Product image of Macrovic (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350) supplied by GNH India

Macrovic

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350
Origin:
EU

Macrovic (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Macrovic, the active ingredient in Macrovic, is an electrolyte solution / osmotic laxative presented as an oral solution for oral use. It helps correct fluid loss, electrolyte imbalance and constipation. GNH India supplies Macrovic as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Strides Pharma (Cyprus) Limited

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Indications & Clinical Uses

Macrovic is used in the management of fluid and electrolyte disorders and constipation.

  • Dehydration due to fluid loss: restores fluid balance and replaces lost electrolytes.
  • Electrolyte replacement: supplies sodium, potassium, chloride and bicarbonate to correct electrolyte imbalances.
  • Constipation: softens stools by retaining water in the intestinal lumen, facilitating bowel movements.
  • Bowel preparation: provides an osmotic effect to cleanse the colon prior to diagnostic procedures.

How It Works

  • Macrovic supplies sodium, potassium, chloride and bicarbonate ions, directly replenishing extracellular electrolyte pools. The macrogol 3350 component remains in the intestinal lumen, creating an osmotic gradient that draws water into the bowel, softening stool and promoting peristalsis, while the electrolytes aid in maintaining acid‑base balance and cellular function.

Side Effects

Macrovic may be associated with a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Abdominal bloating: feeling of fullness or distension in the abdomen.
  • Nausea: mild to moderate sensation of wanting to vomit.
  • Diarrhea: loose or watery stools.
  • Flatulence: increased intestinal gas.

Serious or Rare Side Effects

  • Severe dehydration: excessive fluid loss leading to hypotension.
  • Electrolyte disturbances: significant hypernatremia or hyperkalemia.
  • Allergic reaction: rash, itching, swelling, or difficulty breathing.

Precautions & Warnings

When prescribing Macrovic, consider the following precautions.

  • Assess hydration status: evaluate fluid loss before initiating therapy.
  • Monitor electrolytes: check serum sodium, potassium, chloride and bicarbonate levels regularly.
  • Use with caution in renal impairment: adjust volume to avoid overload.
  • Avoid in patients with intestinal obstruction: risk of worsening blockage.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Macrovic can interact with other medications that affect fluid and electrolyte balance.

Major Interactions (Avoid)

  • Concomitant use with other osmotic laxatives: may cause severe electrolyte loss.
  • High-dose potassium supplements: risk of hyperkalemia.

Moderate Interactions (Monitor Closely)

  • Diuretics: may amplify fluid and electrolyte shifts.
  • Antihypertensive agents: potential for additive blood pressure reduction due to volume changes.
  • NSAIDs: can affect renal function, altering electrolyte handling.

Frequently Asked Questions

Macrovic is an oral electrolyte solution and osmotic laxative used to treat dehydration caused by fluid loss, replace essential electrolytes such as sodium, potassium, chloride and bicarbonate, and to relieve constipation by softening stools. It is also employed as a bowel‑preparation agent before certain diagnostic procedures.

The formulation provides sodium, potassium, chloride and bicarbonate ions that directly replenish depleted electrolyte stores. Macrogol 3350 remains in the intestinal lumen, creating an osmotic gradient that draws water into the bowel, which softens stool and promotes regular bowel movements while supporting acid‑base balance.

The dose of Macrovic is individualized. A qualified prescriber determines the appropriate volume based on the patient’s degree of dehydration, electrolyte status, age, weight and clinical condition. The prescribing information provides guidance, but the exact regimen should be set by a healthcare professional.

Safety data for Macrovic in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Healthcare providers should evaluate the clinical situation and discuss potential risks with the patient before prescribing.

To request Macrovic, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Macrovic combines a full electrolyte profile (sodium, potassium, chloride, bicarbonate) with macrogol 3350, an osmotic agent. Compared with standard oral rehydration salts that lack a laxative component, Macrovic also addresses constipation. The choice depends on whether simultaneous bowel cleansing is desired alongside rehydration.

Macrovic should be stored at ambient temperature, preferably below 25 °C. Keep the container tightly closed, protect it from moisture and direct sunlight, and avoid freezing. Follow any additional handling instructions on the label to maintain product stability.

Macrovic is taken orally as a liquid solution. The prescribed volume is measured using the provided dosing device or a calibrated syringe and consumed directly or mixed with a small amount of water, as directed by the prescriber. It should be taken with or without food according to clinical guidance.

Serious risks include severe dehydration if excessive fluid loss occurs, significant electrolyte disturbances such as hypernatremia or hyperkalemia, and allergic reactions that may present as rash, swelling or breathing difficulty. Patients should be monitored for these events, especially when large volumes are administered.

Macrovic is contraindicated in individuals with known hypersensitivity to any of its components, those with complete intestinal obstruction, and patients in whom fluid overload could be hazardous, such as certain cases of severe heart or renal failure. Clinicians must assess each patient’s condition before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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