Product image of Madecassol (Centella Asiatica Extract) supplied by GNH India

Madecassol

Active Ingredient:
Centella Asiatica Extract
Origin:
EU

Madecassol (Centella Asiatica Extract)

Centella asiatica extract, the active ingredient in Madecassol, is a herbal topical presented as a cutaneous preparation for external use. It promotes wound healing and skin regeneration, helping to restore the integrity of damaged tissue in adult patients, including minor burns, abrasions and postoperative incisions.

GNH India supplies Madecassol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution, with full traceability and batch release testing.

Manufacturer / TM Owner

Bayer Healthcare

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Indications & Clinical Uses

Madecassol is a herbal topical that acts on the skin’s wound‑healing processes.

  • Minor burns: accelerates re‑epithelialisation and reduces inflammation.
  • Surgical incisions: supports scar minimisation and tissue repair.
  • Chronic ulcers: aids granulation tissue formation and promotes wound closure.

How It Works

  • Centella asiatica extract enhances fibroblast proliferation and collagen synthesis while modulating inflammatory mediators. The phytochemicals stimulate the TGF‑β pathway and increase extracellular matrix production, leading to accelerated tissue repair and reduced scar formation at the site of application.

Side Effects

Adverse reactions are generally mild and limited to the application site.

Common Side Effects

  • Mild skin irritation: transient redness or tingling at the site.
  • Transient erythema: temporary redness that resolves without treatment.
  • Pruritus: mild itching that subsides with continued use.

Serious or Rare Side Effects

  • Allergic contact dermatitis: severe rash, swelling, or blistering requiring medical attention.
  • Severe hypersensitivity reaction: systemic symptoms such as urticaria or angioedema.
  • Infection at application site: secondary bacterial infection requiring antibiotics.

Precautions & Warnings

Use Madecassol with awareness of specific safety considerations.

  • Pregnancy: safety not established; avoid unless clearly needed.
  • Breastfeeding: caution advised; limited data on infant exposure.
  • Skin integrity: do not apply on infected, necrotic, or heavily exudative wounds.
  • Concurrent topical agents: monitor for additive irritation when used with other creams or ointments.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Madecassol may interact with other topical or systemic agents.

Major Interactions (Avoid)

  • Concurrent use with potent corticosteroid creams: may diminish the herbal product’s efficacy.
  • Use with photosensitizing agents: increased risk of phototoxic reactions on sun‑exposed skin.

Moderate Interactions (Monitor Closely)

  • Combination with other herbal extracts: potential additive skin irritation.
  • Concurrent systemic anti‑inflammatory drugs: monitor wound‑healing progress for any delay.
  • Use with occlusive dressings: may increase percutaneous absorption and irritation.

Frequently Asked Questions

Madecassol is a herbal topical preparation containing Centella asiatica extract. It is used to support the healing of minor burns, abrasions, surgical incisions and chronic skin ulcers by promoting tissue regeneration and reducing inflammation.

Centella asiatica extract stimulates fibroblast activity and collagen production while modulating inflammatory pathways. The resulting effect accelerates re‑epithelialisation, improves granulation tissue formation and helps minimise scar tissue during the wound‑healing process.

The specific amount and frequency of Madecassol application are determined by the prescribing healthcare professional based on the wound type, size and patient condition. No fixed dosing regimen is provided in public documentation.

Safety data for Madecassol in pregnancy and lactation are limited. It is generally advised to avoid use unless the potential benefit outweighs the unknown risk, and to discuss any intended use with a qualified medical practitioner.

To place an order, submit an enquiry on the Madecassol product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Madecassol’s active ingredient, Centella asiatica extract, offers a natural mechanism that enhances collagen synthesis and fibroblast proliferation, which differs from synthetic agents such as silver sulfadiazine or antibiotic ointments. It is generally well tolerated and may be preferred when a non‑antibiotic, plant‑based option is desired.

Store Madecassol at room temperature, ideally below 25 °C. Keep the container tightly closed, protect it from direct sunlight, moisture and extreme temperatures to maintain product stability and potency.

Madecassol is applied topically to clean, dry skin. A thin layer is spread over the affected area using clean hands or a sterile applicator, and the site is then covered with a non‑occlusive dressing if required. Follow the prescriber’s instructions regarding frequency and duration.

The most serious risks include allergic contact dermatitis, severe hypersensitivity reactions such as urticaria or angioedema, and secondary infection of the treated area. Patients should discontinue use and seek medical attention if any signs of a serious reaction develop.

Madecassol should not be used on patients with known hypersensitivity to Centella asiatica or any excipients in the formulation, on open or infected wounds without medical supervision, and on individuals where safety during pregnancy or lactation cannot be assured.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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