Macrogol (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Macrogol is a high‑molecular‑weight polyethylene glycol that remains in the gastrointestinal tract. It binds water molecules, creating an osmotic gradient that draws fluid into the intestinal lumen, softening stool and stimulating peristalsis without being absorbed into the bloodstream.

The dose of Macrogol is individualized by the prescribing healthcare professional based on the patient’s age, weight, severity of constipation, and the intended use (treatment versus bowel preparation). Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Macrogol should be used during pregnancy or lactation only if clearly needed and after a risk‑benefit assessment by a qualified healthcare provider. Limited data are available, so the prescriber will decide whether the benefits outweigh potential risks.

To order Macrogol, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Compared with stimulant laxatives, Macrogol works by an osmotic mechanism, generally causing fewer cramping sensations and less electrolyte disturbance. It is often preferred for long‑term constipation management and for bowel cleansing before procedures, whereas stimulant agents act by stimulating intestinal muscle contractions.

Macrogol should be stored below 25 °C in its original packaging, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid exposing it to high humidity, which could affect its stability.

Macrogol is taken orally, usually dissolved in a measured amount of water or other clear fluid as directed by the prescriber. It is important to drink the full volume of liquid to ensure proper distribution of the osmotic agent throughout the gastrointestinal tract.

Serious risks include severe electrolyte imbalance, acute renal failure, and allergic reactions such as rash or angioedema. Patients should seek immediate medical attention if they experience symptoms like persistent vomiting, severe abdominal pain, swelling of the face or throat, or sudden changes in blood pressure.

Macrogol should be avoided in individuals with known hypersensitivity to polyethylene glycol, those with intestinal obstruction, perforation, or severe inflammatory bowel disease, and patients with uncontrolled electrolyte abnormalities or severe renal impairment unless closely monitored by a physician.