Lipoplus (Omega-3-Acid Triglycerides, Soya-Bean Oil Refined, Triglycerides, Medium Chain)

Lipoplus is used in clinical situations where intravenous lipid nutrition is required.

• Patients requiring parenteral nutrition: provides essential fatty acids and calories when oral or enteral intake is not possible.
• Severe malnutrition: helps restore energy balance and fatty acid stores in individuals with profound nutritional deficits.
• Post‑operative or critically ill patients unable to receive enteral feeding: supports metabolic needs during recovery or intensive care.

• Lipoplus delivers a mixture of long‑chain and medium‑chain triglycerides, including omega‑3 fatty acids, directly into the bloodstream. The emulsion is hydrolyzed by lipases, releasing free fatty acids that are incorporated into cell membranes, serve as energy substrates, and modulate inflammatory pathways, thereby meeting caloric and essential fatty‑acid requirements of patients receiving parenteral nutrition.

Lipoplus may be associated with a range of infusion‑related reactions.

Common Side Effects

• Hypertriglyceridaemia: elevated blood triglyceride levels during therapy.
• Fever or chills: transient temperature rise during infusion.
• Infusion site reactions: erythema, pain, or swelling at the catheter site.
• Elevated liver enzymes: mild increases in hepatic transaminases.

Serious or Rare Side Effects

• Fat overload syndrome: severe metabolic disturbance with hepatic dysfunction.
• Allergic reactions: urticaria, bronchospasm, or anaphylaxis.
• Thrombocytopenia: reduced platelet count in susceptible patients.
• Pulmonary embolism: rare but potentially life‑threatening clot formation.

When using Lipoplus, clinicians should observe specific safety measures.

• Monitor triglyceride levels: check serum triglycerides regularly to avoid hypertriglyceridaemia.
• Assess liver function: perform periodic liver enzyme tests during prolonged therapy.
• Observe for signs of infection: watch infusion sites for redness or discharge.
• Adjust dose in renal or hepatic impairment: consider reduced infusion rates.
• Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Lipoplus can interact with other agents that affect lipid metabolism or coagulation.

Major Interactions (Avoid)

• Concurrent lipid emulsions: may cause excessive lipid load and fat overload syndrome.
• Propofol infusion: both provide lipid calories and can precipitate hypertriglyceridaemia.

Moderate Interactions (Monitor Closely)

• Warfarin or other anticoagulants: omega‑3 fatty acids may enhance anticoagulant effect.
• High‑dose heparin: can further increase triglyceride levels.
• Other omega‑3 supplements: risk of additive effects on bleeding time.