Product image of Lopinavir / Ritonavir Sun (Lopinavir, Ritonavir) supplied by GNH India

Lopinavir / Ritonavir Sun

Active Ingredient:
Lopinavir, Ritonavir
Origin:
EU

Lopinavir / Ritonavir Sun (Lopinavir, Ritonavir)

Lopinavir, the active ingredient in Lopinavir / Ritonavir Sun, is a protease inhibitor presented as an oral tablet for oral use, combined with ritonavir, a pharmacokinetic enhancer, to treat HIV‑1 infection in adults and children. The combination inhibits viral replication by blocking HIV‑1 protease and increasing lopinavir plasma levels.

GNH India supplies Lopinavir / Ritonavir Sun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product meets EU quality standards and is distributed through regulated channels to ensure consistent availability for antiretroviral programmes.

Manufacturer / TM Owner

Sun Pharmaceutical Industries Europe B.V.

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Indications & Clinical Uses

Lopinavir/ritonavir is indicated for HIV‑1 infection as part of combination antiretroviral therapy.

  • HIV‑1 infection (adults): reduces viral load when used with other antiretrovirals.
  • HIV‑1 infection (children): provides pediatric dosing options within fixed‑dose combinations.
  • HIV‑1 infection (treatment‑experienced patients): offers an option for patients with resistance to other protease inhibitors.

How It Works

  • Lopinavir binds to the active site of HIV‑1 protease, preventing cleavage of viral polyproteins and thereby blocking maturation of infectious virions. Ritonavir inhibits CYP3A4 metabolism, raising lopinavir plasma concentrations and prolonging its antiviral effect, resulting in sustained suppression of HIV replication.

Side Effects

Common and serious adverse reactions have been reported with lopinavir/ritonavir therapy.

Common Side Effects

  • Diarrhoea: frequent loose stools.
  • Nausea and vomiting: gastrointestinal discomfort.
  • Abdominal pain: cramping or discomfort.
  • Headache: mild to moderate intensity.
  • Elevated triglycerides: increase in blood lipid levels.

Serious or Rare Side Effects

  • Hepatotoxicity: liver enzyme elevations or hepatitis.
  • Severe allergic reactions: rash, angioedema, or anaphylaxis.
  • Pancreatitis: inflammation of the pancreas.
  • QT prolongation: cardiac rhythm disturbances.
  • Stevens‑Johnson syndrome: severe skin reaction.

Precautions & Warnings

When prescribing lopinavir/ritonavir, clinicians should observe several precautionary measures.

  • Liver function monitoring: assess baseline enzymes and repeat periodically.
  • Lipid profile assessment: monitor for hypertriglyceridaemia.
  • Drug resistance evaluation: ensure adherence to the full regimen.
  • Pregnancy considerations: limited safety data; weigh benefits against potential risks.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Lopinavir/ritonavir interacts with several medicines through CYP3A4 modulation and other pathways.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine, St. John’s wort): may markedly reduce lopinavir levels.
  • Medications that prolong QT interval (e.g., haloperidol, quinidine): increased risk of cardiac arrhythmia.
  • Co‑administration with other high‑dose protease inhibitors: risk of toxicity.

Moderate Interactions (Monitor Closely)

  • Statins (simvastatin, lovastatin): increased myopathy risk; dose adjustment required.
  • Oral contraceptives: reduced efficacy; consider alternative contraception.
  • Warfarin: possible alteration of INR; monitor coagulation parameters.
  • Azole antifungals (ketoconazole, itraconazole): may raise lopinavir exposure; monitor for adverse effects.

Frequently Asked Questions

Lopinavir / Ritonavir Sun is used as part of combination antiretroviral therapy to treat HIV‑1 infection. The lopinavir component inhibits the viral protease, while ritonavir boosts lopinavir levels, together helping to suppress viral replication in both adult and pediatric patients.

Lopinavir binds to the active site of HIV‑1 protease, blocking the enzyme that cleaves viral polyproteins. This prevents the formation of mature, infectious virus particles. Ritonavir inhibits the CYP3A4 enzyme, slowing lopinavir metabolism and increasing its plasma concentration, which enhances the overall antiviral effect.

The dose is determined by the prescribing clinician based on current HIV treatment guidelines, the patient’s age, weight, renal and hepatic function, and any co‑administered medications. Dosage adjustments are made to achieve optimal viral suppression while minimizing adverse effects.

Safety data in pregnancy and lactation are limited. The drug may be used when the potential benefit to the mother outweighs possible risks to the fetus or infant. Clinicians should discuss individual risks and consider alternative regimens if appropriate.

Enquiries are submitted via the product page on gnhindia.com, where you specify the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lopinavir/ritonavir is a protease‑inhibitor based regimen, offering a high barrier to resistance and suitability for patients who have failed other classes. Compared with integrase inhibitors, it may have a higher incidence of metabolic side effects but remains a key component of many WHO‑recommended first‑line and second‑line regimens.

Store the product at room temperature, below 25 °C, in the original packaging. Protect it from moisture and direct sunlight to maintain potency throughout its shelf life.

The medication is taken orally, usually as a tablet, with or without food as directed by the prescriber. It is typically administered twice daily, but the exact schedule should follow the clinician’s instructions and the specific treatment protocol.

Serious risks include hepatotoxicity, severe allergic reactions such as Stevens‑Johnson syndrome, pancreatitis, and cardiac arrhythmias due to QT prolongation. Patients should be monitored regularly for liver function, lipid levels, and any signs of hypersensitivity.

Patients with known hypersensitivity to lopinavir, ritonavir, or any excipients in the formulation should avoid the product. Caution is also advised for individuals with severe liver impairment, uncontrolled cardiac disease, or those taking contraindicated strong CYP3A4 inducers.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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