Product image of Macrogol Plus Elektrolyte Dexcel (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350) supplied by GNH India

Macrogol Plus Elektrolyte Dexcel

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350
Origin:
EU

Macrogol Plus Elektrolyte Dexcel (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Macrogol 3350, the active ingredient in Macrogol Plus Elektrolyte Dexcel, is an osmotic laxative presented as an oral solution for oral use. It is indicated for the relief of constipation in adults and children, helping to soften stool and promote regular bowel movements.

GNH India supplies Macrogol Plus Elektrolyte Dexcel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution. This ensures reliable supply chains and timely delivery to end‑users.

Manufacturer / TM Owner

Dexcel Pharma Gmbh

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Indications & Clinical Uses

  • Macrogol Plus Elektrolyte Dexcel is an osmotic laxative used to manage constipation and related bowel motility disorders.
  • Constipation: softens stool and facilitates regular bowel movements in adults and children.
  • Opioid‑induced constipation: counteracts opioid‑related reduced gut motility, improving stool passage.
  • Post‑operative ileus: assists in restoring bowel function after abdominal surgery by drawing water into the intestinal lumen.

How It Works

  • Macrogol 3350 creates an osmotic gradient within the intestinal lumen, retaining water and increasing stool water content. The accompanying electrolytes (sodium hydrogen carbonate, potassium chloride, sodium chloride) maintain fluid and electrolyte balance while the solution remains in the gut. The resulting softened, voluminous stool stimulates peristalsis, promoting bowel evacuation without being absorbed systemically. This mechanism operates locally in the gastrointestinal tract and does not involve systemic pharmacologic activity.

Side Effects

Macrogol Plus Elektrolyte Dexcel may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Abdominal bloating
  • Flatulence
  • Nausea
  • Diarrhea

Serious or Rare Side Effects

  • Electrolyte imbalance (e.g., hyponatremia, hypokalemia)
  • Severe dehydration
  • Allergic reaction (rash, itching, swelling)

Precautions & Warnings

  • When using Macrogol Plus Elektrolyte Dexcel, consider the following precautions.
  • Renal function assessment: evaluate kidney function before initiating therapy, especially in patients with renal impairment.
  • Electrolyte monitoring: check serum electrolytes periodically during prolonged use.
  • Bowel obstruction caution: avoid use in patients with known or suspected mechanical obstruction.
  • Hypersensitivity warning: discontinue if signs of allergic reaction such as rash or swelling appear.
  • Elderly dose consideration: start with the lowest effective dose in older adults.
  • Store at ambient temperature: keep the solution in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Potential drug interactions should be reviewed before prescribing Macrogol Plus Elektrolyte Dexcel.

Major Interactions (Avoid)

  • Concomitant use with other osmotic laxatives: may cause excessive fluid loss.
  • Use with potent diuretics: increased risk of electrolyte disturbances.
  • Combination with mineral oil: may reduce laxative efficacy.

Moderate Interactions (Monitor Closely)

  • Opioid analgesics: may diminish laxative effect, requiring dose adjustment.
  • Anticholinergic agents: may lessen gastrointestinal motility, reducing product effectiveness.

Frequently Asked Questions

Macrogol Plus Elektrolyte Dexcel is an oral osmotic laxative indicated for the relief of constipation. It works by increasing the water content of stool, making it softer and easier to pass, and is used in both adult and pediatric patients with functional or chronic constipation.

Macrogol 3350 creates an osmotic gradient in the intestinal lumen that draws water into the bowel. The added electrolytes help maintain fluid balance while the increased stool water softens the feces and stimulates peristalsis, facilitating natural bowel movements without systemic absorption.

The appropriate dose is individualized by the prescribing clinician based on the patient’s age, severity of constipation, renal function, and response to therapy. The prescriber will select the volume of oral solution that provides the required amount of macrogol 3350 and electrolytes for each specific case.

Safety data in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified health professional after evaluating the clinical situation.

Enquiries can be submitted through the product page on gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details and any necessary import documentation.

Compared with stimulant laxatives, macrogol 3350 works locally by osmotic water retention rather than stimulating intestinal nerves, resulting in a gentler effect and lower risk of cramping. Unlike bulk‑forming agents, it does not rely on dietary fiber and can be used when fluid intake is limited, while the added electrolytes help prevent imbalances.

Store the oral solution at ambient temperature, preferably below 25 °C. Keep the container tightly closed, protect it from moisture, direct sunlight and extreme temperatures. Do not freeze the solution, and ensure the label remains legible throughout its shelf life.

The product is taken orally as a measured volume of the liquid solution. It should be consumed with a glass of water or other fluid, and the dose may be adjusted by the prescriber according to the patient’s response and clinical needs.

Serious adverse events, although rare, include significant electrolyte disturbances such as hyponatremia or hypokalemia, severe dehydration, and allergic reactions that may present as rash, itching, swelling or anaphylaxis. Prompt medical attention is required if any of these symptoms develop.

The product should be avoided in individuals with known hypersensitivity to macrogol or any of the electrolyte components, in patients with mechanical bowel obstruction, and in those with severe renal impairment where electrolyte handling is compromised. A healthcare professional should assess suitability before initiation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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