Product image of Macrogol En Elektrolyten (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350) supplied by GNH India

Macrogol En Elektrolyten

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350
Origin:
EU

Macrogol En Elektrolyten (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Macrogol 3350, the active ingredient in Macrogol En Elektrolyten, is an osmotic laxative presented as a powder for oral use. Combined with sodium hydrogen carbonate, potassium chloride and sodium chloride, it draws water into the intestinal lumen to soften stool and facilitate bowel movements in adults and children with constipation or requiring bowel preparation.

GNH India supplies Macrogol En Elektrolyten as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance for global distribution.

Manufacturer / TM Owner

Aurobindo Pharma B.V.

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Indications & Clinical Uses

Macrogol En Elektrolyten is used to manage conditions related to constipation and bowel cleansing.

  • Chronic constipation: softens stool and promotes regular bowel movements in patients with functional constipation.
  • Faecal impaction: facilitates evacuation of hardened stool in cases of impaction.
  • Bowel preparation for diagnostic procedures: clears the intestinal tract before colonoscopy or imaging studies.
  • Irritable bowel syndrome with constipation: provides symptomatic relief of infrequent bowel movements.

How It Works

  • Macrogol 3350 is a high‑molecular‑weight polyethylene glycol that is poorly absorbed from the gastrointestinal tract. It exerts an osmotic effect by retaining water within the intestinal lumen, increasing stool volume and softness. The accompanying electrolytes (sodium hydrogen carbonate, potassium chloride, sodium chloride) maintain electrolyte balance while the osmotic load promotes peristalsis, leading to easier passage of feces.

Side Effects

Macrogol En Elektrolyten may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Abdominal bloating or distension
  • Flatulence or gas
  • Nausea or mild stomach upset
  • Diarrhea or loose stools
  • Headache
  • Mild abdominal cramping

Serious or Rare Side Effects

  • Electrolyte imbalance (e.g., hypernatremia, hypokalemia)
  • Severe dehydration
  • Allergic reactions such as rash, itching, or swelling
  • Intestinal obstruction or perforation in predisposed patients
  • Persistent severe abdominal pain
  • Acute renal impairment in susceptible individuals

Precautions & Warnings

Before using Macrogol En Elektrolyten, consider the following safety measures.

  • Renal function: assess kidney function in patients with renal impairment.
  • Electrolyte disorders: avoid in individuals with significant electrolyte abnormalities.
  • Dehydration: ensure adequate fluid intake to prevent dehydration.
  • Bowel obstruction: contraindicated in patients with known or suspected mechanical obstruction.
  • Pediatric use: use under medical supervision for children.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Macrogol En Elektrolyten can interact with other medicines; awareness of these interactions helps maintain safety.

Major Interactions (Avoid)

  • Other osmotic laxatives (e.g., lactulose) – risk of excessive fluid loss.
  • Loop diuretics – may exacerbate electrolyte disturbances.
  • Certain antihypertensives (e.g., ACE inhibitors) – potential for additive hypotensive effect when combined with volume shifts.

Moderate Interactions (Monitor Closely)

  • Antacids containing magnesium or aluminum – may affect absorption of electrolytes.
  • Mineral supplements (e.g., calcium, iron) – could alter stool consistency.
  • Antibiotics such as quinolones – monitor for changes in gastrointestinal motility.

Frequently Asked Questions

Macrogol En Elektrolyten is an oral osmotic laxative that is used to relieve constipation, assist in the evacuation of faecal impaction, and to prepare the bowel before diagnostic procedures such as colonoscopy. It works by increasing water content in the stool, making it easier to pass.

Macrogol 3350 is a high‑molecular‑weight polyethylene glycol that is not absorbed from the gut. It retains water in the intestinal lumen through osmotic pressure, softening the stool and increasing its volume. The added electrolytes help maintain normal electrolyte balance while the increased fluid promotes peristalsis.

The dose of Macrogol En Elektrolyten is individualized by the prescribing healthcare professional based on the patient’s age, weight, severity of constipation and clinical situation. The prescriber determines the appropriate amount and frequency, and patients should follow the specific instructions provided on the prescription label.

Safety data for Macrogol En Elektrolyten in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Healthcare providers will evaluate the individual situation and advise whether the product is appropriate during pregnancy or while breastfeeding.

To place an order, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After the enquiry, the sales team will request trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements) and assist with import documentation.

Compared with stimulant laxatives, macrogol‑based products act osmotically and are generally better tolerated, causing fewer cramping and electrolyte disturbances. Unlike simple saline laxatives, the inclusion of electrolytes in Macrogol En Elektrolyten helps maintain fluid balance, making it suitable for longer‑term use under medical supervision.

Store Macrogol En Elektrolyten at ambient temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture, direct sunlight and extreme temperatures to preserve product stability and potency.

The product is supplied as an oral powder that is dissolved in water or another clear fluid according to the prescribing information. The solution is then consumed as directed by the healthcare professional, typically once daily or as needed for bowel cleansing.

Serious risks include electrolyte imbalance (such as hypernatremia or hypokalemia), severe dehydration, allergic reactions, and rare cases of intestinal obstruction or perforation, especially in patients with pre‑existing gastrointestinal pathology. Prompt medical attention is required if severe abdominal pain, persistent diarrhea, or signs of an allergic reaction occur.

Macrogol En Elektrolyten should be avoided in individuals with known or suspected mechanical bowel obstruction, severe renal impairment, uncontrolled electrolyte disorders, or hypersensitivity to any of its components. Pediatric use should be under strict medical supervision, and patients with a history of severe gastrointestinal disease should be evaluated before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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