Magaldrato Mylan (Magaldrate)

Magaldrate is an antacid used to manage conditions associated with excess gastric acidity.

• Heartburn: provides rapid relief of burning sensation by neutralizing stomach acid.
• Acid indigestion: reduces discomfort and bloating caused by excess acidity.
• Gastric ulcer: promotes healing by maintaining a higher gastric pH environment.
• Duodenal ulcer: helps protect the duodenal lining and supports ulcer resolution.

• Magaldrate acts as a dual‑salt antacid. When it contacts gastric hydrochloric acid, the magnesium and aluminum components react to form magnesium chloride, aluminum hydroxide and water, thereby consuming hydrogen ions and raising the pH of gastric contents. This neutralization reduces acidity and alleviates irritation of the mucosa. The resulting alkaline environment also limits the activity of pepsin, further protecting the gastric lining.

Magaldrate may cause adverse reactions, most of which are mild and transient.

Common Side Effects

• Constipation: mild difficulty passing stool that usually resolves with continued use.
• Diarrhea: loose stools, generally temporary and self‑limiting.
• Nausea: feeling of sickness that may subside after the first dose.
• Flatulence: increased gas production causing abdominal bloating.
• Metallic taste: transient metallic sensation in the mouth without lasting effect.
• Abdominal discomfort: mild cramps or pain in the stomach area.

Serious or Rare Side Effects

• Hypermagnesemia: elevated magnesium levels, particularly in patients with renal impairment, which may cause muscle weakness or cardiac effects.
• Severe allergic reaction: rash, itching, swelling, or breathing difficulty that requires immediate medical attention.

When using Magaldrate, certain precautions should be observed to ensure safety and effectiveness.

• Renal impairment: use with caution and monitor magnesium levels.
• Gastrointestinal obstruction: avoid if there is known blockage or severe constipation.
• Drug absorption: antacids may reduce absorption of certain antibiotics and iron supplements; separate dosing by at least 2 hours.
• Pregnancy and lactation: consult a healthcare professional before use.
• Elderly patients: monitor for electrolyte disturbances due to altered renal function.
• Store at ambient temperature: keep below 25°C in the original packaging, protected from moisture and direct sunlight.

Magaldrate can interact with other medicines, altering their effectiveness or increasing the risk of adverse effects.

Major Interactions (Avoid)

• Tetracycline antibiotics: reduced absorption leading to therapeutic failure.
• Fluoroquinolones (e.g., ciprofloxacin): decreased bioavailability and possible resistance.

Moderate Interactions (Monitor Closely)

• Iron supplements: antacid may lower iron absorption; separate doses.
• Levothyroxine: may impair hormone uptake; monitor thyroid function.
• Digoxin: increased serum levels possible; check cardiac status.