Macrovic Junior (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Macrovic Junior is used as an osmotic laxative and electrolyte solution for pediatric gastrointestinal care.

• Constipation: helps soften stool and promote regular bowel movements in children.
• Bowel preparation for colonoscopy: clears the intestinal tract before diagnostic or therapeutic procedures.
• Acute diarrhoea with electrolyte loss: provides sodium, potassium and chloride to replace losses and maintain fluid balance.

• Macrogol 3350 creates an osmotic gradient that retains water in the intestinal lumen, increasing stool volume and softness. The accompanying electrolytes (sodium, potassium, chloride) maintain osmolar balance and prevent dehydration, while sodium hydrogen carbonate acts as a buffering agent to stabilize intestinal pH. Together these actions facilitate bowel evacuation without significant fluid shifts.

Macrovic Junior may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Abdominal bloating: feeling of fullness or swelling in the abdomen.
• Nausea: mild to moderate sensation of wanting to vomit.
• Flatulence: increased intestinal gas.
• Diarrhoea: loose, watery stools.
• Abdominal pain: cramping or discomfort.
• Headache: mild to moderate head pain.

Serious or Rare Side Effects

• Severe electrolyte imbalance: abnormal sodium or potassium levels requiring medical attention.
• Allergic reaction: rash, itching, swelling, or difficulty breathing.
• Dehydration: excessive fluid loss leading to dizziness or low blood pressure.

Before using Macrovic Junior, consider the following safety measures.

• Intestinal obstruction: avoid use if there is known blockage or perforation.
• Renal impairment: monitor kidney function and electrolyte status.
• Hypersensitivity: discontinue if allergic reactions occur.
• Concomitant laxatives: avoid combining with other osmotic agents without medical advice.
• Pediatric dosing: follow prescriber instructions precisely for age and weight.
• Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Macrovic Junior can interact with other medications that affect fluid and electrolyte balance.

Major Interactions (Avoid)

• Loop diuretics: may exacerbate electrolyte loss.
• Sodium‑containing IV fluids: risk of hypernatremia.
• Other osmotic laxatives: increase risk of severe diarrhoea.

Moderate Interactions (Monitor Closely)

• NSAIDs: may increase gastrointestinal irritation.
• Antacids containing sodium: could alter electrolyte composition.
• Antihypertensives: monitor blood pressure if significant fluid shifts occur.