Lipiodol Ultra Fluide (Ethyl Esters Of Iodised Fatty Acids From Poppyseed Oil)

Lipiodol Ultra Fluide is an iodinated contrast medium used in diagnostic imaging procedures that require enhanced radiopacity.

• Lymphangiography: visualises lymphatic vessels and nodes for disease assessment.
• Hysterosalpingography: delineates uterine cavity and fallopian tube patency in fertility evaluation.
• Arterial embolization procedures: improves visualization of vascular anatomy to guide embolic material delivery.

• The ethyl esters of iodised fatty acids contain a high concentration of iodine atoms, which absorb X‑ray photons and create radiopaque contrast. When administered intra‑arterially, intracervically, or intralymphatically, the agent remains within the vascular or lymphatic space, enhancing the differentiation of anatomical structures on X‑ray‑based imaging modalities such as fluoroscopy and CT.

Adverse reactions may occur following administration of Lipiodol Ultra Fluide.

Common Side Effects

• Warmth or flushing sensation at the injection site.
• Mild nausea or vomiting.
• Transient headache.
• Temporary hypotension.
• Mild pain or discomfort in the administered area.
• Minor allergic skin reactions such as rash.

Serious or Rare Side Effects

• Severe allergic reaction or anaphylaxis.
• Acute renal impairment, especially in patients with pre‑existing kidney disease.
• Pulmonary edema or respiratory distress.
• Cardiac arrhythmias or severe hypotension.
• Thyroid dysfunction due to iodine load.
• Persistent pain or tissue necrosis at the injection site.

Prior to using Lipiodol Ultra Fluide, clinicians should consider several safety measures.

• Assess renal function: evaluate serum creatinine and eGFR before administration.
• Review iodine allergy history: avoid in patients with known hypersensitivity to iodinated contrast.
• Use the lowest effective volume: limit exposure to reduce adverse events.
• Monitor vital signs: observe blood pressure and heart rate during and after injection.
• Avoid in uncontrolled hyperthyroidism: excess iodine may exacerbate thyroid activity.
• Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Lipiodol Ultra Fluide may interact with other medications, requiring careful management.

Major Interactions (Avoid)

• Concurrent nephrotoxic drugs (e.g., aminoglycosides, high‑dose NSAIDs): increase risk of renal injury.
• Radioactive iodine therapy: excess iodine can interfere with therapeutic efficacy.

Moderate Interactions (Monitor Closely)

• Diuretics: may potentiate volume depletion and renal effects.
• ACE inhibitors or ARBs: monitor blood pressure and renal function.
• Metformin: assess renal function and consider temporary discontinuation to prevent lactic acidosis.
• Thyroid hormone replacement: monitor thyroid function tests for iodine‑induced changes.
• Beta‑blockers: observe for altered cardiovascular response during administration.