Product image of Lipiodol Ultra Fluide (Ethyl Esters Of Iodised Fatty Acids From Poppyseed Oil) supplied by GNH India

Lipiodol Ultra Fluide

Active Ingredient:
Ethyl Esters Of Iodised Fatty Acids From Poppyseed Oil
Origin:
EU

Lipiodol Ultra Fluide (Ethyl Esters Of Iodised Fatty Acids From Poppyseed Oil)

Ethyl esters of iodised fatty acids, the active ingredient in Lipiodol Ultra Fluide, is a iodinated contrast media (oil‑based) presented as a liquid for intraarterial and intralymphatic use. It provides radiopaque contrast for imaging procedures such as lymphangiography and hepatic tumor embolization.

GNH India supplies Lipiodol Ultra Fluide as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, meeting regulatory standards and ensuring product integrity throughout the supply chain with consistent quality control.

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Indications & Clinical Uses

Lipiodol Ultra Fluide, an oil‑based iodinated contrast agent, is employed in radiographic procedures that require vascular or lymphatic imaging.

  • Lymphangiography: Provides high‑contrast visualization of lymphatic vessels and nodes for diagnostic imaging.
  • Hepatic tumor embolization: Enhances radiopacity of embolic material to improve targeting of liver lesions during interventional radiology.
  • Vascular imaging: Supplies radiopaque contrast for intra‑arterial studies where oil‑based agents are preferred, facilitating detailed vessel assessment.

How It Works

  • The ethyl esters of iodised fatty acids contain a high concentration of iodine bound to fatty acid chains, making the solution highly radiopaque. After intra‑arterial or intralymphatic injection, the oily droplets remain within vascular and lymphatic spaces, providing sustained contrast that enhances X‑ray or CT visualization of vessels and lesions.

Side Effects

Adverse reactions to Lipiodol Ultra Fluide are generally related to its oily nature and iodine content.

Common Side Effects

  • Injection site pain: mild discomfort at the site of intra‑arterial or intralymphatic administration.
  • Nausea or vomiting: transient gastrointestinal upset occurring shortly after the procedure.
  • Flushing or warmth sensation: brief feeling of warmth or skin flushing due to iodine release.

Serious or Rare Side Effects

  • Allergic reaction: urticaria, bronchospasm, or anaphylaxis requiring immediate medical intervention.
  • Oil embolism: migration of the oily contrast into pulmonary or systemic circulation causing respiratory compromise.
  • Renal impairment: acute kidney injury in susceptible patients, especially with pre‑existing renal disease.

Precautions & Warnings

When using Lipiodol Ultra Fluide, consider the following precautions:

  • Pregnancy: use only if clearly needed, as safety data are limited.
  • Renal function: assess kidney function before administration, adjust use in impaired patients.
  • Allergy history: screen for iodine or contrast media hypersensitivity.
  • Thyroid disease: monitor thyroid function because iodine load may affect thyroid.
  • Concurrent embolic agents: avoid mixing with incompatible substances.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Lipiodol Ultra Fluide may interact with other agents as follows:

Major Interactions (Avoid)

  • Iodine‑containing medications: concurrent high‑dose iodine can increase risk of thyroid dysfunction.
  • Hyperosmolar contrast agents: co‑administration may exacerbate renal toxicity.
  • Thyroid hormone therapy: may amplify iodine load, affecting thyroid status.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: oil‑based contrast may potentiate bleeding risk if embolization causes vessel injury.
  • Nephrotoxic drugs (e.g., aminoglycosides, NSAIDs): monitor renal function when used together.
  • Beta‑blockers: may mask signs of contrast‑induced hypertension.

Frequently Asked Questions

Lipiodol Ultra Fluide is an oil‑based iodinated contrast agent used in radiographic procedures such as lymphangiography, hepatic tumor embolization and other intra‑arterial vascular imaging where high radiopacity is required.

The ethyl esters contain a high concentration of iodine bound to fatty‑acid chains, making the solution radiopaque. After intra‑arterial or intralymphatic injection, the oily droplets remain in the vascular or lymphatic spaces, providing sustained contrast that enhances X‑ray or CT visualization of vessels and lesions.

The dose is determined by the prescribing physician based on the specific imaging study, the vascular territory, and patient factors. The amount administered is calculated to achieve adequate radiopacity while minimizing exposure, and it is delivered under imaging guidance by a qualified radiologist or interventionalist.

Safety data in pregnant or lactating women are limited, and the product is classified as contraindicated unless clearly necessary. Iodine can cross the placenta and enter breast milk, potentially affecting fetal or infant thyroid function, so use only after careful risk‑benefit assessment by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Unlike water‑soluble agents, Lipiodol Ultra Fluide is oil‑based, providing prolonged retention in vascular and lymphatic spaces and higher radiopacity for certain embolization procedures. However, it may have a higher risk of oil embolism and requires careful handling, whereas water‑soluble agents are cleared more rapidly and are generally used for routine angiography.

Lipiodol Ultra Fluide should be stored at ambient temperature, preferably below 25 °C, in its original sealed container. It must be protected from direct sunlight, moisture and extreme temperature fluctuations. The product should not be frozen, and any opened vial should be used promptly according to the manufacturer’s stability guidelines.

The product is supplied as a sterile liquid for intra‑arterial or intralymphatic injection. Administration is performed by a qualified radiologist or interventional specialist under imaging guidance, using appropriate catheters or needles. The volume injected is tailored to the imaging objective, and the procedure is conducted in a setting equipped for monitoring of vital signs and potential adverse reactions.

The most serious risks include severe allergic reactions such as anaphylaxis, oil embolism leading to pulmonary or systemic compromise, and acute kidney injury in patients with pre‑existing renal impairment. Prompt recognition and management of these events are essential, and patients should be monitored closely during and after the procedure.

Patients with known hypersensitivity to iodine‑containing contrast media, a history of severe allergic reactions, uncontrolled thyroid disease, or severe renal insufficiency should generally avoid Lipiodol Ultra Fluide. Additionally, it is contraindicated in pregnant women unless the diagnostic benefit outweighs the potential risk to the fetus, and in individuals where oil‑based embolic agents are contraindicated.

Published by

GNH India Pharmaceuticals Limited

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Last updated:

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