Product image of Lipiodol Ultra-Fluide (Ethyl Esters Of Iodised Fatty Acids From Poppyseed Oil) supplied by GNH India

Lipiodol Ultra-Fluide

Active Ingredient:
Ethyl Esters Of Iodised Fatty Acids From Poppyseed Oil
Origin:
EU

Lipiodol Ultra-Fluide (Ethyl Esters Of Iodised Fatty Acids From Poppyseed Oil)

Ethyl esters of iodised fatty acids, the active ingredient in Lipiodol Ultra-Fluide, is an iodinated contrast media presented as an oil‑based solution for intralymphatic use. It enhances radiographic visualization of lymphatic structures and is employed in diagnostic procedures such as lymphangiography, detection of lymphatic leaks, and sentinel lymph node mapping.

GNH India supplies Lipiodol Ultra-Fluide as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Guerbet

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Indications & Clinical Uses

Lipiodol Ultra-Fluide, an iodinated contrast media used in lymphatic imaging, is indicated for the following clinical applications:

  • Lymphangiography: provides detailed radiopaque visualization of lymphatic vessels and nodes.
  • Detection of lymphatic leaks: highlights sites of lymphatic leakage for diagnostic and interventional planning.
  • Sentinel lymph node mapping: delineates sentinel nodes to guide surgical oncology procedures.

How It Works

  • Ethyl esters of iodised fatty acids are oil‑based molecules with a high iodine content. After intralymphatic injection, the iodine atoms absorb X‑ray photons, creating a radiopaque contrast that outlines lymphatic channels and nodes on fluoroscopic or CT imaging. The oily carrier slows diffusion, allowing prolonged and detailed visualization of the lymphatic system.

Side Effects

Adverse reactions to Lipiodol Ultra-Fluide may occur following intralymphatic administration.

Common Side Effects

  • Pain at injection site: mild discomfort or tenderness.
  • Local erythema: redness around the injection area.
  • Transient fever: low‑grade temperature rise lasting a few hours.
  • Nausea: occasional mild nausea reported.

Serious or Rare Side Effects

  • Embolization: blockage of lymphatic or vascular structures.
  • Allergic reaction: urticaria, bronchospasm, or anaphylaxis.
  • Pulmonary oil embolism: rare but severe respiratory compromise.
  • Tissue necrosis: localized tissue death at injection site.

Precautions & Warnings

When using Lipiodol Ultra-Fluide, clinicians should observe the following precautions.

  • Patient assessment: evaluate for iodine allergy or prior contrast reactions.
  • Renal function: consider renal impairment as iodine load may affect kidney function.
  • Pregnancy status: avoid use unless benefits outweigh potential risks.
  • Breastfeeding: discontinue breastfeeding if administered to lactating patients.
  • Injection technique: use aseptic technique and proper intralymphatic placement to minimize complications.
  • Store at ambient temperature: keep below 25 °C, protect from light and moisture in original container.

Avoid Interactions

Lipiodol Ultra-Fluide may interact with the following agents.

Major Interactions (Avoid)

  • Iodine‑containing medications: concurrent high‑dose iodine compounds can increase total iodine load and risk of toxicity.
  • Anticoagulants: may exacerbate bleeding if vascular injury occurs during injection.

Moderate Interactions (Monitor Closely)

  • Thyroid hormones: excess iodine can alter thyroid function tests.
  • Diuretics: may affect renal clearance of iodine.
  • Radiopharmaceuticals: overlapping imaging agents can interfere with diagnostic interpretation.

Frequently Asked Questions

Lipiodol Ultra-Fluide is an iodinated contrast agent used primarily in diagnostic imaging of the lymphatic system. It is administered intralymphatically to perform lymphangiography, detect lymphatic leaks, and assist in sentinel lymph node mapping during oncologic procedures.

The ethyl esters of iodised fatty acids contain a high concentration of iodine atoms. When injected, the iodine absorbs X‑ray photons, creating a radiopaque image that outlines lymphatic vessels and nodes, while the oil base slows diffusion for extended visualization.

The dose of Lipiodol Ultra-Fluide is determined by the prescribing physician based on the specific imaging protocol, patient size, and clinical indication. No fixed regimen is provided; the prescriber sets the appropriate volume for each procedure.

Safety data for Lipiodol Ultra-Fluide in pregnancy and lactation are limited. It should be avoided unless the diagnostic benefit clearly outweighs potential risks to the fetus or infant, and the decision should be made by the treating physician.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with water‑soluble iodinated agents, Lipiodol Ultra-Fluide’s oil‑based formulation provides longer retention in lymphatic channels, yielding clearer and more persistent images for lymphangiography. However, its intralymphatic route and oil base differ from intravenous contrast media used for vascular imaging.

Store Lipiodol Ultra-Fluide at ambient temperature, preferably below 25 °C. Keep the container tightly closed, protect it from direct sunlight, moisture and extreme temperature fluctuations to maintain product stability.

The product is administered by a qualified healthcare professional via intralymphatic injection. The injection is performed under imaging guidance to ensure accurate placement within the lymphatic vessels or nodes for optimal contrast enhancement.

Serious risks include embolization of lymphatic or vascular structures, severe allergic reactions such as anaphylaxis, pulmonary oil embolism, and localized tissue necrosis at the injection site. Immediate medical attention is required if any of these events occur.

Patients with known iodine allergy, severe renal impairment, uncontrolled thyroid disease, or those who are pregnant or breastfeeding without a clear clinical justification should generally avoid Lipiodol Ultra-Fluide. The prescribing clinician must assess suitability on an individual basis.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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