and reduces LDL‑cholesterol.
  • Prevention of pancreatitis associated with severe hypertriglyceridemia: decreases the likelihood of pancreatitis by maintaining triglyceride levels within safer limits.

How It Works

  • Fenofibrate activates peroxisome proliferator‑activated receptor alpha (PPARα), a nuclear transcription factor that up‑regulates genes involved in fatty‑acid β‑oxidation, reduces hepatic triglyceride synthesis, and enhances clearance of triglyceride‑rich lipoproteins, resulting in lowered plasma triglycerides and modest improvements in HDL‑ and LDL‑cholesterol levels.

Side Effects

Fenofibrate may cause a range of adverse reactions.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort.
  • Headache or dizziness.
  • Myalgia or mild muscle pain.

Serious or Rare Side Effects

  • Rhabdomyolysis, especially when combined with statins.
  • Hepatic dysfunction, indicated by elevated transaminases.
  • Severe skin reactions such as Stevens‑Johnson syndrome.
  • Acute pancreatitis.
  • Renal impairment in susceptible individuals.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Monitor liver function tests: obtain baseline values and repeat periodically.
  • Assess renal function: adjust or avoid use in severe renal impairment.
  • Evaluate for gallbladder disease: avoid in patients with active gallstones or biliary obstruction.
  • Review concomitant statin therapy: increased risk of myopathy requires careful monitoring.
  • Avoid in patients with known hypersensitivity to fenofibrate or other fibrates.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Fenofibrate can interact with several drug classes.

Major Interactions (Avoid)

  • Gemfibrozil: combined use markedly raises the risk of rhabdomyolysis.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase fenofibrate plasma concentrations.
  • High‑dose statins (especially simvastatin): heightened risk of muscle toxicity.

Moderate Interactions (Monitor Closely)

  • Anticoagulants such as warfarin: fenofibrate may enhance anticoagulant effect and raise INR.
  • Bile‑acid sequestrants: can reduce fenofibrate absorption, diminishing efficacy.
  • Oral hypoglycemic agents: fenofibrate may potentiate glucose‑lowering effects, requiring dose adjustment.

Frequently Asked Questions

Lipidil contains fenofibrate, a fibrate class medication indicated for the treatment of hypertriglyceridemia and mixed dyslipidemia. It helps lower elevated triglyceride levels and modestly improves overall lipid profiles, reducing the risk of cardiovascular complications associated with abnormal blood lipids.

Fenofibrate activates the nuclear receptor PPARα, which regulates genes involved in fatty‑acid oxidation and lipoprotein metabolism. This activation enhances the breakdown of triglycerides, reduces hepatic triglyceride synthesis, and promotes clearance of triglyceride‑rich particles, leading to lower plasma triglyceride concentrations.

The specific dose of Lipidil is determined by the prescribing healthcare professional based on the patient’s clinical condition, laboratory values, and response to therapy. Dosage adjustments may be required for renal or hepatic impairment, and the prescriber will provide individualized instructions.

The safety of fenofibrate in pregnancy and lactation has not been definitively established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To place an order, submit an enquiry on the Lipidil product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details, and any necessary import documentation.

Compared with statins, fenofibrate primarily lowers triglycerides and modestly raises HDL‑cholesterol, whereas statins are more potent at reducing LDL‑cholesterol. Fenofibrate is often used when triglyceride reduction is the primary goal or as an adjunct to statin therapy, but combined use requires careful monitoring for muscle toxicity.

Lipidil should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture and direct light to maintain stability and potency throughout its shelf life.

Lipidil is taken orally, usually with a meal to enhance absorption. The tablet should be swallowed whole with water and not chewed or crushed unless specifically directed by a healthcare professional.

The most serious risks include rhabdomyolysis (especially when combined with statins), severe hepatic dysfunction, acute pancreatitis, and rare but severe skin reactions such as Stevens‑Johnson syndrome. Patients should report unexplained muscle pain, dark urine, jaundice, or skin eruptions promptly.

Lipidil is contraindicated in individuals with known hypersensitivity to fenofibrate or other fibrates, those with active gallbladder disease, severe renal impairment, and patients with pre‑existing severe liver disease. It should also be avoided in patients taking gemfibrozil due to a high risk of muscle toxicity.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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