Macrogol + Electrolytes (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Macrogol + Electrolytes is an osmotic laxative that works within the gastrointestinal tract to manage conditions requiring increased stool water content and bowel cleansing.

• Constipation: softens stool and increases volume to promote regular bowel movements.
• Bowel preparation for colonoscopy: clears intestinal contents to enable clear endoscopic visualization.
• Pre‑operative bowel cleansing: prepares the colon for surgical or diagnostic interventions by removing residual fecal matter.

• Macrogol 3350 creates an osmotic gradient in the intestinal lumen, drawing water into the bowel and increasing stool bulk. The accompanying electrolytes (sodium hydrogen carbonate, potassium chloride, sodium chloride) help maintain fluid and electrolyte balance, preventing excessive shifts while the increased water content facilitates easier passage of stool.

Macrogol + Electrolytes may cause several adverse reactions, most of which are mild and transient.

Common Side Effects

• Abdominal bloating: feeling of fullness or swelling in the abdomen.
• Nausea: mild sensation of wanting to vomit.
• Flatulence: increased intestinal gas.
• Abdominal cramps: intermittent painful contractions.
• Thirst: increased desire to drink fluids.

Serious or Rare Side Effects

• Severe dehydration: marked loss of body water requiring medical attention.
• Electrolyte disturbances: significant shifts in sodium or potassium levels.
• Allergic reaction: rash, itching, swelling, or difficulty breathing.
• Severe abdominal pain: persistent, intense pain.
• Rectal bleeding: presence of blood in stool.

Before using Macrogol + Electrolytes, consider the following safety measures.

• Renal function assessment: evaluate kidney health to avoid fluid overload.
• Electrolyte monitoring: check serum electrolytes, especially in patients with cardiac or renal disease.
• Bowel obstruction caution: avoid use if there is known mechanical blockage.
• Dose adjustment in elderly: start with lower amounts due to altered fluid balance.
• Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Macrogol + Electrolytes can interact with other medications that affect fluid or electrolyte balance.

Major Interactions (Avoid)

• Other osmotic laxatives: combined use may cause severe dehydration.
• Loop diuretics: increased risk of electrolyte imbalance.
• Lithium therapy: altered lithium serum concentrations.

Moderate Interactions (Monitor Closely)

• Antacids containing magnesium: may reduce laxative effectiveness.
• NSAIDs: potential impact on renal function when combined.
• ACE inhibitors: possible additive effect on potassium levels.