Product image of Macrolief (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350) supplied by GNH India

Macrolief

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350
Origin:
EU

Macrolief (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350, the active ingredients in Macrolief, is an electrolyte and osmotic laxative preparation presented as an oral solution for oral use. It is employed to aid bowel cleansing, relieve constipation, and restore electrolyte balance in mild dehydration.
GNH India supplies Macrolief as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Rowex Ltd

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Indications & Clinical Uses

Macrolief, a combination electrolyte and osmotic laxative, is used in gastrointestinal conditions that require bowel cleansing or fluid replacement.

  • Colonoscopy preparation: facilitates bowel cleansing by osmotic action to empty the colon.
  • Chronic constipation: softens stool and promotes regular bowel movements.
  • Electrolyte replacement: restores sodium, potassium, and chloride balance in mild dehydration.

How It Works

  • Macrolief works by the osmotic activity of macrogol 3350, a high‑molecular‑weight polymer that retains water in the intestinal lumen, increasing stool water content and promoting evacuation. The accompanying electrolytes (sodium hydrogen carbonate, potassium chloride, sodium chloride) maintain osmotic balance and help correct electrolyte deficits during the cleansing process.

Side Effects

Macrolief may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Abdominal bloating: feeling of fullness or swelling in the abdomen.
  • Nausea: mild to moderate sensation of wanting to vomit.
  • Flatulence: increased intestinal gas.
  • Mild abdominal cramps: intermittent discomfort.
  • Diarrhea: loose stools occurring after dosing.
  • Mild electrolyte imbalance: slight changes in sodium or potassium levels.

Serious or Rare Side Effects

  • Severe dehydration: excessive fluid loss requiring medical attention.
  • Severe electrolyte disturbances: hypernatremia, hyperkalemia, or hyponatremia.
  • Allergic reaction: rash, itching, or swelling.
  • Anaphylaxis: rare, life‑threatening hypersensitivity.
  • Severe abdominal pain: persistent or worsening pain.
  • Intestinal perforation: extremely rare but serious gastrointestinal injury.

Precautions & Warnings

When prescribing or using Macrolief, consider the following safety measures.

  • Assess renal function: adjust use in patients with renal impairment.
  • Monitor electrolyte levels: especially in individuals with cardiac disease or on diuretics.
  • Use caution in severe constipation: risk of impaction if bowel is obstructed.
  • Avoid in known hypersensitivity: discontinue if allergic signs appear.
  • Pregnant or breastfeeding women: consult a healthcare professional before use.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Macrolief can interact with other medicines; some combinations should be avoided while others require monitoring.

Major Interactions (Avoid)

  • Other osmotic laxatives: may cause excessive fluid loss.
  • High‑dose potassium supplements: increase risk of hyperkalemia.
  • Sodium‑containing medications: risk of sodium overload.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may exacerbate electrolyte shifts.
  • ACE inhibitors or ARBs: monitor potassium levels.
  • Lithium therapy: altered lithium concentrations.
  • Digoxin: electrolyte changes may affect toxicity risk.

Frequently Asked Questions

Macrolief is an oral solution that combines electrolytes with macrogol 3350. It is used to cleanse the bowel before procedures such as colonoscopy, to relieve occasional constipation, and to help restore electrolyte balance in mild dehydration.

The macrogol 3350 component is a non‑absorbable polymer that draws water into the intestinal lumen, softening stool and promoting evacuation. The added electrolytes (sodium hydrogen carbonate, potassium chloride, sodium chloride) maintain osmotic balance and replace lost minerals during the cleansing process.

The dose of Macrolief is individualized by the prescribing healthcare professional based on the indication, patient age, weight, and clinical condition. Patients should follow the exact instructions provided by their prescriber and not alter the dose on their own.

Safety of Macrolief in pregnancy or while breastfeeding has not been fully established. Women who are pregnant, planning to become pregnant, or nursing should discuss potential risks and benefits with their healthcare provider before using the product.

To request Macrolief, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Macrolief combines an osmotic laxative (macrogol 3350) with electrolytes, offering effective bowel cleansing while helping to maintain mineral balance. Compared with sodium‑phosphate preparations, it generally has a lower risk of severe electrolyte disturbances, but individual response may vary.

Macrolief should be stored at ambient temperature, below 25 °C. Keep the container tightly closed, protect it from moisture and direct sunlight, and store it in its original packaging until use.

Macrolief is taken orally as a liquid solution. The prescribed volume is usually mixed with a specified amount of water or clear fluid and consumed according to the prescriber’s schedule, often in divided doses throughout the day.

Serious risks include severe dehydration, significant electrolyte disturbances such as hypernatremia or hyperkalemia, allergic reactions including anaphylaxis, and, rarely, intestinal perforation. Patients should seek immediate medical attention if they experience severe abdominal pain, persistent vomiting, or signs of an allergic reaction.

Macrolief should be avoided in individuals with known hypersensitivity to any of its components, in patients with severe renal impairment without medical supervision, and in those with intestinal obstruction or perforation. Consultation with a healthcare professional is essential before use in these situations.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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