Product image of Macrosalb Medi-Radiopharma (Human Albumin As Macroaggregates) supplied by GNH India

Macrosalb Medi-Radiopharma

Active Ingredient:
Human Albumin As Macroaggregates
Origin:
EU

Macrosalb Medi-Radiopharma (Human Albumin As Macroaggregates)

Human Albumin Macroaggregates, the active ingredient in Macrosalb Medi‑Radiopharma, is an albumin macroaggregate presented as a solution for injection for intravenous use. It serves as a diagnostic radiopharmaceutical, providing a radiographic marker for lung perfusion imaging in patients undergoing ventilation‑perfusion (V/Q) scans. The product carries ATC code V09EA02 and is marketed in the European Union for use by nuclear medicine specialists.

GNH India supplies Macrosalb Medi‑Radiopharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, diagnostic imaging centres and specialized nuclear medicine units worldwide.

Manufacturer / TM Owner

Medi-Radiopharma Kft.

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Indications & Clinical Uses

Macrosalb Medi‑Radiopharma, a diagnostic radiopharmaceutical, is used in pulmonary perfusion assessment.

  • Lung perfusion imaging: enables visualization of regional blood flow in the lungs during a ventilation‑perfusion scan.
  • Ventilation‑perfusion (V/Q) scan: provides the perfusion component to evaluate suspected pulmonary embolism.
  • Pre‑operative pulmonary evaluation: assists in assessing lung function before thoracic surgery.

How It Works

  • After intravenous injection, the human albumin macroaggregates, labeled with technetium‑99m, form particles sized 10–90 µm that become temporarily lodged in the pulmonary capillary bed. Their accumulation creates a localized radioactive signal that delineates perfused lung regions, allowing quantitative and qualitative assessment of pulmonary blood flow during imaging.

Side Effects

Macrosalb may be associated with the following adverse reactions.

Common Side Effects

  • Transient dyspnea: short‑lasting shortness of breath after injection.
  • Cough: mild, self‑limiting cough.
  • Chest discomfort: mild pain at the injection site or in the thorax.
  • Mild fever: low‑grade temperature elevation.
  • Headache: transient headache.
  • Nausea: occasional mild nausea.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate medical attention.
  • Pulmonary hypertension: acute rise in pulmonary arterial pressure.
  • Embolic events: rare obstruction of larger pulmonary vessels.
  • Severe hypotension: sudden drop in blood pressure.
  • Acute respiratory distress syndrome (ARDS): rare severe lung inflammation.
  • Cardiac arrhythmia: uncommon rhythm disturbances.

Precautions & Warnings

When using Macrosalb, consider the following precautions.

  • Allergy assessment: verify no known hypersensitivity to human albumin or radiopharmaceutical components.
  • Patient monitoring: observe vital signs and respiratory status during and after administration.
  • Pregnancy and lactation: use only if the diagnostic benefit outweighs potential fetal or infant risk.
  • Concomitant imaging agents: avoid administration within 24 hours of other radiopharmaceuticals that may interfere with imaging interpretation.
  • Cardiopulmonary status: exercise caution in patients with severe pulmonary hypertension or right‑heart failure.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Macrosalb can interact with other substances as follows.

Major Interactions (Avoid)

  • Other radiopharmaceuticals: concurrent use may cause imaging interference and inaccurate results.
  • High‑dose iodine contrast agents: may alter lung perfusion imaging if given within 24 hours.
  • Anticoagulants: may increase the risk of capillary bleeding at the injection site.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may affect pulmonary vascular tone and particle distribution.
  • Vasodilators: could modify capillary trapping of macroaggregates.
  • Drugs affecting albumin binding (e.g., high‑dose albumin infusions): may influence particle behavior.
  • Chemotherapy agents: monitor for additive pulmonary toxicity.
  • Corticosteroids: may mask early allergic reactions.

Frequently Asked Questions

Macrosalb Medi‑Radiopharma is a diagnostic radiopharmaceutical used to assess pulmonary blood flow. It is administered during ventilation‑perfusion (V/Q) scans and other lung perfusion imaging procedures to help detect conditions such as pulmonary embolism, evaluate lung function before surgery, and provide quantitative data on regional lung perfusion.

Human Albumin Macroaggregates are labeled with technetium‑99m and form microscopic particles that, after intravenous injection, become temporarily trapped in the pulmonary capillaries. The trapped particles emit gamma radiation, creating a map of perfused lung areas that can be captured by a gamma camera, allowing clinicians to visualize and quantify lung blood flow.

The dose of Macrosalb Medi‑Radiopharma is determined by the prescribing nuclear medicine physician based on the specific imaging protocol, patient weight, and the required image quality. The prescriber selects the appropriate activity (megabecquerels) to achieve optimal lung perfusion visualization while adhering to radiation safety guidelines.

The pregnancy category for Macrosalb is listed as unknown. Use during pregnancy or lactation should only occur when the diagnostic benefit outweighs any potential risk to the fetus or infant. The prescribing physician should evaluate the clinical necessity and discuss possible alternatives with the patient.

To order Macrosalb Medi‑Radiopharma, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials. The sales team then replies with pricing, availability, shipping details (including cold‑chain if needed) and any required import documentation.

Macrosalb contains human albumin macroaggregates labeled with technetium‑99m, which is the standard agent for lung perfusion imaging. Compared with alternative agents, it offers consistent particle size distribution and reliable capillary trapping, providing high‑quality images. Its safety profile is comparable to other technetium‑99m macroaggregated albumin products, with similar rates of mild adverse reactions.

Macrosalb should be stored at 2‑8 °C in a refrigerator. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking the solution. Maintaining the cold‑chain ensures the radiolabel remains stable and the product retains its intended performance for imaging.

Macrosalb is administered by slow intravenous injection, typically as a bolus through a peripheral vein. The injection is performed by qualified healthcare personnel in a nuclear medicine department, and patients are monitored for a short period after administration to observe any immediate reactions before proceeding with the imaging study.

The most serious risks include severe allergic reactions such as anaphylaxis, acute pulmonary hypertension, and rare embolic events that can obstruct larger pulmonary vessels. These events require immediate medical intervention. Clinicians should be prepared to manage hypersensitivity and monitor patients closely during and after injection.

Macrosalb should be avoided in patients with a known hypersensitivity to human albumin, albumin‑based products, or any component of the radiopharmaceutical. It is also contraindicated in individuals with severe pulmonary hypertension, uncontrolled right‑heart failure, or those who have experienced serious reactions to previous macroaggregated albumin studies.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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