Product image of Macroagregados De Albúmina Humana (Macrosalb (99mtc)) supplied by GNH India

Macroagregados De Albúmina Humana

Active Ingredient:
Macrosalb (99mtc)
Origin:
EU

Macroagregados De Albúmina Humana (Macrosalb (99mtc))

Technetium-99m macroaggregated human albumin, the active ingredient in Macroagregados De Albúmina Humana, is a radiopharmaceutical presented as a kit for preparation of a radiopharmaceutical solution for intravenous use. It is employed in nuclear medicine to assess pulmonary blood flow by labeling albumin particles that temporarily lodge in the lung capillaries, enabling lung perfusion imaging in adult and pediatric patients undergoing ventilation‑perfusion (V/Q) scans.

GNH India supplies Macroagregados De Albúmina Humana as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Medi-Radiopharma Kft.

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Indications & Clinical Uses

Technetium‑99m macroaggregated human albumin is used in nuclear medicine to evaluate pulmonary perfusion and related diagnostic pathways.

  • Lung perfusion imaging: provides visualization of regional pulmonary blood flow for diagnostic assessment.
  • Ventilation‑perfusion (V/Q) scan: assists in detecting pulmonary embolism by comparing ventilation and perfusion patterns.
  • Pre‑operative assessment: helps evaluate lung function before thoracic or cardiac surgery.

How It Works

  • After intravenous injection, the technetium‑99m label binds to macroaggregated albumin particles that are 10–90 µm in size. These particles become temporarily trapped in the pulmonary capillary bed, creating a localized gamma‑emitting source. A gamma camera detects the emitted photons, producing a perfusion map of the lungs that reflects regional blood flow and enables diagnostic interpretation.

Side Effects

Common Side Effects

  • Mild headache: transient discomfort after injection.
  • Nausea: occasional feeling of queasiness.
  • Injection site pain: brief soreness at the venipuncture site.
  • Transient flushing: brief skin redness.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Pulmonary hypertension: sudden increase in pulmonary arterial pressure.
  • Embolic phenomena: rare lodging of particles causing vascular obstruction.
  • Radiation‑induced skin injury: localized skin changes at high exposure levels.

Precautions & Warnings

Precautions should be observed to ensure safe use of this radiopharmaceutical.

  • Patient selection: confirm indication and assess for contraindications.
  • Pregnancy: avoid unless the diagnostic benefit outweighs potential fetal risk.
  • Breastfeeding: consider temporary cessation or alternative imaging.
  • Renal function: evaluate because excretion may be altered.
  • Radiation safety: follow ALARA principles and protect staff.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Interactions with other agents may affect imaging quality or safety.

Major Interactions (Avoid)

  • Concurrent radiopharmaceuticals emitting similar gamma energies: may cause image overlap.
  • High‑dose iodine contrast agents: can interfere with technetium detection.
  • Certain chemotherapeutic agents affecting bone marrow: increase radiation sensitivity.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may alter heart rate influencing perfusion patterns.
  • Diuretics: can modify pulmonary blood flow distribution.
  • ACE inhibitors: may affect capillary dynamics during imaging.

Frequently Asked Questions

Macroagregados De Albúmina Humana is a radiopharmaceutical used in nuclear medicine to visualize pulmonary blood flow. It is administered intravenously before a ventilation‑perfusion (V/Q) scan or lung perfusion study, helping clinicians diagnose conditions such as pulmonary embolism and assess lung function before surgery.

The compound consists of albumin particles labeled with technetium‑99m. After injection, the particles lodge in the small vessels of the lung capillary network. The technetium‑99m emits gamma photons that are captured by a gamma camera, producing a detailed image of regional lung perfusion.

The dose of Technetium‑99m macroaggregated human albumin is determined by the prescribing physician or nuclear medicine specialist. The amount is calculated based on the patient’s age, weight, and the specific imaging protocol, and is prepared from the supplied kit immediately before administration.

Safety in pregnancy and breastfeeding has not been definitively established. Use is generally avoided unless the diagnostic information is essential and cannot be obtained by alternative methods. If administered, the potential radiation exposure to the fetus or infant should be carefully considered and discussed with a specialist.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and the necessary import documentation.

Technetium‑99m macroaggregated human albumin is the standard agent for lung perfusion imaging because of its optimal particle size, reliable capillary trapping, and well‑characterized radiation profile. Alternative agents, such as newer radiolabeled compounds, may offer different imaging characteristics but are less widely validated and may not be available in all regions.

The kit should be stored at 2‑8 °C, protected from light, and kept in its original packaging. Do not freeze or shake the vial. Before use, reconstitute according to the manufacturer’s instructions in a clean, aseptic environment to maintain sterility and radiochemical integrity.

The reconstituted solution is administered intravenously, typically as a rapid bolus injection. Administration is performed by qualified healthcare personnel in a nuclear medicine suite, with appropriate radiation safety measures in place to protect both the patient and staff.

Serious risks include severe allergic reactions such as anaphylaxis, unexpected pulmonary hypertension, and rare embolic events caused by particle aggregation. Radiation exposure is also a consideration; therefore, the lowest effective activity should be used and all radiation protection guidelines must be followed.

Patients with known hypersensitivity to albumin, technetium‑99m, or any component of the kit should not receive the product. It is also contraindicated in pregnant women unless absolutely necessary, and in individuals where the diagnostic benefit does not outweigh the potential radiation risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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