Product image of Macrovic (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350) supplied by GNH India

Macrovic

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350
Origin:
EU

Macrovic (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Macrogol 3350, the active ingredient in Macrovic, is an osmotic laxative presented as a powder for oral use. Combined with sodium hydrogen carbonate, potassium chloride and sodium chloride, it provides electrolyte balance while promoting bowel evacuation for constipation and colonoscopy preparation.
GNH India supplies Macrovic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Strides Nordic Aps

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Indications & Clinical Uses

Macrovic is employed to manage conditions that require bowel clearance and electrolyte support.

  • Constipation: softens stool and promotes regular bowel movements through osmotic water retention.
  • Colonoscopy preparation: achieves thorough colonic cleansing by inducing evacuation of fecal material before endoscopic procedures.
  • Electrolyte replacement: supplies sodium, potassium and chloride to help correct mild electrolyte disturbances associated with bowel cleansing.

How It Works

  • Macrogol 3350 creates an osmotic gradient that retains water in the intestinal lumen, increasing stool volume and softness. The accompanying electrolytes (sodium hydrogen carbonate, potassium chloride, sodium chloride) maintain isotonicity, preventing excessive fluid shifts and supporting normal electrolyte balance during bowel evacuation.

Side Effects

Macrovic may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Bloating: sensation of abdominal fullness.
  • Abdominal discomfort: mild cramps or pain.
  • Nausea: feeling of sickness.
  • Flatulence: increased gas production.
  • Diarrhea: loose stools.
  • Mild electrolyte imbalance: slight changes in sodium or potassium levels.

Serious or Rare Side Effects

  • Severe dehydration: significant fluid loss requiring medical attention.
  • Marked electrolyte disturbances: hypernatremia, hyperkalemia, or hyponatremia.
  • Allergic reactions: rash, itching, or swelling.
  • Severe abdominal pain: persistent or worsening pain.
  • Intestinal perforation: rare but life‑threatening.
  • Anaphylaxis: acute, systemic allergic response.

Precautions & Warnings

Before prescribing Macrovic, clinicians should consider several safety measures.

  • Assess renal function: adjust use in patients with severe renal impairment due to electrolyte load.
  • Monitor electrolytes: check serum sodium and potassium during prolonged therapy.
  • Avoid in bowel obstruction: contraindicated in mechanical obstruction.
  • Use caution in elderly: increased risk of dehydration and electrolyte shifts.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Store at ambient temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Macrovic can interact with several medication classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Loop diuretics: may exacerbate electrolyte loss.
  • Lithium: increased risk of lithium toxicity due to sodium changes.
  • ACE inhibitors/ARBs: potential for hyperkalemia.
  • Antacids containing sodium bicarbonate: additive sodium load.
  • Other osmotic laxatives: risk of excessive fluid loss.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may affect renal function, influencing electrolyte handling.
  • Corticosteroids: may increase risk of fluid/electrolyte imbalance.
  • Anticholinergic agents: may reduce efficacy of bowel cleansing.

Frequently Asked Questions

Macrovic is an oral powder that combines macrogol 3350 with electrolytes to treat constipation, prepare the bowel for colonoscopy, and provide mild electrolyte replacement during bowel cleansing procedures.

Macrogol 3350 is an osmotic agent that draws water into the intestinal lumen, increasing stool volume and softness. This promotes bowel movements while the added electrolytes help maintain fluid balance.

The dose of Macrovic is individualized by the prescribing clinician based on the indication, patient age, weight, and renal function. Patients should follow the specific instructions provided by their healthcare professional.

Safety in pregnancy and lactation has not been fully established. Healthcare professionals should evaluate the risk‑benefit profile before prescribing Macrovic to pregnant or nursing individuals.

To order Macrovic, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Macrovic combines an osmotic laxative (macrogol 3350) with balanced electrolytes, offering effective bowel cleansing with reduced risk of severe electrolyte disturbance compared with some sodium‑based preparations. It is generally well tolerated and suitable for patients needing both cleansing and electrolyte support.

Store Macrovic at ambient temperature, preferably below 25 °C. Keep the powder in its original packaging, protect it from moisture and direct heat, and ensure the container is tightly closed to maintain product stability.

Macrovic is taken orally. The powder is typically dissolved in a specified volume of water according to the prescriber’s instructions and consumed in divided doses as directed for the intended indication.

Serious risks include severe dehydration, marked electrolyte disturbances such as hypernatremia or hyperkalemia, allergic reactions, and, rarely, intestinal perforation. Patients should seek immediate medical attention if they experience extreme weakness, persistent vomiting, severe abdominal pain, or signs of an allergic reaction.

Macrovic should be avoided in individuals with known mechanical bowel obstruction, severe renal impairment, uncontrolled electrolyte disorders, or hypersensitivity to any of its components. Clinicians should also exercise caution in patients on interacting medications such as loop diuretics or lithium.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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