Product image of Macrogol - 1 A Pharma (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350) supplied by GNH India

Macrogol - 1 A Pharma

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350
Origin:
EU

Macrogol - 1 A Pharma (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Macrogol 3350, the active ingredient in Macrogol - 1 A Pharma, is an osmotic laxative presented as an oral powder for oral use. Combined with sodium hydrogen carbonate, potassium chloride and sodium chloride, it draws water into the intestinal lumen to soften stool and facilitate bowel cleansing in adults and children.

GNH India supplies Macrogol - 1 A Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product meets EU quality standards and is manufactured under GMP conditions.

Manufacturer / TM Owner

1 A Pharma Gmbh

1
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Indications & Clinical Uses

Macrogol 3350 is an osmotic laxative used to manage conditions involving impaired bowel transit.

  • Constipation: softens stool and promotes regular bowel movements in patients with functional constipation.
  • Bowel preparation for colonoscopy: clears the intestinal tract to allow clear visualization during endoscopic procedures.
  • Fecal impaction: facilitates evacuation of hardened stool in cases of impaction.

How It Works

  • Macrogol 3350 acts as a high‑molecular‑weight polyethylene glycol that is poorly absorbed in the gastrointestinal tract. It retains water in the lumen by creating an osmotic gradient, increasing stool volume and softness. The accompanying electrolytes (sodium hydrogen carbonate, potassium chloride, sodium chloride) help maintain fluid and electrolyte balance during the laxative effect.

Side Effects

Macrogol 3350 may be associated with a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Abdominal bloating: sensation of fullness or swelling in the abdomen.
  • Nausea: mild to moderate feeling of queasiness.
  • Flatulence: increased intestinal gas.
  • Diarrhea: loose stools occurring more frequently.
  • Abdominal pain: cramping or discomfort.
  • Headache: mild headache during treatment.

Serious or Rare Side Effects

  • Severe dehydration: excessive fluid loss requiring medical attention.
  • Electrolyte imbalance: abnormal sodium or potassium levels.
  • Allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Severe abdominal pain: persistent or worsening pain.
  • Rectal bleeding: blood in stool indicating mucosal injury.

Precautions & Warnings

When prescribing Macrogol 3350, consider the following precautions:

  • Avoid use in complete bowel obstruction: risk of perforation and worsening obstruction.
  • Caution in renal impairment: monitor electrolyte balance due to sodium and potassium content.
  • Use carefully in patients with inflammatory bowel disease flare: may exacerbate symptoms.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Macrogol 3350 can interact with other medications; monitor patients accordingly.

Major Interactions (Avoid)

  • Concurrent use of other osmotic laxatives: may cause severe dehydration and electrolyte imbalance.
  • High-dose diuretics: increase risk of electrolyte disturbances.
  • Intravenous electrolyte solutions: additive sodium and potassium load may lead to hypernatremia or hyperkalemia.

Moderate Interactions (Monitor Closely)

  • Antacids containing sodium bicarbonate: may augment sodium load.
  • NSAIDs: may increase risk of gastrointestinal irritation.
  • Antibiotics altering gut flora: could affect laxative efficacy.

Frequently Asked Questions

Macrogol - 1 A Pharma is an oral powder containing macrogol 3350 and electrolytes that is used to relieve constipation, to prepare the bowel before procedures such as colonoscopy, and to assist in the evacuation of fecal impaction.

Macrogol 3350 is a high‑molecular‑weight polyethylene glycol that is not absorbed in the gut. It creates an osmotic gradient that draws water into the intestinal lumen, softening stool and increasing its volume, which promotes bowel movements.

The dose is individualized by the prescribing healthcare professional based on the patient’s age, weight, condition being treated, and response to therapy. The prescriber determines the appropriate amount and duration of treatment.

Safety in pregnancy and lactation has not been fully established. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and after consultation with a qualified healthcare provider.

Enquiries can be submitted on the product page at gnhindia.com by specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with stimulant laxatives, macrogol 3350 works by osmotic water retention rather than stimulating intestinal muscle activity, resulting in a gentler, more predictable effect and a lower incidence of cramping. It is also more suitable for bowel preparation because it does not cause significant electrolyte loss when used as directed.

Store the product below 25 °C in a dry place. Keep it in the original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

The powder is intended for oral use. It is typically dissolved in a specified volume of water or clear fluid, mixed thoroughly, and consumed as directed by the prescriber. The solution should be taken with adequate fluid to support the osmotic effect.

Serious risks include severe dehydration, significant electrolyte disturbances (such as hypernatremia or hyperkalemia), and rare allergic reactions that may present with rash, swelling, or breathing difficulties. Prompt medical attention is required if any of these occur.

Patients with a known complete bowel obstruction, perforated gastrointestinal tract, severe renal impairment, or active inflammatory bowel disease flare should avoid using this product unless specifically advised by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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