Product image of Macrosalb (Macrosalb (99mtc)) supplied by GNH India

Macrosalb

Active Ingredient:
Macrosalb (99mtc)
Origin:
EU

Macrosalb (Macrosalb (99mtc))

Macrosalb, the active ingredient in Macrosalb, is a radiopharmaceutical presented as a kit for preparation of radiopharmaceutical solution for intravenous injection for diagnostic imaging use. It is employed to evaluate lung perfusion and to detect pulmonary embolism in patients undergoing nuclear medicine studies.

GNH India supplies Macrosalb as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Medi-Radiopharma Kft.

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Indications & Clinical Uses

Macrosalb is used in nuclear medicine procedures that assess pulmonary blood flow and related disorders.

  • Lung perfusion imaging: provides quantitative visualization of regional pulmonary blood flow for functional assessment.
  • Pulmonary embolism detection: helps identify obstructed vessels caused by emboli during ventilation‑perfusion scans.
  • Pre‑operative lung assessment: evaluates pulmonary reserve before major thoracic or cardiac surgery.

How It Works

  • After intravenous injection, the macroaggregated albumin particles travel through the right heart and become temporarily lodged in the pulmonary capillary bed. Their size restricts passage beyond the pulmonary circulation, allowing gamma camera detection of the radiolabel and producing a map of regional lung perfusion for diagnostic interpretation.

Side Effects

Common Side Effects

  • Mild chest discomfort: transient sensation during or after injection.
  • Transient cough: brief coughing episode post‑administration.
  • Low‑grade fever: short‑lived temperature rise.
  • Headache: mild, self‑limiting.
  • Nausea: occasional mild nausea.
  • Injection site pain: brief localized discomfort.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate medical attention.
  • Pulmonary hypertension: rare increase in pulmonary arterial pressure.
  • Embolization‑related infarction: unintended blockage causing tissue injury.
  • Radiation‑induced skin injury: localized skin changes at injection site.
  • Severe hypotension: sudden drop in blood pressure.
  • Cardiac arrhythmia: abnormal heart rhythm episodes.

Precautions & Warnings

Before using Macrosalb, consider the following precautions:

  • Patient selection: assess for underlying pulmonary hypertension or severe cardiopulmonary disease.
  • Pregnancy: avoid unless clearly needed, as fetal exposure to radiation is uncertain.
  • Breastfeeding: discontinue nursing for an appropriate period after administration.
  • Thyroid function: evaluate in patients with known thyroid disorders due to iodine content.
  • Hypersensitivity: confirm no known allergy to albumin or radiopharmaceutical components.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Macrosalb may interact with other agents that affect pulmonary circulation or imaging results.

Major Interactions (Avoid)

  • Anticoagulants: increased risk of bleeding complications.
  • Pulmonary vasodilators: may alter distribution of macroaggregates.
  • Concurrent radiopharmaceuticals with overlapping emission spectra: can interfere with image interpretation.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may affect heart rate and particle transit.
  • ACE inhibitors: potential impact on pulmonary vascular tone.
  • Diuretics: influence intravascular volume and capillary lodging.
  • Thyroid hormone therapy: may modify iodine handling.
  • Iodinated contrast agents: could affect radiotracer biodistribution.

Frequently Asked Questions

Macrosalb is a radiopharmaceutical used in nuclear medicine to assess lung perfusion and to help detect pulmonary embolism. It is administered intravenously and visualized with a gamma camera during ventilation‑perfusion (V/Q) scans, providing functional information about blood flow in the lungs.

Macrosalb consists of macroaggregated albumin particles labeled with a radioactive isotope. After injection, the particles become temporarily trapped in the pulmonary capillaries, creating a map of regional blood flow that can be captured by gamma imaging, allowing clinicians to evaluate lung perfusion patterns.

The dose of Macrosalb is determined by the prescribing physician or nuclear medicine specialist based on the specific imaging protocol, patient characteristics, and regulatory guidelines. The preparation is supplied as a kit that is reconstituted and administered according to the prescriber’s instructions.

Safety of Macrosalb in pregnancy and breastfeeding has not been fully established. It should be used only if the potential diagnostic benefit outweighs the theoretical risk to the fetus or infant, and appropriate precautions, such as minimizing exposure, should be taken.

To order Macrosalb, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Macrosalb is a macroaggregated albumin‑based radiopharmaceutical, similar to other V/Q scan agents such as Tc‑99m macroaggregated albumin. Compared with alternatives, it offers comparable imaging quality and particle size distribution, but selection may depend on local regulatory approvals, availability, and specific imaging protocols.

Macrosalb kits should be stored at ambient temperature, protected from moisture and direct sunlight, and kept in the original sealed packaging until use. Follow the manufacturer’s instructions for reconstitution and avoid shaking the vial to maintain particle integrity.

Macrosalb is prepared according to the kit instructions and administered as an intravenous injection. The injection is performed by qualified healthcare personnel in a controlled setting, typically immediately before the gamma camera imaging session.

Serious risks include rare allergic reactions such as anaphylaxis, pulmonary hypertension, embolization‑related tissue infarction, radiation‑induced skin injury, severe hypotension, and cardiac arrhythmias. Patients should be monitored closely during and after administration for any adverse signs.

Macrosalb is contraindicated in patients with known hypersensitivity to albumin or any component of the kit, and it should be used with caution in individuals with severe pulmonary hypertension, uncontrolled cardiac disease, or pregnant and breastfeeding women unless absolutely necessary.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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