Product image of Lipiodol Ultra-Fluide (Ethyl Esters Of Iodised Fatty Acids From Poppyseed Oil) supplied by GNH India

Lipiodol Ultra-Fluide

Active Ingredient:
Ethyl Esters Of Iodised Fatty Acids From Poppyseed Oil
Origin:
EU

Lipiodol Ultra-Fluide (Ethyl Esters Of Iodised Fatty Acids From Poppyseed Oil)

Ethyl esters of iodised fatty acids from poppyseed oil, the active ingredient in Lipiodol Ultra-Fluide, is an iodinated contrast media presented as a sterile oil for intralymphatic use. It provides radiopaque imaging enhancement for lymphatic, joint and tumor‑related procedures in adult patients.

GNH India supplies Lipiodol Ultra-Fluide as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Guerbet

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Indications & Clinical Uses

Lipiodol Ultra-Fluide is used as an iodinated contrast agent for imaging and interventional procedures involving the lymphatic system and other targeted structures.

  • Lymphangiography: visualises lymphatic vessels and nodes to assess obstruction or leakage.
  • Arthrography: enhances joint space imaging to detect cartilage defects, tears or inflammatory changes.
  • Tumor embolization: provides contrast during arterial embolisation of hepatic or other solid tumours to guide catheter placement.
  • Radiographic contrast enhancement: improves X‑ray visibility of vascular or soft‑tissue structures during diagnostic studies.

How It Works

  • The ethyl esters of iodised fatty acids deliver a high concentration of iodine atoms that strongly absorb X‑ray photons. When injected intralymphatically, the iodine‑rich oil remains within the targeted vascular or lymphatic compartment, creating a radiopaque outline that accentuates anatomical detail on fluoroscopic or CT imaging, thereby facilitating accurate diagnosis and procedural guidance.

Side Effects

Adverse reactions may occur following intralymphatic administration of Lipiodol Ultra-Fluide.

Common Side Effects

  • Warmth or flushing at the injection site: transient sensation of heat.
  • Mild pain or discomfort: localized soreness during or after injection.
  • Nausea or vomiting: occasional gastrointestinal upset.
  • Mild allergic skin reaction: erythema or urticaria at the site.

Serious or Rare Side Effects

  • Severe hypersensitivity reaction: anaphylaxis requiring emergency treatment.
  • Pulmonary embolism: rare migration of oil droplets to the lungs.
  • Renal impairment: contrast‑induced nephropathy in susceptible patients.
  • Cardiovascular collapse: hypotension or arrhythmia in extreme cases.

Precautions & Warnings

Prior to using Lipiodol Ultra-Fluide, clinicians should consider several safety measures.

  • Assess iodine allergy: screen patients for known hypersensitivity to iodinated agents.
  • Evaluate renal function: check serum creatinine and eGFR, especially in at‑risk individuals.
  • Use lowest effective volume: limit the amount injected to reduce systemic exposure.
  • Monitor vital signs: observe blood pressure, heart rate and oxygen saturation during administration.
  • Avoid use in uncontrolled hyperthyroidism: excess iodine may exacerbate thyroid hormone release.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Lipiodol Ultra-Fluide may interact with other medications or agents that affect iodine handling or renal function.

Major Interactions (Avoid)

  • Thyroid hormone therapy: excess iodine can alter hormone levels.
  • Other iodinated contrast agents: cumulative iodine load increases risk of toxicity.
  • Nephrotoxic drugs (e.g., aminoglycosides, amphotericin B): may potentiate renal injury.

Moderate Interactions (Monitor Closely)

  • Diuretics: may affect fluid balance and contrast distribution.
  • ACE inhibitors or ARBs: can predispose to contrast‑induced nephropathy.
  • NSAIDs: may impair renal perfusion when combined with contrast media.

Frequently Asked Questions

Lipiodol Ultra-Fluide is an iodinated contrast medium employed primarily for lymphangiography, arthrography, tumor embolization procedures and general radiographic contrast enhancement. It is injected intralymphatically to provide clear X‑ray visualization of lymphatic channels, joint spaces, and vascular structures during diagnostic and interventional radiology.

The active ingredient, ethyl esters of iodised fatty acids from poppyseed oil, contains a high density of iodine atoms. Iodine strongly absorbs X‑ray photons, creating a radiopaque image. When the oil is introduced into the lymphatic or vascular system, it remains localized, outlining the anatomy and improving contrast on fluoroscopic or CT scans.

The dosage of Lipiodol Ultra-Fluide is determined by the prescribing physician based on the specific imaging study, patient size, and clinical indication. The prescriber selects the appropriate volume and concentration to achieve optimal contrast while minimizing exposure.

Safety data for Lipiodol Ultra-Fluide in pregnancy and lactation are limited. Because the product contains iodine, which can affect fetal thyroid function, it should be used only if clearly needed and after a risk‑benefit assessment by the healthcare provider. Breastfeeding mothers should consult their physician before exposure.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Lipiodol Ultra-Fluide is an oil‑based, iodine‑rich formulation that remains within the lymphatic or vascular compartment longer than water‑soluble contrast media, making it especially useful for lymphangiography and embolization. Compared with aqueous agents, it provides prolonged imaging windows but may have a higher risk of oil‑related adverse events, requiring careful patient selection.

Lipiodol Ultra-Fluide should be stored at ambient temperature, preferably below 25 °C. Keep the vial in its original packaging, protect it from moisture, direct sunlight and extreme temperatures. Do not freeze the product, and ensure the container is sealed to prevent contamination.

The product is administered by a qualified healthcare professional via intralymphatic injection. The sterile oil is injected directly into the targeted lymphatic channel or vascular bed under imaging guidance. Proper aseptic technique and real‑time monitoring are essential to ensure accurate delivery and patient safety.

Serious risks include severe hypersensitivity reactions such as anaphylaxis, pulmonary embolism from oil migration, contrast‑induced nephropathy, and cardiovascular collapse. Immediate medical intervention is required if any of these events occur. Patients should be monitored closely during and after administration.

Patients with a known allergy to iodine‑containing contrast agents, uncontrolled hyperthyroidism, severe renal impairment, or those who have had prior severe reactions to oil‑based contrast media should generally avoid Lipiodol Ultra-Fluide. The prescribing clinician must evaluate each individual’s medical history before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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