Macrogol Compound (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Macrogol Compound is used as an osmotic agent to manage conditions requiring bowel cleansing or laxation.

• Constipation: softens stool and promotes regular bowel movements in patients with functional constipation.
• Bowel preparation for colonoscopy: provides thorough intestinal cleansing to improve visualization during endoscopic procedures.
• Irritable bowel syndrome with constipation (IBS‑C): helps alleviate constipation‑dominant symptoms and improve patient comfort.

• Macrogol 3350 is a high‑molecular‑weight polyethylene glycol that is poorly absorbed from the gastrointestinal tract. It retains water in the intestinal lumen by osmosis, increasing stool volume and softness, which stimulates peristalsis and facilitates bowel evacuation without significant electrolyte shifts.

Macrogol Compound may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Abdominal bloating: mild distension of the abdomen.
• Nausea: feeling of queasiness.
• Flatulence: increased intestinal gas.
• Diarrhea: loose stools occurring with higher doses.
• Cramping: intermittent abdominal pain.
• Headache: mild to moderate headache.

Serious or Rare Side Effects

• Electrolyte imbalance: rare disturbances in sodium or potassium levels.
• Severe dehydration: excessive fluid loss leading to low blood volume.
• Allergic reaction: rash, itching, or swelling.
• Persistent abdominal pain: ongoing severe discomfort.
• Syncope: fainting episodes.
• Severe abdominal pain: intense, localized pain requiring medical attention.

Before using Macrogol Compound, consider the following safety measures.

• Assess renal function: ensure adequate kidney function to handle fluid shifts.
• Review electrolyte status: monitor sodium and potassium levels in patients at risk.
• Contraindications: avoid in patients with intestinal obstruction or perforation.
• Pregnancy and lactation: use only if clearly needed and prescribed by a healthcare professional.
• Pediatric use: dosage and safety should be determined by a pediatric specialist.
• Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Macrogol Compound may interact with other medications, affecting absorption or electrolyte balance.

Major Interactions (Avoid)

• Digoxin: increased risk of toxicity due to altered electrolyte levels.
• Lithium: reduced lithium clearance may lead to toxicity.
• Antacids containing magnesium or aluminum: may decrease the laxative effect.

Moderate Interactions (Monitor Closely)

• Oral antibiotics: potential reduction in absorption.
• Thyroid hormone replacement: monitor thyroid function tests.
• Diuretics: watch for additive electrolyte disturbances.