Product image of Madopar (Benserazide Hydrochloride, Levodopa) supplied by GNH India

Madopar

Active Ingredient:
Benserazide Hydrochloride, Levodopa
Origin:
EU

Madopar (Benserazide Hydrochloride, Levodopa)

Levodopa/Benserazide, the active ingredients in Madopar, are an antiparkinson agent presented as an oral tablet for oral use. They act as a dopamine precursor combined with a peripheral decarboxylase inhibitor to manage Parkinson's disease and Parkinsonian syndromes in adult patients.

GNH India supplies Madopar as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for regulated markets. Its distribution network ensures timely delivery and compliance with local regulatory requirements.

Manufacturer / TM Owner

Roche Eesti Oü

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Indications & Clinical Uses

Madopar is used in the management of Parkinsonian disorders, targeting dopaminergic deficiency in the central nervous system.

  • Parkinson's disease: improves motor symptoms such as bradykinesia, rigidity and tremor.
  • Parkinsonian syndrome: alleviates motor dysfunction associated with secondary Parkinsonism.
  • Early-stage Parkinson's disease: provides symptomatic relief to delay functional decline.
  • Motor fluctuations in advanced Parkinson's disease: reduces OFF periods and improves ON time.
  • Dyskinesia management: used with other agents to balance motor complications.

How It Works

  • Madopar combines levodopa, a dopamine precursor that crosses the blood‑brain barrier, with benserazide, a peripheral dopa‑decarboxylase inhibitor. Benserazide blocks conversion of levodopa to dopamine outside the CNS, increasing central availability and reducing peripheral side effects. The elevated brain dopamine restores dopaminergic neurotransmission, mitigating the motor deficits characteristic of Parkinsonian disorders.

Side Effects

Madopar may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Orthostatic hypotension: dizziness upon standing.
  • Dyskinesia: involuntary movements, especially at higher doses.
  • Insomnia: difficulty sleeping.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: life‑threatening reaction with fever and rigidity.
  • Severe psychiatric disturbances: hallucinations or psychosis.
  • Cardiac arrhythmias: irregular heart rhythm requiring medical attention.

Precautions & Warnings

When prescribing Madopar, clinicians should consider several precautionary measures to ensure safe use.

  • Renal impairment: adjust dose as benserazide is renally excreted.
  • Hepatic disease: monitor liver function due to levodopa metabolism.
  • Cardiovascular disease: use caution in patients with arrhythmias or ischemic heart disease.
  • Psychiatric history: observe for emergence of hallucinations or psychosis.
  • Pregnancy and lactation: avoid use unless benefits outweigh potential risks.
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture.

Avoid Interactions

Madopar can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Antipsychotics (e.g., haloperidol): may diminish antiparkinson effect.

Moderate Interactions (Monitor Closely)

  • COMT inhibitors (e.g., entacapone): increase levodopa levels, may require dose adjustment.
  • Iron supplements: reduce levodopa absorption; separate administration by at least 2 hours.
  • Antihypertensives: additive effect on blood pressure, monitor for hypotension.

Frequently Asked Questions

Madopar is prescribed to manage the motor symptoms of Parkinson's disease and related Parkinsonian syndromes. By increasing dopamine levels in the brain, it helps reduce tremor, rigidity, bradykinesia, and improves overall motor function in adult patients.

Levodopa serves as a precursor that crosses the blood‑brain barrier and is converted to dopamine within the central nervous system. Benserazide inhibits the peripheral enzyme dopa‑decarboxylase, preventing premature conversion of levodopa outside the brain, thereby enhancing central dopamine availability.

The appropriate dose of Madopar is individualized and determined by the prescribing clinician based on disease severity, patient response, and tolerability. Dosage adjustments are made during treatment to achieve optimal symptom control while minimizing side effects.

The safety of Madopar during pregnancy and lactation has not been definitively established. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To order Madopar, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

The most common alternative is Sinemet, which combines levodopa with carbidopa. Both formulations aim to increase central dopamine, but benserazide in Madopar offers a similar peripheral decarboxylase inhibition to carbidopa. Clinical efficacy and safety profiles are comparable, with choice often based on regional availability or patient tolerance.

Madopar tablets should be stored at ambient temperature, below 25 °C, in the original container to protect from moisture. Keep the product out of direct sunlight and out of reach of children. Do not use if the packaging is damaged.

Madopar is taken orally, usually with a full glass of water. It can be taken with or without food, but high‑protein meals may interfere with levodopa absorption, so spacing the dose from protein‑rich meals is often recommended.

Serious risks include neuroleptic malignant syndrome, severe psychiatric reactions such as hallucinations or psychosis, and cardiac arrhythmias. Patients should seek immediate medical attention if they experience high fever, muscle rigidity, sudden confusion, or irregular heartbeats.

Madopar is contraindicated in individuals with known hypersensitivity to levodopa or benserazide, those taking non‑selective MAO inhibitors, patients with narrow‑angle glaucoma, and individuals with severe cardiovascular disease where dopamine fluctuations could be hazardous.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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