Macmiror Complex (Nystatin, Nifuratel)

Macmiror Complex, containing Nystatin and Nifuratel, is used to treat vaginal infections caused by fungi, bacteria, or protozoa.

• Vaginal candidiasis: eradicates Candida species and relieves itching and discharge.
• Bacterial vaginosis: reduces overgrowth of anaerobic bacteria and restores normal flora.
• Trichomoniasis: eliminates Trichomonas vaginalis parasites and improves symptoms.

• Nystatin binds to ergosterol in fungal cell membranes, creating pores that increase permeability and cause cell death. Nifuratel interferes with nucleic acid synthesis and metabolic pathways of bacteria and protozoa, inhibiting their growth and replication, resulting in broad‑spectrum antimicrobial activity within the vaginal environment.

Macmiror Complex may cause local adverse reactions, most of which are mild and transient.

Common Side Effects

• Vaginal irritation or burning sensation.
• Itching or mild discomfort.
• Unpleasant vaginal discharge or odor.
• Mild abdominal cramping.
• Local allergic skin reaction.
• Temporary increase in vaginal secretions.

Serious or Rare Side Effects

• Severe allergic reaction (anaphylaxis) with swelling, difficulty breathing.
• Persistent or worsening vaginal ulceration.
• Severe, persistent irritation or pain.
• Systemic hypersensitivity symptoms such as rash, fever, or joint pain.
• Rare cases of secondary infection.
• Significant swelling of the vulvar area.

Before using Macmiror Complex, consider the following safety measures.

• Pregnancy safety: Unknown; consult a healthcare professional before use.
• Breastfeeding safety: Unknown; discuss with a physician.
• Allergic reactions: Avoid if known hypersensitivity to Nystatin, Nifuratel, or formulation excipients.
• Concomitant vaginal products: Do not use other intravaginal medications unless advised.
• Medical supervision: Use only under prescription and follow medical guidance.
• Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Macmiror Complex may interact with other medications, requiring attention to avoid reduced efficacy or increased irritation.

Major Interactions (Avoid)

• Concurrent use with other intravaginal antifungal agents may increase local irritation.
• Simultaneous application of vaginal spermicides can diminish antimicrobial activity.

Moderate Interactions (Monitor Closely)

• Systemic azole antifungals may have additive antifungal effects; monitor for signs of toxicity.
• Use with systemic antibiotics may alter vaginal flora; observe for secondary infections.
• Co‑administration with hormonal contraceptives does not affect efficacy but monitor for local discomfort.
• Interaction with topical steroids may mask irritation signs; assess regularly.