Product image of Macrogol 4000 Recordati (Macrogol 4000) supplied by GNH India

Macrogol 4000 Recordati

Active Ingredient:
Macrogol 4000
Origin:
EU

Macrogol 4000 Recordati (Macrogol 4000)

Macrogol 4000, the active ingredient in Macrogol 4000 Recordati, is an osmotic laxative presented as an oral powder for solution for oral use. It softens stool and promotes bowel movements in adults and children with constipation or requiring bowel cleansing.
GNH India supplies Macrogol 4000 Recordati as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Casen Recordati, S.L.

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Indications & Clinical Uses

Macrogol 4000 is an osmotic laxative used to manage conditions involving reduced bowel motility.

  • Constipation: softens stool and facilitates regular bowel movements in adults and children.
  • Chronic idiopathic constipation: provides long‑term relief of persistent constipation symptoms.
  • Bowel preparation for diagnostic procedures: clears the colon before colonoscopy or radiologic imaging.

How It Works

  • Macrogol 4000 is a high‑molecular‑weight polyethylene glycol that is minimally absorbed from the gastrointestinal tract. It creates an osmotic gradient that retains water within the intestinal lumen, increasing stool water content and volume, which stimulates peristalsis and accelerates colonic transit.

Side Effects

Macrogol 4000 may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Abdominal bloating: sensation of fullness or swelling in the abdomen.
  • Flatulence: increased intestinal gas.
  • Nausea: mild feeling of queasiness.
  • Abdominal cramps: intermittent cramping discomfort.
  • Diarrhea: loose stools, especially with higher doses.
  • Headache: mild to moderate head pain.

Serious or Rare Side Effects

  • Severe electrolyte imbalance: significant changes in sodium or potassium levels.
  • Allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Severe abdominal pain: intense, persistent pain.
  • Rectal bleeding: blood in stool indicating mucosal injury.
  • Dehydration: excessive fluid loss leading to dizziness or low blood pressure.
  • Acute renal failure: sudden loss of kidney function in susceptible individuals.

Precautions & Warnings

When prescribing or using Macrogol 4000, several safety considerations should be observed.

  • Assess renal function: avoid or adjust use in severe renal impairment.
  • Monitor electrolytes: watch for hyponatremia or other electrolyte disturbances.
  • Exclude bowel obstruction: do not use in patients with mechanical blockage of the intestine.
  • Use cautiously in the elderly: increased susceptibility to dehydration.
  • Pregnancy and lactation: consult a prescriber; limited safety data are available.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Macrogol 4000 can interact with other medications that affect fluid balance or gastrointestinal motility.

Major Interactions (Avoid)

  • Concurrent osmotic laxatives: risk of severe diarrhea and electrolyte loss.
  • Diuretics: may exacerbate dehydration and electrolyte disturbances.
  • Mineral oil: can reduce the efficacy of Macrogol 4000.

Moderate Interactions (Monitor Closely)

  • Anticholinergic agents: may diminish the laxative effect.
  • Opioid analgesics: can counteract bowel‑stimulating action.
  • Magnesium‑containing antacids: additive osmotic effect may increase fluid loss.

Frequently Asked Questions

Macrogol 4000 Recordati is an oral osmotic laxative indicated for the relief of occasional constipation, the management of chronic idiopathic constipation, and as a bowel‑cleansing agent before diagnostic procedures such as colonoscopy.

The active ingredient, macrogol 4000 (polyethylene glycol 4000), is a high‑molecular‑weight polymer that is not absorbed. It retains water in the intestinal lumen by creating an osmotic gradient, increasing stool water content and volume, which stimulates peristalsis and speeds up colonic transit.

The prescribed dose is individualized by the treating clinician based on the patient’s age, severity of constipation, and response to therapy. Typical adult regimens start with a measured amount of powder dissolved in water, but the exact quantity and frequency should follow the prescriber’s instructions.

Safety data in pregnancy and lactation are limited. The product should be used only if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified health‑care professional.

Enquiries are submitted via the product page on gnhindia.com, where you specify the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Compared with stimulant laxatives such as bisacodyl, macrogol 4000 works by osmotic water retention rather than stimulating intestinal nerves, resulting in softer stools with a lower risk of cramping. Lactulose also acts osmotically but may produce more gas. Macrogol 4000 is generally better tolerated for long‑term use.

Store the product at ambient temperature, below 25 °C, in its original packaging. Protect it from moisture and direct sunlight. Keep the container tightly closed to maintain powder integrity and prevent contamination.

The powder is dissolved in a measured volume of water, typically 150–250 ml, and consumed orally. It can be taken with or without food, but patients should follow the specific preparation instructions provided by the prescriber or pharmacist.

Serious adverse events include severe dehydration, electrolyte imbalances (especially hyponatremia), allergic reactions ranging from rash to anaphylaxis, and, in rare cases, acute renal failure. Patients should seek medical attention if they experience persistent diarrhea, dizziness, or signs of an allergic response.

Individuals with known hypersensitivity to macrogol or polyethylene glycol, those with mechanical bowel obstruction, severe renal impairment, or uncontrolled electrolyte disorders should avoid using this product. A health‑care professional should evaluate suitability before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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