Product image of Macmiror Complex 500 (Nystatin, Nifuratel) supplied by GNH India

Macmiror Complex 500

Active Ingredient:
Nystatin, Nifuratel
Origin:
EU

Macmiror Complex 500 (Nystatin, Nifuratel)

Nystatin and Nifuratel, the active ingredients in Macmiror Complex 500, are an antifungal/antibacterial combination presented as a vaginal formulation for local use. They treat vaginal fungal, bacterial and protozoal infections in adult women.
GNH India supplies Macmiror Complex 500 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Polichem S.A.

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Indications & Clinical Uses

  • Macmiror Complex 500 acts on the vaginal microbiome to treat common infections.
  • Vaginal candidiasis: reduces fungal load and relieves itching, discharge and irritation.
  • Bacterial vaginosis: eliminates anaerobic bacteria, restoring normal flora.
  • Trichomoniasis: eradicates the protozoan parasite, alleviating symptoms and preventing recurrence.

How It Works

  • Nystatin binds to ergosterol in fungal cell membranes, creating pores that increase permeability and cause cell death. Nifuratel interferes with bacterial DNA synthesis and exhibits activity against anaerobic bacteria and protozoa, disrupting their replication and leading to microbial eradication within the vaginal environment.

Side Effects

Common Side Effects

  • Vaginal irritation or burning sensation.
  • Itching or mild pruritus.
  • Increased vaginal discharge.
  • Local allergic reaction (redness, swelling).
  • Mild abdominal discomfort.
  • Unpleasant odor.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis).
  • Persistent vaginal ulceration.
  • Systemic fungal infection (rare).
  • Severe dermatitis or skin necrosis.
  • Significant swelling of the vulva.
  • Rare cases of hypersensitivity-induced fever.

Precautions & Warnings

  • Before using Macmiror Complex 500, consider the following precautions.
  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: discuss potential risks with a physician.
  • Allergy: avoid if known hypersensitivity to nystatin, nifuratel, or excipients.
  • Concurrent vaginal products: do not use other intravaginal medications simultaneously.
  • Immunocompromised patients: monitor closely for infection progression.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Macmiror Complex 500 may interact with other medicines as follows.

Major Interactions (Avoid)

  • Systemic antifungals: may increase systemic absorption of nystatin.
  • Broad‑spectrum antibiotics: can alter vaginal flora and reduce efficacy.
  • Immunosuppressants: heightened risk of infection.

Moderate Interactions (Monitor Closely)

  • Hormonal contraceptives: possible reduced effectiveness.
  • Topical steroids: may mask local irritation.
  • Other intravaginal medications: could affect absorption or increase irritation.

Frequently Asked Questions

Macmiror Complex 500 is indicated for the treatment of vaginal infections such as candidiasis, bacterial vaginosis, and trichomoniasis. It combines an antifungal and an antibacterial agent to target a broad range of pathogens that cause these common gynecological conditions.

Nystatin binds to ergosterol in fungal cell membranes, forming pores that disrupt membrane integrity and cause cell death. Nifuratel interferes with bacterial DNA synthesis and exhibits activity against anaerobic bacteria and protozoa, preventing their replication and leading to eradication of the infection.

The dosage regimen for Macmiror Complex 500 is determined by the prescribing clinician based on the specific infection, severity, and patient factors. Healthcare providers will specify the frequency and duration of intravaginal application appropriate for each case.

Safety data for Macmiror Complex 500 in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare professional before using this medication.

To order Macmiror Complex 500, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Macmiror Complex 500 combines an antifungal (nystatin) and an antibacterial/protozoal agent (nifuratel) in a single formulation, offering broader coverage than single‑agent products such as nystatin alone or metronidazole alone. This dual action can simplify therapy for mixed infections but may not be necessary for infections caused by a single pathogen.

Store Macmiror Complex 500 at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations to maintain its stability and effectiveness.

Macmiror Complex 500 is intended for intravaginal use. The prescribed amount is inserted into the vagina using the supplied applicator or as directed by a healthcare professional, typically once or twice daily for the duration specified by the prescriber.

The most serious risks include severe allergic reactions such as anaphylaxis, persistent vaginal ulceration, and rare systemic fungal infections. Patients should seek immediate medical attention if they experience symptoms like swelling of the vulva, difficulty breathing, or extensive ulceration.

Individuals with known hypersensitivity to nystatin, nifuratel, or any excipients in the formulation should avoid using Macmiror Complex 500. Additionally, patients with severe immunosuppression should use the product only under close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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