Product image of Macrogol Eg (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350) supplied by GNH India

Macrogol Eg

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350
Origin:
EU

Macrogol Eg (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Macrogol 3350, the active ingredient in Macrogol Eg, is an osmotic laxative presented as a powder for oral solution for oral use. It treats constipation and prepares the bowel for diagnostic procedures in adults and children.

GNH India supplies Macrogol Eg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Eg S.P.A.

1
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Indications & Clinical Uses

  • Macrogol Eg is an osmotic laxative used to manage conditions affecting bowel function.
  • Constipation: softens stool and promotes regular bowel movements by retaining water in the intestinal lumen.
  • Bowel preparation for colonoscopy: cleanses the colon to improve visibility during endoscopic procedures.
  • Irritable bowel syndrome with constipation: helps alleviate constipation-predominant symptoms and improve stool frequency.

How It Works

  • Macrogol 3350 is a high‑molecular‑weight polyethylene glycol that is poorly absorbed in the gastrointestinal tract. It creates an osmotic gradient that draws water into the intestinal lumen, increasing stool volume and softness. The accompanying electrolytes (sodium, potassium, chloride) help maintain fluid and electrolyte balance while facilitating bowel transit.

Side Effects

Macrogol Eg may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Abdominal bloating or distension
  • Nausea or mild vomiting
  • Flatulence or gas
  • Diarrhea or loose stools
  • Abdominal cramps or discomfort
  • Increased thirst

Serious or Rare Side Effects

  • Severe electrolyte imbalance (e.g., hyponatremia, hypokalemia)
  • Marked dehydration requiring medical attention
  • Allergic reactions such as rash, itching, or swelling
  • Severe abdominal pain or intestinal perforation
  • Rectal bleeding or severe gastrointestinal hemorrhage

Precautions & Warnings

  • Before using Macrogol Eg, consider the following safety measures.
  • Assess renal function: ensure adequate kidney function to handle fluid shifts.
  • Monitor electrolyte status: check serum electrolytes in patients at risk of imbalance.
  • Avoid in bowel obstruction: contraindicated when mechanical blockage is present.
  • Hypersensitivity caution: discontinue if allergic reactions occur.
  • Pediatric dosing: adjust dose carefully under medical supervision.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Macrogol Eg can interact with other medications, influencing safety or efficacy.

Major Interactions (Avoid)

  • Concomitant osmotic laxatives: risk of severe dehydration and electrolyte loss.
  • Loop diuretics: may exacerbate electrolyte disturbances.
  • Anticholinergic agents: can reduce the laxative effect.

Moderate Interactions (Monitor Closely)

  • NSAIDs: potential for renal impairment when combined.
  • ACE inhibitors: monitor potassium levels due to additive effects.
  • Oral rehydration solutions: may alter intended electrolyte balance.

Frequently Asked Questions

Macrogol Eg is an oral osmotic laxative used to relieve constipation and to clean the bowel before diagnostic procedures such as colonoscopy. It works by drawing water into the intestines, softening stool and promoting regular bowel movements.

Macrogol 3350 is a large polyethylene glycol molecule that is not absorbed in the gut. It creates an osmotic gradient that pulls water from the surrounding tissues into the intestinal lumen, increasing stool volume and softness while the added electrolytes help maintain fluid balance.

The dose of Macrogol Eg is individualized by the prescribing healthcare professional based on the patient’s age, condition, and response. Patients should follow the prescriber’s instructions and not adjust the amount without medical guidance.

Safety data for Macrogol Eg in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order Macrogol Eg, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with stimulant laxatives, Macrogol Eg works by osmotic action rather than stimulating intestinal muscles, which often results in a gentler, more predictable effect and fewer cramping side effects. It also includes electrolytes, reducing the risk of fluid imbalance seen with some other osmotic agents.

Macrogol Eg should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, excessive heat and direct sunlight to maintain its stability and effectiveness.

Macrogol Eg is supplied as a powder that is dissolved in water to create an oral solution. The patient drinks the prepared solution as directed by the prescriber, usually in divided doses throughout the day, while maintaining adequate fluid intake.

Serious risks include severe electrolyte disturbances such as hyponatremia or hypokalemia, marked dehydration, allergic reactions, and, rarely, intestinal perforation or severe abdominal pain. Patients should seek immediate medical attention if they experience any of these symptoms.

Macrogol Eg should not be used by individuals with known hypersensitivity to any of its components, those with intestinal obstruction, severe renal impairment, or uncontrolled electrolyte abnormalities. It is also contraindicated in patients with acute abdominal conditions until evaluated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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