Product image of Macro-Albumon (Human Albumin As Macroaggregates) supplied by GNH India

Macro-Albumon

Active Ingredient:
Human Albumin As Macroaggregates
Origin:
EU

Macro-Albumon (Human Albumin As Macroaggregates)

Human Albumin, the active ingredient in Macro-Albumon, is a biologic presented as a sterile solution for intravenous use. It is employed to expand plasma volume in patients with acute fluid loss, such as during surgery, trauma, or severe burns.

GNH India supplies Macro-Albumon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Medi-Radiopharma Kft.

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Indications & Clinical Uses

Macro-Albumon, a human albumin macroaggregate, is used to restore intravascular volume in conditions associated with plasma loss.

  • Hypovolemia: increases circulating plasma volume to improve tissue perfusion.
  • Major surgery: maintains hemodynamic stability during operative blood loss.
  • Severe burns: supports fluid resuscitation and reduces edema.
  • Massive hemorrhage: rapidly expands intravascular volume to stabilize blood pressure.

How It Works

  • Human albumin macroaggregates act as colloidal plasma expanders. After intravenous infusion, they remain largely within the vascular compartment, raising oncotic pressure and drawing water from the interstitial space into the circulation. This expands plasma volume, improves cardiac preload, and enhances tissue oxygen delivery while also binding endogenous substances such as fatty acids and drugs.

Side Effects

Common Side Effects

  • Fever or chills
  • Mild hypotension
  • Headache
  • Nausea or vomiting
  • Localized rash at infusion site
  • Transient dizziness

Serious or Rare Side Effects

  • Anaphylactic reaction
  • Severe volume overload leading to pulmonary edema
  • Hemolysis
  • Acute renal failure
  • Infection transmission risk
  • Thromboembolic events

Precautions & Warnings

Macro-Albumon should be administered under careful clinical monitoring.

  • Assess volume status: evaluate fluid balance before infusion.
  • Monitor vital signs: watch for hypotension or hypertension during administration.
  • Use cautiously in heart failure: risk of volume overload.
  • Avoid in known albumin allergy: discontinue if hypersensitivity occurs.
  • Observe for infection signs: ensure product sterility.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Potential drug interactions require clinical awareness.

Major Interactions (Avoid)

  • Concurrent high‑dose diuretics: may precipitate severe hypotension.
  • Other volume expanders (e.g., hydroxyethyl starch): increase risk of overload.
  • Anticoagulants: may enhance bleeding risk due to dilutional effects.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: monitor blood pressure for additive hypotensive effect.
  • Vasopressors: adjust dosing as albumin may alter vascular responsiveness.
  • Blood products: coordinate timing to avoid volume excess.
  • Other colloids: assess cumulative oncotic load.

Frequently Asked Questions

Macro-Albumon is a sterile intravenous solution of human albumin macroaggregates used as a plasma volume expander. It helps restore circulating blood volume in patients experiencing acute fluid loss due to surgery, trauma, burns, or massive hemorrhage, supporting hemodynamic stability.

Human albumin in Macro-Albumon increases oncotic pressure within the vascular compartment. By retaining water inside blood vessels, it expands plasma volume, improves cardiac preload, and enhances tissue perfusion. Albumin also binds various endogenous substances, contributing to its stabilizing effect on circulatory dynamics.

The dosage of Macro-Albumon is individualized. The prescribing clinician determines the volume and rate of infusion based on the patient’s clinical condition, degree of fluid loss, and response to therapy. No fixed regimen is provided in public information.

Safety data for Macro-Albumon in pregnancy or lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To order Macro-Albumon, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required), and import documentation.

Compared with synthetic colloids such as hydroxyethyl starch, Macro-Albumon (human albumin) is a natural protein that offers oncotic support with a lower risk of renal dysfunction. Crystalloid solutions provide less oncotic effect and require larger volumes, while albumin offers efficient plasma expansion with fewer electrolyte disturbances.

Macro-Albumon must be stored at 2‑8 °C, protected from light, and should never be frozen or shaken. Keep the product in its original packaging until use to maintain sterility and stability.

Macro-Albumon is administered intravenously by slow infusion, typically through a dedicated line. The infusion rate is adjusted according to the patient’s hemodynamic response and clinical guidelines, with continuous monitoring of vital signs throughout the procedure.

Serious risks include anaphylactic reactions, severe volume overload leading to pulmonary edema, hemolysis, and rare infections transmitted through the biologic product. Prompt recognition and management of these events are essential.

Macro-Albumon is contraindicated in patients with known hypersensitivity to human albumin or any component of the formulation. Caution is advised for individuals with uncontrolled heart failure, severe renal impairment, or active infection, where volume expansion may pose additional risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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