Product image of Macmiror Complex (Nystatin, Nifuratel) supplied by GNH India

Macmiror Complex

Active Ingredient:
Nystatin, Nifuratel
Origin:
EU

Macmiror Complex (Nystatin, Nifuratel)

Nystatin, the active ingredient in Macmiror Complex, is an antifungal/antimicrobial presented as a vaginal formulation for vaginal use. It treats vulvovaginal candidiasis, bacterial vaginosis and trichomoniasis in women.
GNH India supplies Macmiror Complex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Polichem S.A.

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Indications & Clinical Uses

Macmiror Complex combines two agents that act against fungal, bacterial and protozoal pathogens causing vaginal infections.

  • Vulvovaginal candidiasis: reduces fungal load and relieves itching, burning and discharge.
  • Bacterial vaginosis: suppresses anaerobic bacterial overgrowth and restores normal flora.
  • Trichomoniasis: eliminates Trichomonas vaginalis, decreasing irritation and abnormal discharge.

How It Works

  • Nystatin binds to ergosterol in fungal cell membranes, creating pores that cause leakage of intracellular components and cell death. Nifuratel interferes with microbial nucleic acid synthesis and metabolic pathways, providing antibacterial and antiprotozoal activity that complements the antifungal effect, together delivering broad‑spectrum vaginal anti‑infective action.

Side Effects

Adverse reactions may occur with any vaginal anti‑infective preparation.

Common Side Effects

  • Local irritation or burning sensation.
  • Vaginal itching or mild rash.
  • Increased vaginal discharge of a different colour.
  • Mild abdominal discomfort.

Serious or Rare Side Effects

  • Allergic reaction with swelling of the face, lips or tongue.
  • Severe vaginal ulceration or necrosis.
  • Systemic hypersensitivity manifesting as fever or rash.
  • Rare hepatic dysfunction with elevated liver enzymes.

Precautions & Warnings

Use Macmiror Complex only under medical supervision and consider the following precautions.

  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: discuss potential risks with a clinician.
  • Known hypersensitivity: avoid if allergic to nystatin, nifuratel or excipients.
  • Concurrent vaginal products: do not use other medicated creams or douches simultaneously.
  • Underlying conditions: inform the prescriber of any chronic illnesses, especially liver disease.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and heat.

Avoid Interactions

Macmiror Complex may interact with other medicines; monitor as indicated.

Major Interactions (Avoid)

  • Systemic antifungals (e.g., amphotericin B) that could increase toxicity when combined.
  • Oral antibiotics that dramatically alter vaginal flora, potentially reducing efficacy.

Moderate Interactions (Monitor Closely)

  • Topical steroids applied to the vagina, which may mask local irritation.
  • Hormonal contraceptives, as altered flora could affect absorption.
  • Anticoagulants, if systemic absorption occurs, may affect clotting parameters.

Frequently Asked Questions

Macmiror Complex is indicated for the treatment of vulvovaginal candidiasis, bacterial vaginosis and trichomoniasis. It targets fungal, bacterial and protozoal pathogens that cause these common vaginal infections.

Nystatin binds to ergosterol in fungal cell membranes, forming pores that cause cell leakage and death. Nifuratel interferes with microbial nucleic acid synthesis and metabolic pathways, providing antibacterial and antiprotozoal activity that complements the antifungal effect.

The dosage regimen for Macmiror Complex is determined by the prescribing healthcare professional based on the specific infection, severity and patient characteristics. Patients should follow the prescriber’s instructions exactly.

Safety data for Macmiror Complex in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the product.

To request Macmiror Complex, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Macmiror Complex combines an antifungal (nystatin) with an antimicrobial (nifuratel), offering broader coverage than single‑agent products that target only fungi or bacteria. This dual mechanism can be advantageous when mixed infections are suspected, but choice of therapy should be guided by clinical assessment and microbiological testing.

Store Macmiror Complex at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct heat, and ensure the container is tightly closed when not in use.

Macmiror Complex is intended for vaginal administration. The prescribed dosage form is inserted into the vagina according to the prescriber’s directions, typically using an applicator or vaginal tablet, and the treatment course is completed as instructed.

Serious risks include allergic reactions such as facial swelling, severe vaginal ulceration, and rare systemic hypersensitivity that may present with fever or rash. Patients should seek immediate medical attention if any of these symptoms occur.

Macmiror Complex should be avoided by individuals with known hypersensitivity to nystatin, nifuratel or any excipients in the formulation. It is also contraindicated in patients for whom a vaginal anti‑infective is medically inappropriate, as determined by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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