Product image of Macrosalb Medi-Radiopharma (Macrosalb (99mtc)) supplied by GNH India

Macrosalb Medi-Radiopharma

Active Ingredient:
Macrosalb (99mtc)
Origin:
EU

Macrosalb Medi-Radiopharma (Macrosalb (99mtc))

Macrosalb, the active ingredient in Macrosalb Medi‑Radiopharma, is a radiopharmaceutical presented as a kit for radiopharmaceutical preparation for intravenous use. It is used to assess lung perfusion and to aid in the diagnosis of pulmonary embolism in adult patients.

GNH India supplies Macrosalb Medi‑Radiopharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Medi-Radiopharma Kft.

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Indications & Clinical Uses

Macrosalb is employed in nuclear medicine imaging of the pulmonary circulation.

  • Lung perfusion imaging: provides quantitative assessment of regional blood flow in the lungs.
  • Ventilation‑perfusion (V/Q) scan: enables combined evaluation of ventilation and perfusion to detect mismatches.
  • Pulmonary embolism detection: helps identify obstructed pulmonary arteries by revealing perfusion defects.

How It Works

  • Macrosalb contains technetium‑99m labeled macroaggregated albumin particles that, after intravenous injection, become temporarily lodged in the pulmonary capillary bed. The trapped particles emit gamma photons that are captured by a gamma camera, producing images that reflect regional lung perfusion and allow clinicians to evaluate blood flow distribution.

Side Effects

Macrosalb may be associated with adverse reactions related to the radiopharmaceutical preparation and its intravenous administration.

Common Side Effects

  • Injection site pain: mild discomfort at the site of intravenous administration.
  • Transient flushing: brief sensation of warmth or redness.
  • Nausea: mild, short‑lasting nausea.
  • Headache: mild headache occurring shortly after injection.

Serious or Rare Side Effects

  • Allergic reaction: urticaria, bronchospasm, or anaphylaxis.
  • Radiation‑induced tissue injury: rare localized radiation damage.
  • Hemodynamic changes: hypotension or arrhythmia in susceptible patients.

Precautions & Warnings

When using Macrosalb, clinicians should observe specific precautions to ensure patient safety and product integrity.

  • Patient assessment: verify indication and contraindications before administration.
  • Pregnancy status: avoid use unless benefits outweigh potential fetal radiation exposure.
  • Thyroid protection: consider thyroid blockade in patients at risk of iodine uptake.
  • Renal function: assess kidney function as radiopharmaceutical clearance may be affected.
  • Allergies: inquire about known hypersensitivity to albumin or technetium compounds.
  • Store at ambient temperature: keep kit below 25°C, protect from moisture and light, and use before expiry.

Avoid Interactions

Macrosalb may interact with certain agents that affect radiation distribution or physiological responses.

Major Interactions (Avoid)

  • Iodine‑containing contrast agents: can interfere with technetium imaging and increase radiation exposure.
  • Thyroid‑blocking agents (e.g., potassium iodide) administered shortly before: may alter biodistribution.

Moderate Interactions (Monitor Closely)

  • Vasodilators: may influence pulmonary blood flow and affect imaging interpretation.
  • Beta‑blockers: could modify heart rate, impacting image acquisition timing.
  • Antihistamines: may mask early signs of allergic reactions.

Frequently Asked Questions

Macrosalb is a radiopharmaceutical used in nuclear medicine to image lung perfusion. It is commonly employed in ventilation‑perfusion (V/Q) scans and to help diagnose pulmonary embolism by highlighting areas of reduced blood flow within the lungs.

Macrosalb contains technetium‑99m labeled macroaggregated albumin particles. After intravenous injection, the particles become temporarily trapped in the pulmonary capillaries, emitting gamma radiation that a gamma camera detects, producing a visual map of regional lung blood flow.

The administered activity of Macrosalb is determined by the prescribing physician or nuclear medicine specialist based on the specific imaging protocol, patient size, and regulatory guidelines. The exact dose is not standardized and must be individualized.

Safety data for Macrosalb in pregnancy and lactation are limited. It should be avoided unless the diagnostic benefit outweighs potential fetal or infant radiation exposure. Clinicians should discuss risks with the patient and consider alternative imaging methods when possible.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Macrosalb (technetium‑99m macroaggregated albumin) is the most widely used perfusion agent because of its favorable particle size, rapid lung uptake, and short half‑life. Alternatives such as xenon gas or other radiolabeled particles exist, but they may require special equipment, have different imaging characteristics, or provide less consistent capillary lodging.

Macrosalb kits should be stored at ambient temperature, preferably below 25 °C, protected from moisture and light. Keep the kit in its original sealed container until preparation, and use it before the expiration date indicated on the label.

Macrosalb is prepared according to the kit instructions and administered intravenously by a qualified healthcare professional. The injection is typically performed as a rapid bolus, followed by immediate imaging with a gamma camera to capture lung perfusion data.

The most serious risks include severe allergic reactions such as anaphylaxis, rare radiation‑induced tissue injury, and hemodynamic disturbances like hypotension or arrhythmias, particularly in patients with underlying cardiovascular disease.

Macrosalb should not be administered to patients with known hypersensitivity to albumin, technetium‑99m, or any kit components. It is also contraindicated in pregnant women unless the diagnostic benefit justifies the potential fetal radiation exposure, and in patients with severe uncontrolled cardiopulmonary conditions where perfusion imaging may be unsafe.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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