Product image of Madopark Quick (Benserazide Hydrochloride, Levodopa) supplied by GNH India

Madopark Quick

Active Ingredient:
Benserazide Hydrochloride, Levodopa
Origin:
EU

Madopark Quick (Benserazide Hydrochloride, Levodopa)

Levodopa / Benserazide, the active ingredient in Madopark Quick, is a dopamine precursor with dopa decarboxylase inhibitor presented as an immediate‑release oral tablet for oral use. It treats Parkinson's disease in adults.

GNH India supplies Madopark Quick as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Roche Ab

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Indications & Clinical Uses

Madopark Quick is indicated for the management of Parkinsonian disorders by restoring central dopamine levels.

  • Parkinson's disease: Improves motor symptoms and functional ability in patients with idiopathic Parkinson's disease.
  • Motor fluctuations in Parkinson's disease: Reduces OFF periods and increases ON time without troublesome dyskinesia.
  • Drug‑induced parkinsonism: Provides symptomatic relief when anticholinergic therapy is insufficient.

How It Works

  • Levodopa crosses the blood‑brain barrier and is enzymatically converted to dopamine, replenishing deficient central stores. Benserazide, a peripheral aromatic L‑amino acid decarboxylase inhibitor, blocks peripheral conversion of levodopa, enhancing its cerebral availability and minimizing peripheral side effects such as nausea.

Side Effects

Common Side Effects

  • Nausea: Upset stomach or feeling sick.
  • Orthostatic hypotension: Dizziness upon standing.
  • Headache: Mild to moderate head pain.
  • Insomnia: Difficulty falling or staying asleep.
  • Dyskinesia: Involuntary movements, especially at higher doses.
  • Dry mouth: Reduced salivation.

Serious or Rare Side Effects

  • Severe hypotension: Marked drop in blood pressure requiring medical attention.
  • Psychosis or hallucinations: Visual or auditory disturbances.
  • Neuroleptic malignant syndrome: Rare but life‑threatening reaction.
  • Cardiac arrhythmias: Irregular heart rhythms.
  • Severe allergic reactions: Rash, swelling, or breathing difficulty.

Precautions & Warnings

When prescribing Madopark Quick, clinicians should consider several safety measures.

  • Dose titration: Start with a low dose and increase gradually to minimize side effects.
  • Blood pressure monitoring: Watch for orthostatic hypotension, especially in the elderly.
  • Psychiatric assessment: Monitor for hallucinations, confusion, or mood changes.
  • Contraindications: Avoid in patients with narrow‑angle glaucoma or those taking non‑selective MAO inhibitors.
  • Renal/hepatic impairment: Adjust dosing based on organ function.
  • Store at ambient temperature: Keep in the original pack, protect from moisture.

Avoid Interactions

Madopark Quick may interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: Risk of hypertensive crisis.
  • Antipsychotics (dopamine antagonists): Reduce therapeutic effect.
  • High‑dose pyridoxine (vitamin B6): Decreases levodopa availability.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: May enhance blood‑pressure‑lowering effect.
  • SSRIs or other serotonergic drugs: Potential for serotonin syndrome.
  • Other dopaminergic agents: May increase risk of dyskinesia.

Frequently Asked Questions

Madopark Quick is prescribed to manage the motor symptoms of Parkinson's disease. It helps improve tremor, rigidity, bradykinesia, and overall functional ability by increasing dopamine levels in the brain.

Levodopa is a dopamine precursor that crosses the blood‑brain barrier and is converted into dopamine. Benserazide inhibits peripheral decarboxylation of levodopa, allowing more of the drug to reach the brain and reducing peripheral side effects such as nausea.

The dose of Madopark Quick is individualized. A qualified prescriber determines the appropriate starting dose and titration schedule based on the patient’s clinical condition, age, and response to therapy.

Safety data in pregnancy and lactation are limited. The medication should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and only under medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Madopark Quick combines levodopa with benserazide, similar to the levodopa/carbidopa combination used in other brands. Both formulations increase central dopamine while limiting peripheral conversion, but benserazide may have a slightly different pharmacokinetic profile, offering comparable efficacy and safety.

Store the tablets at ambient temperature, below 25 °C, in the original container. Protect them from moisture and direct sunlight to maintain potency throughout the shelf life.

Madopark Quick is taken orally with a glass of water. It can be taken with or without food, but a consistent routine helps maintain stable plasma levels. Swallow the tablet whole; do not crush or chew.

Serious risks include severe hypotension, neuroleptic malignant syndrome, cardiac arrhythmias, and psychiatric disturbances such as hallucinations or psychosis. Patients should be monitored closely for these events, especially during dose adjustments.

Individuals with known hypersensitivity to levodopa or benserazide, patients with narrow‑angle glaucoma, and those currently taking non‑selective MAO inhibitors should avoid Madopark Quick. Contra‑indications are confirmed by the prescribing clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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