Macrogol + Electrolytes Ab (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Macrogol 3350 with electrolytes is an osmotic laxative that works within the gastrointestinal tract to manage conditions related to impaired bowel motility.

• Constipation: softens stool and promotes regular bowel movements in patients with functional constipation.
• Bowel preparation: clears the colon before colonoscopy, sigmoidoscopy or other diagnostic procedures.
• Fecal impaction: helps to break down hardened stool in cases of impaction.

• Macrogol 3350 with electrolytes acts as an osmotic agent that retains water in the intestinal lumen by creating a high‑molecular‑weight, non‑absorbable solution. The increased intraluminal water content softens the fecal mass and expands the stool volume, stimulating peristalsis and facilitating the passage of bowel contents without being metabolized or absorbed systemically.

Common Side Effects

• Abdominal bloating: sensation of fullness or swelling in the abdomen.
• Flatulence: increased intestinal gas leading to discomfort.
• Nausea: mild feeling of queasiness.
• Mild abdominal cramps: transient cramping sensations.
• Diarrhea: loose stools occurring if the dose is high.
• Electrolyte imbalance: mild changes in serum sodium or potassium levels.

Serious or Rare Side Effects

• Severe dehydration: marked loss of body fluids requiring medical attention.
• Severe electrolyte disturbances: significant hyponatremia or hyperkalemia.
• Allergic reactions: rash, itching, or swelling of the face, lips, or tongue.
• Severe abdominal pain: persistent or worsening pain.
• Blood in stool: presence of visible blood indicating possible mucosal injury.
• Acute renal impairment: sudden decline in kidney function in susceptible individuals.

Before initiating therapy, consider the following precautions:

• Renal function assessment: evaluate kidney status, especially in patients with chronic kidney disease.
• Electrolyte monitoring: check serum sodium and potassium levels during prolonged use.
• Cardiac conditions: use cautiously in patients with heart failure or hypertension.
• Bowel obstruction: avoid in individuals with known mechanical obstruction.
• Duration of use: limit to the shortest period necessary to achieve the therapeutic goal.
• Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Macrogol + Electrolytes Ab may interact with other medicines as follows:

Major Interactions (Avoid)

• Other osmotic laxatives: concurrent use can cause excessive fluid loss and electrolyte imbalance.
• Mineral oil: combined use may increase the risk of intestinal blockage.
• Loop diuretics: may exacerbate electrolyte disturbances, especially hypokalemia.

Moderate Interactions (Monitor Closely)

• Antacids: may alter the absorption of concomitant oral medications.
• ACE inhibitors: monitor potassium levels due to additive effects.
• NSAIDs: watch for potential renal function changes when used together.