Product image of Macrogol En Elektrolyten Naturel Sandoz (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350) supplied by GNH India

Macrogol En Elektrolyten Naturel Sandoz

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350
Origin:
EU

Macrogol En Elektrolyten Naturel Sandoz (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Macrogol 3350, the active ingredient in Macrogol En Elektrolyten Naturel Sandoz, is an osmotic laxative presented as an oral powder for oral use. It helps relieve constipation by retaining water in the intestinal lumen, primarily in adults and children with functional constipation.

GNH India supplies Macrogol En Elektrolyten Naturel Sandoz as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz B.V.

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Indications & Clinical Uses

Macrogol En Elektrolyten Naturel Sandoz is used to manage constipation and related gastrointestinal conditions.

  • Chronic constipation: provides bowel regularity by increasing stool water content.
  • Acute constipation: relieves temporary bowel irregularities.
  • Bowel preparation: assists in cleansing the colon before diagnostic procedures such as colonoscopy.

How It Works

  • Macrogol 3350 is a high‑molecular‑weight polyethylene glycol that is not absorbed from the gastrointestinal tract. It creates an osmotic gradient that draws water into the intestinal lumen, softening stool and increasing its volume, while the accompanying electrolytes maintain fluid balance, facilitating easier passage of feces.

Side Effects

Common Side Effects

  • Abdominal bloating: sensation of fullness or swelling in the abdomen.
  • Flatulence: increased intestinal gas production.
  • Nausea: feeling of unease or urge to vomit.
  • Diarrhea: loose, watery stools.
  • Abdominal cramps: painful muscle contractions in the gut.
  • Thirst: increased desire for fluids.

Serious or Rare Side Effects

  • Electrolyte imbalance: abnormal levels of sodium or potassium.
  • Severe dehydration: marked loss of body water.
  • Allergic reaction: rash, itching, or angioedema.
  • Severe abdominal pain: intense, persistent discomfort.
  • Rectal bleeding: presence of blood in stool.
  • Anaphylaxis: rare life‑threatening hypersensitivity response.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Assess renal function: adjust use in severe renal impairment.
  • Monitor electrolyte levels: especially potassium and sodium during prolonged therapy.
  • Use caution in patients with bowel obstruction: contraindicated in complete obstruction.
  • Avoid in patients with known hypersensitivity to macrogol or any component.
  • Pediatric dosing: follow prescriber guidance; not recommended for infants under 2 years without supervision.
  • Store at ambient temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Macrogol En Elektrolyten Naturel Sandoz may interact with other medicines as follows:

Major Interactions (Avoid)

  • Concomitant high‑dose laxatives: risk of severe electrolyte disturbance.
  • Loop diuretics: may exacerbate electrolyte loss.
  • Antacids containing sodium bicarbonate: may increase sodium load.

Moderate Interactions (Monitor Closely)

  • Oral rehydration solutions: monitor sodium balance.
  • Opioid analgesics: may reduce laxative efficacy.
  • Other oral medications: macrogol may affect absorption; monitor therapeutic levels where relevant.

Frequently Asked Questions

Macrogol En Elektrolyten Naturel Sandoz is an oral osmotic laxative indicated for the relief of constipation, including chronic and acute forms, and for bowel cleansing prior to diagnostic procedures such as colonoscopy. The formulation also contains electrolytes to help maintain fluid balance during treatment.

Macrogol 3350 is a high‑molecular‑weight polyethylene glycol that remains in the gastrointestinal tract and draws water into the lumen by osmosis. This increases stool water content, softens the stool, and promotes bowel movements while the added electrolytes help preserve normal serum electrolyte levels.

The appropriate dose of Macrogol En Elektrolyten Naturel Sandoz is determined by the prescribing healthcare professional based on the patient’s age, weight, severity of constipation, and clinical response. Patients should follow the prescriber’s instructions and the product’s labeling for preparation and administration.

Limited clinical data are available regarding use during pregnancy and lactation. The product should only be used if the prescriber judges that the potential benefit outweighs any possible risk to the fetus or infant. Women who are pregnant or breastfeeding should discuss safety with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details (including any cold‑chain requirements), and required import documentation.

Macrogol En Elektrolyten Naturel Sandoz belongs to the osmotic laxative class, which works by retaining water in the bowel. Compared with stimulant laxatives, it generally has a gentler onset and a lower risk of cramping. Unlike some saline laxatives, the added electrolytes help minimize fluid and electrolyte shifts, making it suitable for longer‑term use under medical supervision.

Store the product at ambient temperature, preferably below 25 °C, in its original packaging. Protect it from moisture, direct sunlight, and excessive heat. Ensure the container is tightly closed after each use to maintain product stability and prevent contamination.

The product is supplied as an oral powder that is reconstituted with water according to the instructions on the label. The resulting solution is taken by mouth, usually once daily or as directed by the prescriber. The dose may be adjusted based on clinical response and tolerability.

Serious risks include electrolyte imbalance (particularly sodium or potassium disturbances), severe dehydration, and rare allergic reactions such as rash, angioedema, or anaphylaxis. Patients experiencing severe abdominal pain, persistent diarrhea, or signs of electrolyte disturbance should seek medical attention promptly.

The product should be avoided in individuals with known hypersensitivity to macrogol or any of its components, in patients with complete bowel obstruction, and in those with severe renal impairment unless specifically advised by a physician. It is also contraindicated in patients with certain metabolic disorders where electrolyte shifts could be hazardous.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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