Product image of Lipiodol Ultra-Fluid (Ethiodized Oil) supplied by GNH India

Lipiodol Ultra-Fluid

Active Ingredient:
Ethiodized Oil
Origin:
EU

Lipiodol Ultra-Fluid (Ethiodized Oil)

Ethyiodized Oil, the active ingredient in Lipiodol Ultra-Fluid, is an iodinated oil‑based contrast media presented as a liquid for intralymphatic use. It provides radiopaque contrast to enhance visualization of lymphatic structures during diagnostic and interventional procedures.
GNH India supplies Lipiodol Ultra-Fluid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Guerbet

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Indications & Clinical Uses

Lipiodol Ultra-Fluid, an iodinated oil‑based contrast agent, is used in lymphatic imaging procedures.

  • Lymphangiography: Enables detailed visualization of lymphatic vessels and nodes for diagnostic assessment.
  • Detection of lymphatic leaks: Highlights sites of lymphatic leakage to guide therapeutic intervention.
  • Sentinel lymph node mapping: Provides contrast to identify sentinel nodes during oncologic surgery.

How It Works

  • Ethyiodized Oil contains a high concentration of iodine atoms that strongly attenuate X‑ray photons. After intralymphatic injection, the oil‑based formulation remains within the lymphatic channels, creating a persistent radiopaque column that delineates vessels and nodes on radiographic images, thereby improving anatomical detail and lesion detection.

Side Effects

Lipiodol Ultra-Fluid may cause a range of adverse reactions.

Common Side Effects

  • Injection site pain: mild discomfort at the site of administration.
  • Nausea or vomiting: transient gastrointestinal upset.
  • Mild fever: low‑grade temperature elevation.
  • Transient hypotension: temporary drop in blood pressure.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergy requiring immediate medical intervention.
  • Oil embolism: blockage of vessels by oil droplets, potentially affecting lungs or brain.
  • Tissue necrosis: localized tissue death at the injection site.
  • Severe hypotension: marked blood pressure decline needing treatment.
  • Renal impairment: worsening kidney function in susceptible patients.

Precautions & Warnings

Before using Lipiodol Ultra-Fluid, consider the following precautions.

  • Allergy assessment: verify no known iodine or oil allergy.
  • Renal function: evaluate kidney status prior to administration.
  • Pregnancy: avoid unless the clinical benefit outweighs potential risk.
  • Concurrent medications: review anticoagulant or thyroid therapy that may interact.
  • Store at ambient temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Lipiodol Ultra-Fluid can interact with other agents.

Major Interactions (Avoid)

  • Iodine‑containing medications: may increase total iodine load and risk toxicity.
  • Thyroid hormone therapy: can alter thyroid function test results.
  • Radiopharmaceuticals: may interfere with nuclear imaging interpretation.

Moderate Interactions (Monitor Closely)

  • Nephrotoxic drugs: monitor renal function when used together.
  • Diuretics: may affect fluid balance and contrast distribution.
  • Other contrast‑enhancing agents: consider cumulative iodine exposure.

Frequently Asked Questions

Lipiodol Ultra-Fluid is an iodinated oil‑based contrast medium used primarily for lymphangiography, detection of lymphatic leaks, and sentinel lymph node mapping. It is injected into the lymphatic system to provide clear radiographic images that help clinicians diagnose and plan treatment for lymphatic disorders.

Ethyiodized oil contains a high density of iodine atoms, which absorb X‑ray photons. When administered intralymphatically, the oil remains within lymphatic channels, creating a persistent radiopaque column that outlines vessels and nodes on X‑ray or CT images, thereby improving visualization of the lymphatic anatomy.

The dose of Lipiodol Ultra-Fluid is determined by the prescribing physician based on the specific imaging procedure, patient size, and clinical objectives. No fixed regimen is provided; the healthcare professional calculates the appropriate volume at the time of the intervention.

Safety data for Lipiodol Ultra-Fluid in pregnancy and lactation are limited. It is generally avoided during pregnancy unless the diagnostic benefit outweighs potential risks to the fetus. Breastfeeding mothers should consult their physician, as the product may be excreted in milk.

To order Lipiodol Ultra-Fluid, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials. The sales team then provides pricing, availability, shipping details (including any cold‑chain requirements), and assists with import documentation.

Compared with water‑soluble iodinated contrast agents, Lipiodol Ultra-Fluid is oil‑based, which gives it longer retention in the lymphatic system and higher radiopacity. This makes it especially useful for procedures requiring prolonged imaging, such as sentinel node mapping, but it may have a higher risk of oil‑related adverse events.

Store Lipiodol Ultra-Fluid at ambient temperature, preferably below 25 °C, in its original sealed container. Protect the product from direct sunlight, excessive heat, and moisture. Do not freeze or shake the vial before use, and keep it out of reach of children.

Lipiodol Ultra-Fluid is administered by intralymphatic injection under imaging guidance. A trained radiologist or interventional specialist injects the liquid directly into lymphatic vessels or nodes using a fine needle or catheter, allowing the contrast to flow through the lymphatic system for diagnostic imaging.

The most serious risks include severe allergic reactions such as anaphylaxis, oil embolism that can obstruct pulmonary or cerebral vessels, and tissue necrosis at the injection site. Patients should be monitored closely during and after administration for any signs of these complications.

Lipiodol Ultra-Fluid should be avoided in individuals with known hypersensitivity to iodine or oil‑based contrast agents, in patients with severe uncontrolled thyroid disease, and in those with compromised renal function where additional iodine load could be harmful. Contraindications must be confirmed by the treating physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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