Product image of Macrolyte (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350) supplied by GNH India

Macrolyte

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350
Origin:
EU

Macrolyte (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Sodium hydrogen carbonate, the active ingredient in Macrolyte, is an electrolyte solution presented as an oral solution for oral use. It helps restore fluid and electrolyte balance in individuals experiencing dehydration or electrolyte loss.

GNH India supplies Macrolyte as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Norgine Pharmaceuticals Limited

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Indications & Clinical Uses

Macrolyte is used to address conditions that involve fluid loss and electrolyte disturbances.

  • Dehydration: Replenishes lost water and essential electrolytes to re‑hydrate the body.
  • Electrolyte imbalance: Restores normal sodium, potassium and chloride levels.
  • Oral rehydration: Provides a convenient oral solution for managing mild to moderate fluid deficits.

How It Works

  • Macrolyte restores fluid and electrolyte balance by delivering sodium, potassium, and chloride ions together with macrogol 3350, an osmotic agent that draws water into the intestinal lumen. The combined electrolyte load supports plasma osmolality, while macrogol 3350 enhances water absorption, facilitating rapid rehydration without significant shifts in intracellular compartments.

Side Effects

Macrolyte may cause mild, transient reactions in some users.

Common Side Effects

  • Nausea: mild stomach upset after ingestion.
  • Abdominal discomfort: mild cramping or bloating.
  • Mild diarrhea: loose stools due to osmotic activity.

Serious or Rare Side Effects

  • Hypernatremia: elevated blood sodium levels, especially if excessive volumes are consumed.
  • Hyperkalemia: increased potassium levels, particularly in patients with renal impairment.
  • Allergic reaction: rash, itching or swelling indicating hypersensitivity.

Precautions & Warnings

Use Macrolyte with attention to individual health status and monitoring requirements.

  • Assess fluid status: evaluate dehydration severity before administration.
  • Monitor electrolytes: check serum sodium and potassium during prolonged use.
  • Renal impairment: adjust volume in patients with reduced kidney function.
  • Hypernatremia risk: avoid excessive dosing in patients already sodium‑loaded.
  • Do not exceed recommended volume: follow prescriber guidance.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Macrolyte can interact with other medications that affect electrolyte balance.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics: may cause dangerous hyperkalemia.
  • ACE inhibitors or ARBs: can increase potassium levels when combined.
  • Sodium‑restricted diets: may lead to excess sodium intake.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may impair renal function, altering electrolyte handling.
  • Antacids containing sodium: additive sodium load may affect balance.
  • Intravenous fluid therapy: concurrent use may cause fluid overload if not monitored.

Frequently Asked Questions

Macrolyte is an oral electrolyte solution designed to treat dehydration, correct electrolyte imbalances, and provide oral rehydration therapy. It supplies sodium, potassium, chloride and an osmotic agent to help restore normal fluid balance in patients who have lost fluids due to illness, heat exposure, or gastrointestinal losses.

Sodium hydrogen carbonate contributes sodium ions that help maintain plasma osmolality and support water absorption in the intestines. Together with potassium chloride, sodium chloride and macrogol 3350, it creates an isotonic environment that facilitates rapid rehydration while correcting electrolyte deficits.

The appropriate dose of Macrolyte is determined by the prescribing healthcare professional based on the patient’s age, weight, degree of dehydration and electrolyte status. The prescriber will specify the volume and frequency needed to achieve safe and effective rehydration.

Safety data for Macrolyte in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and under the guidance of a qualified healthcare provider.

To order Macrolyte, submit an enquiry on the product page at gnhindia.com, providing the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then replies with pricing, availability, shipping details and any necessary import documentation.

Macrolyte contains a balanced mix of sodium, potassium, chloride and macrogol 3350, offering both electrolyte replacement and an osmotic agent for enhanced water absorption. Compared with standard ORS formulations that may lack macrogol, Macrolyte can provide more efficient fluid uptake, especially in cases of moderate to severe dehydration.

Macrolyte should be stored at ambient temperature, below 25 °C. Keep the container tightly closed, protect it from moisture and direct sunlight, and store it in its original packaging to maintain product stability.

Macrolyte is taken orally. The prescribed volume is measured using a calibrated cup or syringe and consumed slowly. It may be given in divided doses throughout the day, depending on the severity of dehydration and the prescriber’s instructions.

Serious risks include hypernatremia or hyperkalemia if excessive amounts are ingested, especially in patients with renal impairment or those receiving other electrolyte‑containing therapies. Allergic reactions such as rash, itching or swelling may also occur and require immediate medical attention.

Macrolyte should be avoided in individuals with known hypersensitivity to any of its ingredients, in patients with severe hypernatremia or hyperkalemia, and in those with conditions that require strict fluid or electrolyte restriction unless directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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