Product image of Macoil (Omega-3-Acid Ethyl Esters 90) supplied by GNH India

Macoil

Active Ingredient:
Omega-3-Acid Ethyl Esters 90
Origin:
EU

Macoil (Omega-3-Acid Ethyl Esters 90)

Omega-3-acid ethyl esters, the active ingredient in Macoil, is a omega-3 fatty acid presented as an oral formulation for oral use. It is used to help manage elevated triglyceride concentrations in adult patients as part of a lipid-lowering strategy.

GNH India supplies Macoil as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to European Union quality standards and provides regulatory documentation for cross-border procurement.

Manufacturer / TM Owner

Vian S.A.

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Indications & Clinical Uses

Macoil, an omega-3 fatty acid ethyl ester, is used to address disorders of lipid metabolism, particularly elevated triglyceride levels.

  • Hypertriglyceridemia: reduces plasma triglyceride concentrations as an adjunct to diet.
  • Familial hyperchylomicronemia: helps lower extremely high triglyceride levels in genetically predisposed individuals.
  • Cardiovascular risk reduction (adjunct): may be used alongside statin therapy to support overall lipid management.

How It Works

  • Omega-3-acid ethyl esters provide ethyl ester forms of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). After oral absorption, the esters are hydrolyzed to free EPA and DHA, which inhibit hepatic very-low-density lipoprotein (VLDL) synthesis and enhance β-oxidation of fatty acids. This results in decreased secretion of triglyceride‑rich lipoproteins and a net reduction of circulating triglyceride levels.

Side Effects

Oral omega-3 ethyl esters are generally well tolerated, but several adverse reactions have been reported.

Common Side Effects

  • Fishy aftertaste or belching.
  • Nausea or mild stomach upset.
  • Diarrhea or loose stools.
  • Abdominal discomfort or bloating.

Serious or Rare Side Effects

  • Acute pancreatitis.
  • Severe allergic reactions, including rash or angioedema.
  • Bleeding complications, especially when combined with anticoagulants.
  • Elevated liver enzymes (ALT/AST).

Precautions & Warnings

When prescribing or dispensing Macoil, consider the following precautions to ensure safe use.

  • Assess triglyceride levels: confirm indication before initiating therapy.
  • Monitor for bleeding: caution in patients on anticoagulants or with bleeding disorders.
  • Evaluate liver function: periodic testing recommended for patients with hepatic disease.
  • Pregnancy and lactation: use only if potential benefit outweighs risk, as safety data are limited.
  • Concomitant fish oil supplements: avoid duplicate dosing to reduce gastrointestinal irritation.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Omega-3 ethyl esters can affect the pharmacodynamics or pharmacokinetics of several medicines.

Major Interactions (Avoid)

  • Anticoagulants (warfarin, direct oral anticoagulants): increased bleeding risk.
  • High-dose vitamin E: additive anticoagulant effect.
  • Other omega-3 or fish-oil products: risk of excessive dosing and gastrointestinal upset.

Moderate Interactions (Monitor Closely)

  • Statins: potential for mild increase in muscle-related symptoms.
  • Antihypertensive agents: possible additive blood-pressure lowering effect.
  • Immunosuppressants (e.g., cyclosporine): may alter drug levels; monitor concentrations.

Frequently Asked Questions

Macoil contains omega-3-acid ethyl esters and is used as an adjunct to diet to help lower elevated plasma triglyceride concentrations in adults. It is commonly prescribed for hypertriglyceridemia and may be part of a broader lipid‑management plan that includes lifestyle changes and other lipid‑lowering therapies.

The ethyl ester forms of EPA and DHA are absorbed after oral intake and then hydrolyzed to their free fatty‑acid forms. These fatty acids inhibit hepatic VLDL synthesis, increase fatty‑acid β‑oxidation, and enhance clearance of triglyceride‑rich particles, leading to a reduction in circulating triglyceride levels.

The appropriate dose of Macoil is determined by the prescribing healthcare professional based on the individual’s triglyceride level, overall cardiovascular risk, and concomitant therapies. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for omega-3-acid ethyl esters in pregnancy and lactation are limited. Use is generally reserved for situations where the potential benefit to the mother outweighs any possible risk to the fetus or infant, and only under the direction of a qualified healthcare provider.

To request Macoil, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Macoil provides omega-3 in the ethyl‑ester form, which may have higher concentration of EPA/DHA per capsule compared with standard fish‑oil triglyceride preparations. Ethyl esters require hydrolysis before absorption, which can be slightly slower, but clinical studies show comparable triglyceride‑lowering efficacy when dosed appropriately.

Macoil should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the container tightly closed and out of reach of children. No refrigeration is required for this oral formulation.

Macoil is taken orally, usually with a meal to improve absorption and reduce gastrointestinal discomfort. The exact frequency and number of capsules are set by the prescriber. Swallow the capsules whole with water; do not crush or chew them.

The most serious adverse events associated with omega-3 ethyl esters include acute pancreatitis, severe allergic reactions (such as rash, angioedema, or anaphylaxis), and bleeding complications, especially when combined with anticoagulant or antiplatelet drugs. Patients should seek immediate medical attention if they experience symptoms such as severe abdominal pain, unexplained bruising, or signs of an allergic reaction.

Macoil should be avoided in individuals with known hypersensitivity to omega-3 fatty acids or any of the product’s excipients. Patients with active bleeding disorders, uncontrolled hypertension, or severe liver disease should consult their physician before starting therapy. It is also contraindicated in those taking high‑dose anticoagulants without close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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