Product image of Lipovast (Atorvastatin) supplied by GNH India

Lipovast

Active Ingredient:
Atorvastatin
Origin:
EU

Lipovast (Atorvastatin)

Atorvastatin, the active ingredient in Lipovast, is a HMG‑CoA reductase inhibitor presented as an oral tablet for oral use. It lowers elevated cholesterol and is used in patients with hypercholesterolemia and related cardiovascular risk.

GNH India supplies Lipovast as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Anfarm Hellas Sa

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Indications & Clinical Uses

  • Atorvastatin is a statin that targets lipid metabolism disorders.
  • Hypercholesterolemia: reduces LDL‑cholesterol and total cholesterol levels.
  • Mixed dyslipidemia: improves overall lipid profile by lowering triglycerides and raising HDL‑cholesterol.
  • Primary prevention of cardiovascular disease: decreases the risk of myocardial infarction, stroke and cardiovascular death.
  • Secondary prevention of cardiovascular disease: reduces recurrence of cardiovascular events in patients with established disease.

How It Works

  • Atorvastatin competitively inhibits HMG‑CoA reductase, the key enzyme in the hepatic mevalonate pathway responsible for cholesterol synthesis. This inhibition lowers intracellular cholesterol, prompting up‑regulation of LDL receptors on hepatocyte surfaces, which enhances clearance of circulating LDL particles and results in reduced plasma LDL‑cholesterol and total cholesterol levels.

Side Effects

Common Side Effects

  • Muscle aches or weakness
  • Elevated liver enzymes (ALT, AST)
  • Gastrointestinal discomfort such as nausea or abdominal pain
  • Headache

Serious or Rare Side Effects

  • Rhabdomyolysis, a severe muscle breakdown that can lead to renal failure
  • Acute liver injury, presenting with jaundice or severe enzyme elevation
  • Allergic reactions, including rash, pruritus, angioedema or anaphylaxis

Precautions & Warnings

  • When prescribing Lipovast, clinicians should consider several safety measures.
  • Monitor liver function: baseline and periodic liver enzyme testing is recommended.
  • Assess muscle symptoms: discontinue if unexplained muscle pain occurs with elevated creatine kinase.
  • Avoid in pregnancy: contraindicated due to fetal risk (Category X).
  • Use caution in renal impairment: dose adjustment may be required.
  • Drug interactions: review concomitant medications for CYP3A4 inhibitors.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture.

Avoid Interactions

Atorvastatin may interact with a range of medicines; careful review is essential.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole): can markedly increase atorvastatin exposure.
  • Grapefruit juice: may raise plasma concentrations and risk of toxicity.
  • Cyclosporine: enhances risk of myopathy and rhabdomyolysis.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (e.g., warfarin): may potentiate anticoagulant effect, requiring INR monitoring.
  • Antidiabetic agents: may necessitate adjustment of glucose‑lowering therapy.
  • Niacin: combined use can increase the likelihood of muscle toxicity.

Frequently Asked Questions

Lipovast contains the statin atorvastatin and is prescribed to lower elevated LDL‑cholesterol and total cholesterol. It is indicated for hypercholesterolemia, mixed dyslipidemia, and for both primary and secondary prevention of cardiovascular events such as heart attack and stroke.

Atorvastatin blocks the enzyme HMG‑CoA reductase, which is essential for cholesterol synthesis in the liver. By reducing cholesterol production, liver cells increase the number of LDL receptors, enhancing removal of LDL particles from the bloodstream and thereby lowering circulating cholesterol levels.

The dose of Lipovast is individualized by the prescribing clinician based on the patient’s cholesterol levels, cardiovascular risk, and tolerance. The prescriber determines the appropriate strength and dosing schedule, which may be adjusted over time according to therapeutic response and safety monitoring.

Lipovast is classified as pregnancy category X, meaning it is contraindicated during pregnancy because of potential fetal harm. It is also not recommended for breastfeeding mothers, as atorvastatin can be excreted in breast milk and may affect the infant.

To order Lipovast, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lipovast (atorvastatin) is a high‑potency statin with a long half‑life, offering strong LDL‑cholesterol reduction at relatively low doses. Compared with older statins such as simvastatin, atorvastatin often achieves greater lipid lowering and has a well‑characterized safety profile, though individual response and tolerability may vary.

Lipovast tablets should be stored at ambient temperature, preferably below 25 °C. Keep the medication in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Lipovast is taken orally as a whole tablet, with or without food. Swallow the tablet whole with a glass of water; do not crush, chew, or split the tablet unless specifically instructed by a healthcare professional.

The most serious adverse reactions include rhabdomyolysis (severe muscle breakdown), acute liver injury, and severe allergic responses such as angioedema. Patients should promptly report unexplained muscle pain, dark urine, jaundice, or signs of an allergic reaction to their healthcare provider.

Lipovast should not be used by individuals who are pregnant, have active liver disease, have a known hypersensitivity to atorvastatin or any excipients, or are taking contraindicated medications such as strong CYP3A4 inhibitors. Clinicians should also exercise caution in patients with severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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