Product image of Macrocyclolux (Gadoteric Acid) supplied by GNH India

Macrocyclolux

Active Ingredient:
Gadoteric Acid
Origin:
EU

Macrocyclolux (Gadoteric Acid)

Gadoteric acid, the active ingredient in Macrocyclolux, is a gadolinium‑based contrast agent presented as an injection solution for intravenous use. It enhances magnetic resonance imaging by increasing signal intensity, aiding diagnosis of brain, spine, liver and vascular conditions in patients undergoing MRI examinations.

GNH India supplies Macrocyclolux as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, clinics and imaging centres worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand through reliable cold‑chain logistics.

Manufacturer / TM Owner

Sanochemia Pharmazeutika Gmbh

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Indications & Clinical Uses

  • Macrocyclolux, a gadolinium‑based contrast agent, is employed in magnetic resonance imaging to improve visualization of specific anatomical regions.
  • Brain MRI: provides enhanced signal intensity that facilitates detection of intracranial lesions and vascular abnormalities.
  • Spine MRI: improves contrast of spinal cord, vertebral bodies and surrounding soft tissues for better assessment of pathology.
  • Liver MRI: enables clearer delineation of focal liver lesions and vascular structures during hepatic imaging.
  • MRI angiography: enhances vascular delineation, allowing detailed evaluation of arterial and venous anatomy.

How It Works

  • Macrocyclolux contains gadoteric acid, a chelated gadolinium complex that acts as a paramagnetic agent. After intravenous administration, the gadolinium ion shortens the T1 relaxation time of nearby water protons, resulting in increased signal intensity on T1‑weighted MRI sequences. This property improves the contrast between vascular and tissue structures, facilitating more accurate anatomical and pathological assessment.

Side Effects

Adverse reactions to Macrocyclolux may vary in frequency and severity.

Common Side Effects

  • Nausea
  • Headache
  • Injection site warmth or flushing
  • Metallic taste in the mouth

Serious or Rare Side Effects

  • Nephrogenic systemic fibrosis (NSF)
  • Severe allergic reaction or anaphylaxis
  • Cardiovascular collapse or severe hypotension

Precautions & Warnings

  • Prior to administration, several safety considerations should be observed.
  • Renal function assessment: evaluate kidney function before administration.
  • Hydration status: ensure adequate patient hydration to reduce renal risk.
  • Prior contrast reactions: review history of hypersensitivity to gadolinium agents.
  • Pregnancy: use only if clearly needed, as safety data are limited.
  • Concomitant nephrotoxic drugs: avoid or monitor closely.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Macrocyclolux may interact with other agents, requiring careful management.

Major Interactions (Avoid)

  • Concurrent use of other gadolinium‑based contrast agents: cumulative gadolinium exposure may increase toxicity risk.
  • Ferumoxytol (iron oxide nanoparticle): can cause diagnostic interference and potential adverse reactions.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may affect renal clearance of gadolinium, requiring monitoring of kidney function.
  • ACE inhibitors or ARBs: may influence renal perfusion; monitor renal parameters during and after administration.

Frequently Asked Questions

Macrocyclolux is a gadolinium‑based contrast medium used during magnetic resonance imaging. It improves the visibility of structures in brain, spine, liver and vascular studies, helping radiologists detect lesions, assess anatomy and make more accurate diagnostic interpretations.

Gadoteric acid is a chelated gadolinium complex that acts as a paramagnetic agent. When injected, it shortens the T1 relaxation time of nearby water protons, producing a brighter signal on T1‑weighted MRI images and thereby enhancing the contrast between tissues and blood vessels.

The dose of Macrocyclolux is determined by the prescribing physician based on the patient’s weight, the specific MRI protocol and the anatomical region being examined. Dosing guidelines are provided in the product labeling and should be followed by qualified healthcare professionals.

Safety data for gadoteric acid in pregnant or lactating women are limited. The product should only be used during pregnancy or breastfeeding when clearly needed and after a risk‑benefit assessment by the healthcare provider.

To order Macrocyclolux, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Macrocyclolux offers comparable relaxivity and image enhancement to other macrocyclic gadolinium agents. Its chelate provides high kinetic stability, which may reduce the risk of gadolinium release. Clinical choice often depends on specific imaging protocols, safety considerations and institutional preferences.

Macrocyclolux must be stored refrigerated at 2‑8 °C. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking the solution. Before use, inspect the product for any particulate matter or discoloration.

Macrocyclolux is administered as an intravenous injection, typically as a rapid bolus immediately before the MRI scan. The exact injection rate and volume are defined by the imaging protocol and the prescribing physician.

The most serious risks include nephrogenic systemic fibrosis in patients with severe renal impairment and severe allergic reactions such as anaphylaxis. Cardiovascular collapse or severe hypotension can also occur, requiring immediate medical attention.

Macrocyclolux should be avoided in patients with known hypersensitivity to gadolinium‑based agents, those with severe renal dysfunction (e.g., GFR < 30 mL/min/1.73 m²), and in individuals where the benefit does not outweigh the potential risk, such as certain pregnant women.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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