Product image of Macrogol Norgine Neutral (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350) supplied by GNH India

Macrogol Norgine Neutral

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350
Origin:
EU

Macrogol Norgine Neutral (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Macrogol 3350, the active ingredient in Macrogol Norgine Neutral, is an osmotic laxative presented as a solution for oral use. It is employed to relieve constipation in adults and children by softening stool and facilitating bowel movements.

GNH India supplies Macrogol Norgine Neutral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. Our network ensures timely delivery and regulatory support across multiple regions.

Manufacturer / TM Owner

Norgine Healthcare B.V.

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Indications & Clinical Uses

Macrogol Norgine Neutral, an osmotic laxative, is used to manage constipation.

  • Constipation: softens stool and promotes regular bowel movements.
  • Occasional constipation: provides relief for intermittent bowel irregularities.
  • Chronic constipation: aids long‑term management in adults and children.

How It Works

  • Macrogol 3350 acts as an osmotic agent that remains largely non‑absorbed in the gastrointestinal tract. It draws water into the intestinal lumen by increasing the osmotic pressure, which hydrates the fecal mass, reduces its viscosity and facilitates transit. The accompanying electrolytes (sodium hydrogen carbonate, potassium chloride, sodium chloride) maintain isotonic balance, supporting safe and effective stool softening. The increased luminal water content also stimulates peristalsis, enhancing bowel motility.

Side Effects

Macrogol Norgine Neutral may cause adverse reactions, which are categorized by frequency.

Common Side Effects

  • Abdominal bloating
  • Flatulence
  • Nausea
  • Abdominal cramps
  • Diarrhea

Serious or Rare Side Effects

  • Electrolyte imbalance (e.g., hyponatremia, hypokalemia)
  • Severe dehydration
  • Allergic reaction (rash, angioedema, anaphylaxis)

Precautions & Warnings

Precautions should be observed when prescribing Macrogol Norgine Neutral.

  • Assess renal function: evaluate kidney status before initiating therapy.
  • Monitor electrolytes: check serum sodium and potassium during prolonged use.
  • Use with caution in dehydration: ensure adequate fluid intake.
  • Avoid in intestinal obstruction: contraindicated in mechanical blockage.
  • Do not exceed recommended duration: limit use to short‑term unless advised.
  • Store at ambient temperature: keep in original container, protect from moisture.

Avoid Interactions

Potential drug interactions require attention.

Major Interactions (Avoid)

  • Concurrent osmotic laxatives: risk of excessive fluid loss and electrolyte disturbance.
  • Loop diuretics: may amplify electrolyte depletion.
  • Mineral oil: can reduce absorption of the laxative.

Moderate Interactions (Monitor Closely)

  • Antacids containing sodium: may alter electrolyte balance.
  • NSAIDs: combined use may affect renal function.
  • ACE inhibitors: monitor for additive potassium changes.

Frequently Asked Questions

Macrogol Norgine Neutral is an oral osmotic laxative indicated for the relief of constipation. It works by softening stool and increasing intestinal water content, helping to restore regular bowel movements in adults and children.

Macrogol 3350 remains largely non‑absorbed in the gut and creates an osmotic gradient that draws water into the intestinal lumen. The added water softens the fecal mass, reduces its viscosity, and promotes peristalsis, facilitating easier passage of stool.

The dose of Macrogol Norgine Neutral is individualized and set by the prescribing healthcare professional based on the patient’s age, severity of constipation, and clinical response. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Macrogol Norgine Neutral during pregnancy and lactation are limited. It should only be used if clearly needed and after a risk‑benefit assessment by the prescriber. Breastfeeding mothers should consult their healthcare provider before use.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with stimulant laxatives, Macrogol Norgine Neutral works by osmotic water retention rather than stimulating intestinal muscle activity, resulting in a gentler, more physiologic stool softening. It is generally preferred for long‑term or chronic constipation due to its favorable safety profile.

Store the solution at ambient temperature, preferably below 25 °C. Keep the container tightly closed, protect it from moisture and direct sunlight, and ensure it is out of reach of children. Do not freeze the product.

Macrogol Norgine Neutral is taken orally as a liquid solution. The prescribed volume is measured using the provided dosing device or a calibrated syringe, then ingested with a glass of water. It should be taken as directed by the prescriber.

Serious risks include electrolyte imbalance (especially low sodium or potassium), severe dehydration, and rare allergic reactions such as rash, angioedema or anaphylaxis. Patients experiencing these symptoms should seek medical attention promptly.

Macrogol Norgine Neutral should be avoided in individuals with known hypersensitivity to any component, in cases of intestinal obstruction, perforation, or severe dehydration, and in patients with renal impairment where electrolyte monitoring is not feasible.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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