Lipiodol Ultra Fluid (Ethyl Esters Of Iodised Fatty Acids From Poppyseed Oil)

Lipiodol Ultra Fluid, an iodinated oil‑based contrast agent, is employed in radiographic procedures that require intra‑arterial or intralymphatic contrast enhancement.

• Lymphangiography: enables detailed visualization of lymphatic vessels and nodes by providing high‑density iodine contrast.
• Hepatic tumor embolization: facilitates targeted delivery of embolic material and improves tumor delineation during interventional radiology.
• Vascular imaging procedures: enhances image contrast for intra‑arterial angiography and other vascular studies.

• Lipiodol Ultra Fluid delivers a high concentration of iodine within an oil‑based carrier that remains in the vascular or lymphatic space long enough to attenuate X‑ray beams. The iodine atoms absorb X‑rays, creating a radiopaque image that highlights the anatomy of interest, while the oil vehicle provides sustained retention and gradual dispersion in the targeted region.

Adverse reactions to Lipiodol Ultra Fluid may vary in frequency and severity.

Common Side Effects

• Injection site pain: mild discomfort at the site of administration.
• Transient warmth or flushing: brief sensation of heat.
• Nausea or vomiting: mild gastrointestinal upset.
• Headache: temporary mild headache.
• Mild allergic reaction: rash or itching.

Serious or Rare Side Effects

• Severe allergic reaction (anaphylaxis): rapid onset of breathing difficulty, hypotension, or swelling.
• Oil embolism: pulmonary or systemic embolic events.
• Acute thyroid dysfunction: hyperthyroidism or hypothyroidism due to iodine load.
• Renal impairment: acute kidney injury in susceptible patients.
• Cardiovascular collapse: severe hypotension or arrhythmia.

Prior to using Lipiodol Ultra Fluid, clinicians should evaluate patient-specific factors and adhere to handling guidelines.

• Allergy assessment: review history of reactions to iodinated contrast or iodine.
• Thyroid function: assess for hyperthyroidism or thyroid disease before administration.
• Renal function: evaluate kidney function, especially in patients with pre‑existing impairment.
• Pregnancy and lactation: consider risks as safety data are limited; use only if essential.
• Pediatric use: adjust dosing and monitor closely in children.
• Store at room temperature: keep in original container, protect from light and moisture.

Lipiodol Ultra Fluid may interact with other agents that affect iodine load or organ function.

Major Interactions (Avoid)

• Concurrent iodinated contrast agents: cumulative iodine may increase risk of thyroid dysfunction.
• Thyroid hormone therapy: may exacerbate hyperthyroid effects when combined with high iodine load.
• Radiopharmaceuticals containing iodine: can interfere with diagnostic accuracy.

Moderate Interactions (Monitor Closely)

• Anticoagulants (e.g., warfarin): monitor for bleeding if oil embolism occurs.
• Beta‑blockers: may mask symptoms of anaphylaxis.
• Diuretics and NSAIDs: increase risk of renal impairment; monitor kidney function.
• Chemotherapeutic agents: consider additive toxicity in hepatic embolization procedures.