Product image of Macrogol Neuraxpharm (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350) supplied by GNH India

Macrogol Neuraxpharm

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350
Origin:
EU

Macrogol Neuraxpharm (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Macrogol 3350, the active ingredient in Macrogol Neuraxpharm, is an osmotic laxative presented as an oral solution for oral use. It works by retaining water in the intestinal lumen, softening stool and facilitating bowel movements in patients with constipation, including adults and children. The formulation also contains sodium hydrogen carbonate, potassium chloride and sodium chloride to maintain electrolyte balance.

GNH India supplies Macrogol Neuraxpharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Neuraxpharm Arzneimittel Gmbh

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Macrogol Neuraxpharm, an osmotic laxative, is used to manage conditions involving impaired bowel motility or hard stools.

  • Chronic constipation: softens stool and promotes regular bowel movements in adults and children.
  • Opioid‑induced constipation: counteracts opioid‑related reduction in intestinal water content to restore normal defecation.
  • Functional constipation: improves stool consistency and frequency in patients with functional bowel disorders.

How It Works

  • Macrogol 3350 creates an osmotic gradient within the intestinal lumen that draws water into the bowel. The increased luminal water content softens fecal mass and expands stool volume, stimulating peristalsis and facilitating the passage of stool without being absorbed systemically.

Side Effects

Macrogol Neuraxpharm may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Abdominal bloating: sensation of fullness or swelling in the abdomen.
  • Flatulence: increased intestinal gas leading to discomfort.
  • Nausea: feeling of unease or urge to vomit.
  • Abdominal cramps: intermittent painful contractions of the gut.
  • Diarrhoea: loose, watery stools occurring with higher doses.
  • Thirst: increased desire for fluids.

Serious or Rare Side Effects

  • Electrolyte imbalance: abnormal levels of sodium, potassium or chloride.
  • Severe dehydration: excessive loss of body water.
  • Allergic reaction: rash, itching, swelling or difficulty breathing.
  • Intestinal obstruction: worsening blockage in patients with existing obstruction.
  • Severe abdominal pain: intense, persistent pain requiring medical attention.

Precautions & Warnings

Before initiating therapy with Macrogol Neuraxpharm, consider the following precautions.

  • Assess hydration status: ensure the patient is adequately hydrated to reduce risk of dehydration.
  • Monitor electrolytes: check sodium, potassium and chloride levels, especially in long‑term use.
  • Adjust dose in renal impairment: reduce dosage or increase monitoring in patients with reduced kidney function.
  • Use cautiously in inflammatory bowel disease: avoid if active obstruction or severe disease is present.
  • Avoid in known hypersensitivity: discontinue if allergic signs appear.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Macrogol Neuraxpharm can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Anticholinergic agents: may reduce the laxative effect of macrogol.
  • Opioid analgesics: can exacerbate constipation, requiring combined therapy.
  • Mineral oil: increased risk of aspiration and reduced effectiveness.

Moderate Interactions (Monitor Closely)

  • Diuretics: potential for additive electrolyte disturbances.
  • ACE inhibitors: may affect potassium balance when combined.
  • NSAIDs: increased risk of gastrointestinal irritation when used together.

Frequently Asked Questions

Macrogol Neuraxpharm is an oral osmotic laxative indicated for the treatment of constipation, including chronic, functional, and opioid‑induced constipation. It works by increasing water content in the intestines, which softens stool and promotes regular bowel movements.

Macrogol 3350 is a high‑molecular‑weight polymer that is not absorbed from the gastrointestinal tract. It creates an osmotic gradient that draws water into the lumen of the intestine, softening the stool and expanding its volume, which stimulates peristalsis and facilitates stool passage.

The prescribed dose of Macrogol Neuraxpharm is determined by the treating physician based on the patient’s age, weight, severity of constipation and clinical response. The prescriber will provide specific dosing instructions tailored to the individual’s needs.

Safety data for Macrogol Neuraxpharm in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Compared with stimulant laxatives, macrogol 3350 provides a gentler, osmotic mechanism that is less likely to cause cramping or dependence. It is often preferred for long‑term management of constipation because it works by retaining water in the stool rather than stimulating intestinal muscle activity.

Macrogol Neuraxpharm should be stored at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use.

The medication is supplied as an oral solution that is taken by mouth. It may be mixed with a small amount of water or other suitable liquid as directed by the prescriber, and should be consumed according to the dosing schedule provided.

Serious risks include severe dehydration, electrolyte disturbances (especially sodium, potassium, and chloride), and rare allergic reactions such as rash, swelling or difficulty breathing. Patients should seek immediate medical attention if they experience these symptoms.

Macrogol Neuraxpharm should be avoided in individuals with known hypersensitivity to macrogol or any of its excipients, in patients with intestinal obstruction, perforation, or severe inflammatory bowel disease, and in those where electrolyte balance cannot be safely monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT