Product image of Madonella Mite (Ethinylestradiol, Levonorgestrel) supplied by GNH India

Madonella Mite

Active Ingredient:
Ethinylestradiol, Levonorgestrel
Origin:
EU

Madonella Mite (Ethinylestradiol, Levonorgestrel)

Ethinylestradiol and Levonorgestrel, the active ingredients in Madonella Mite, are a combined estrogen‑progestogen oral contraceptive presented as a tablet for oral use. It prevents pregnancy by inhibiting ovulation and altering cervical mucus in women of reproductive age.

GNH India supplies Madonella Mite as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides reliable global distribution through established logistics networks.

Manufacturer / TM Owner

Kwizda Pharma Gmbh

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Indications & Clinical Uses

  • Madonella Mite, a combined estrogen‑progestogen oral contraceptive, is indicated for the following clinical uses:
  • Contraception: Prevents pregnancy in women of childbearing potential.
  • Menstrual cycle regulation: Provides regular cycles and reduces dysmenorrhea.
  • Acne treatment: Improves moderate acne linked to hormonal fluctuations.
  • Premenstrual syndrome relief: Alleviates PMS symptoms such as bloating and mood swings.
  • Endometriosis management: Reduces pain associated with endometriosis.

How It Works

  • Ethinylestradiol and levonorgestrel bind to estrogen and progesterone receptors, respectively, suppressing the mid‑cycle surge of luteinizing hormone (LH) and follicle‑stimulating hormone (FSH). This inhibition prevents ovulation, while the progestogenic component thickens cervical mucus and induces endometrial changes that hinder fertilization and implantation.

Side Effects

Madonella Mite may cause a range of adverse reactions, which are grouped by frequency.

Common Side Effects

  • Nausea
  • Headache
  • Breast tenderness
  • Spotting or breakthrough bleeding
  • Weight gain
  • Mood changes

Serious or Rare Side Effects

  • Deep vein thrombosis
  • Pulmonary embolism
  • Stroke
  • Myocardial infarction
  • Severe hypertension
  • Hepatic adenoma or other liver tumors

Precautions & Warnings

  • Before prescribing Madonella Mite, clinicians should consider the following precautions:
  • Avoid use in pregnancy: product is contraindicated (Category X).
  • Avoid use in active or past thromboembolic disease: increased clot risk.
  • Avoid smoking in women over 35 years: heightened cardiovascular risk.
  • Monitor blood pressure regularly: oral contraceptives may elevate BP.
  • Assess liver function: contraindicated in severe hepatic impairment.
  • Store at ambient temperature: keep below 25°C, protect from moisture and light.

Avoid Interactions

Madonella Mite can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Enzyme‑inducing anticonvulsants (e.g., carbamazepine, phenytoin): reduced contraceptive effect.
  • Rifampin or rifabutin: decreased hormone levels, risk of pregnancy.
  • Protease inhibitors (e.g., ritonavir): may lower effectiveness.

Moderate Interactions (Monitor Closely)

  • St. John’s wort: may diminish contraceptive efficacy.
  • Certain antihypertensives: oral contraceptives can reduce BP control.
  • Selective serotonin reuptake inhibitors: may increase mood‑related side effects.

Frequently Asked Questions

Madonella Mite is a combined estrogen‑progestogen oral contraceptive used to prevent pregnancy in women of reproductive age. It is also prescribed to regulate menstrual cycles, treat moderate hormonal acne, relieve premenstrual syndrome symptoms, and manage endometriosis‑related pain.

Ethinylestradiol and levonorgestrel act on estrogen and progesterone receptors, respectively. Together they suppress the mid‑cycle surge of luteinizing hormone (LH) and follicle‑stimulating hormone (FSH), preventing ovulation. The progestogen also thickens cervical mucus and alters the endometrial lining, creating conditions that hinder fertilization and implantation.

The dosing regimen for Madonella Mite is determined by the prescribing healthcare professional. Typically, the product is taken as one tablet daily at the same time each day, but the exact schedule and duration should follow the prescriber’s instructions and the product’s labeling.

Madonella Mite is contraindicated in pregnancy (Category X) and must not be started or continued by a woman who is pregnant. While limited data exist for breastfeeding, combined oral contraceptives are generally not recommended during lactation without medical guidance, as they may affect milk production.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Madonella Mite. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Madonella Mite contains the standard dose combination of ethinylestradiol and levonorgestrel, which is comparable to many other combined oral contraceptives on the market. Its efficacy, safety profile, and side‑effect spectrum are similar to alternative products, though individual tolerability may vary based on patient‑specific factors such as hormone sensitivity or comorbid conditions.

Store Madonella Mite tablets at ambient temperature, preferably below 25 °C. Keep the container tightly closed, protect it from moisture, light and excessive heat, and retain the original packaging until use to maintain product stability.

Madonella Mite is taken orally. The tablet should be swallowed whole with water, preferably at the same time each day. No food restrictions are required, but consistent timing helps maintain steady hormone levels and maximizes contraceptive effectiveness.

Serious risks include venous thromboembolism, pulmonary embolism, stroke, myocardial infarction, severe hypertension, and rare liver tumors. These events are more likely in women with pre‑existing clotting disorders, smokers over 35, or those with uncontrolled hypertension, and require immediate medical attention if symptoms arise.

Madonella Mite should not be used by women who are pregnant, have a history of thromboembolic disease, uncontrolled hypertension, severe liver disease, known or suspected breast cancer, or who are over 35 and smoke heavily. It is also contraindicated in individuals with known hypersensitivity to either ethinylestradiol or levonorgestrel.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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