Product image of Macmirorcomplex (Nystatin, Nifuratel) supplied by GNH India

Macmirorcomplex

Active Ingredient:
Nystatin, Nifuratel
Origin:
EU

Macmirorcomplex (Nystatin, Nifuratel)

Nystatin and Nifuratel, the active ingredients in Macmirorcomplex, are an antifungal and an antiprotozoal presented as a vaginal dosage form for local administration. The combination targets common vaginal infections, specifically treating candidiasis, bacterial vaginosis and trichomoniasis in adult female patients.

GNH India supplies Macmirorcomplex as a licensed, GDP‑compliant international pharmaceutical product, providing reliable bulk and packaged supplies to hospitals, pharmacies, transplant centres and oncology centres worldwide, adhering to EU quality standards and regulatory requirements. The company ensures timely shipment and comprehensive technical support.

Manufacturer / TM Owner

Polichem S.A.

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Indications & Clinical Uses

Macmirorcomplex combines Nystatin and Nifuratel to act on fungal, bacterial and protozoal pathways in the vagina.

  • Vaginal candidiasis: eradicates Candida species, relieving itching, discharge and irritation.
  • Bacterial vaginosis: reduces Gardnerella and other anaerobic bacteria, helping restore normal vaginal flora.
  • Trichomoniasis: eliminates Trichomonas vaginalis, alleviating malodorous discharge and discomfort.

How It Works

  • Nystatin binds to ergosterol in fungal cell membranes, creating pores that increase membrane permeability and lead to cell death. Nifuratel interferes with microbial metabolic pathways and DNA synthesis, providing broad‑spectrum activity against bacteria and protozoa, thereby complementing the antifungal effect of Nystatin.

Side Effects

Macmirorcomplex may cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Vaginal irritation or burning: mild discomfort at the application site.
  • Itching or pruritus: transient sensation of itchiness.
  • Abnormal vaginal discharge: temporary change in discharge consistency or color.
  • Vulvar erythema: mild redness of the external genitalia.
  • Mild gastrointestinal upset: occasional nausea or abdominal discomfort.
  • Local allergic reaction: limited rash or swelling.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic response requiring immediate medical attention.
  • Severe vaginal ulceration: extensive tissue damage or ulcer formation.
  • Systemic fungal infection: rare dissemination of fungal organisms.
  • Hepatotoxicity: abnormal liver function tests in susceptible individuals.

Precautions & Warnings

Before using Macmirorcomplex, consider the following precautions.

  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: discuss potential risks with a physician.
  • Known hypersensitivity: avoid if allergic to Nystatin, Nifuratel, or formulation excipients.
  • Concurrent vaginal products: do not use other intravaginal medications within two hours of application.
  • Complete therapy: finish the prescribed course even if symptoms improve.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Macmirorcomplex may interact with other medicines; monitor as indicated.

Major Interactions (Avoid)

  • Systemic azole antifungals: concurrent use may increase toxicity.
  • Intravaginal antiseptics or spermicides: may reduce therapeutic effectiveness.

Moderate Interactions (Monitor Closely)

  • Broad‑spectrum antibiotics: can alter vaginal flora and affect drug performance.
  • Topical corticosteroids: may mask local irritation or inflammation.
  • Immunosuppressive agents: heightened risk of opportunistic infections.

Frequently Asked Questions

Macmirorcomplex is a combination vaginal product containing Nystatin and Nifuratel. It is indicated for the treatment of vaginal candidiasis, bacterial vaginosis and trichomoniasis, providing antifungal, antibacterial and antiprotozoal activity in adult women.

Nystatin binds to ergosterol, a key component of fungal cell membranes. This binding creates pores that increase membrane permeability, leading to leakage of intracellular contents and ultimately causing fungal cell death.

Nifuratel interferes with microbial metabolism and DNA synthesis. By disrupting these essential processes, it exerts broad‑spectrum activity against a range of bacteria and protozoa, complementing the antifungal effect of Nystatin.

The dosage and duration of therapy are determined by the prescribing clinician based on the specific infection and patient characteristics. Patients should follow the prescriber’s instructions and complete the full course of treatment.

Safety data for Macmirorcomplex in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the product.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑agent products such as Nystatin alone or metronidazole, Macmirorcomplex offers a broader spectrum by combining an antifungal (Nystatin) with an antiprotozoal/antibacterial agent (Nifuratel). This dual action can simplify therapy for mixed infections, though individual patient factors and local resistance patterns should guide selection.

Store Macmirorcomplex at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Macmirorcomplex is applied intravaginally. The prescribed amount is inserted into the vagina using the supplied applicator or as directed by the healthcare professional, typically once or twice daily for the duration specified by the prescriber.

Serious adverse reactions, although rare, include severe allergic responses such as anaphylaxis, extensive vaginal ulceration, and systemic fungal infection. Patients should seek immediate medical attention if they experience symptoms like difficulty breathing, intense swelling, or persistent severe pain.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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