Lipiodol Ultra Fluide (Ethyl Esters Of Iodised Fatty Acids From Poppyseed Oil)

Lipiodol Ultra Fluide, an oil‑based iodinated contrast agent, is used in radiographic procedures that require enhanced visualization of vascular, lymphatic and spinal structures.

• Angiography: provides high‑contrast visualization of blood vessels to aid diagnostic and interventional procedures.
• Lymphography: enhances lymphatic channels for detailed mapping and disease assessment.
• Myelography: supplies clear contrast of the spinal canal and nerve roots during imaging.
• Tumor embolization: delivers radiopaque material to occlude tumor‑feeding vessels while allowing real‑time imaging.

• Ethyl esters of iodised fatty acids contain a high concentration of iodine atoms that strongly attenuate X‑ray photons. When injected into the vascular, lymphatic, or muscular compartments, the iodine‑rich oil creates a radiopaque column that increases X‑ray absorption, thereby improving the contrast between the target structure and surrounding tissues during imaging procedures.

Adverse reactions may occur following administration of Lipiodol Ultra Fluide.

Common Side Effects

• Pain or burning at the injection site.
• Nausea or vomiting.
• Transient flushing or warmth sensation.
• Headache.
• Mild fever or chills.
• Localized swelling.

Serious or Rare Side Effects

• Severe allergic reaction or anaphylaxis.
• Pulmonary embolism from inadvertent intravascular migration.
• Tissue necrosis at the injection site.
• Acute thyroid dysfunction due to iodine load.
• Cardiovascular instability or arrhythmia.
• Persistent severe pain requiring medical intervention.

Prior to using Lipiodol Ultra Fluide, clinicians should consider several safety measures.

• Assess iodine allergy: verify patient has no known hypersensitivity to iodine‑containing agents.
• Check renal function: evaluate kidney status as impaired function may increase risk of adverse events.
• Avoid in hyperthyroidism: high iodine load can exacerbate thyroid disease.
• Use lowest effective volume: limit the amount injected to the minimum required for adequate imaging.
• Monitor for immediate hypersensitivity: observe the patient closely during and after administration.
• Store at room temperature: keep in the original container, protect from light and moisture.

Lipiodol Ultra Fluide may interact with other medications or substances that affect iodine balance or organ function.

Major Interactions (Avoid)

• Iodine‑containing drugs (e.g., amiodarone): may increase total iodine exposure.
• Thyroid hormone therapy: risk of thyroid dysfunction.
• Radiopharmaceuticals: can interfere with nuclear imaging results.

Moderate Interactions (Monitor Closely)

• Nephrotoxic agents (e.g., aminoglycosides): monitor renal function.
• Diuretics: may alter fluid balance and contrast distribution.
• Anticoagulants: observe for bleeding if embolization is performed.